Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability?
Hahnefeld, L.; Gurke, R.; Thomas, D.; Schreiber, Y.; Schäfer, S.M.G.; Trautmann, S.; Snodgrass, I.F.; Kratz, D.; Geisslinger, G.; Ferreiros, N.
Journal Article
2020The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP)
Schäfer, S.M.G.; Sendetski, M.; Angioni, C.; Nüsing, R.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
20194 Ds in health research - working together toward rapid precision medicine
Niederberger, E.; Parnham, M.J.; Maas, J.; Geisslinger, G.
Journal Article
20195-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift
Martin, L.M.; Möller, M.; Weiss, U.; Russe, O.Q.; Scholich, K.; Pierre, S.; Geisslinger, G.; Niederberger, E.
Journal Article
2019Cancer-induced inflammation and inflammation-induced cancer in colon: A role for S1P lyase
Schwiebs, A.; Herrero San Juan, M.; Schmidt, K.G.; Wiercinska, E.; Anlauf, M.; Ottenlinger, F.; Thomas, D.; Elwakeel, E.; Weigert, A.; Farin, H.F.; Bonig, H.; Scholich, K.; Geisslinger, G.; Pfeilschifter, J.M.; Radeke, H.H.
Journal Article
2019Ceramides as Novel Disease Biomarkers
Kurz, J.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
Journal Article
2019Computer-Aided Selective Optimization of Side Activities of Talinolol
Hiesinger, K.; Kramer, J.S.; Achenbach, J.; Moser, D.; Weber, J.; Wittmann, S.K.; Morisseau, C.; Angioni, C.; Geisslinger, G.; Kahnt, A.S.; Kaiser, A.; Proschak, A.; Steinhilber, D.; Pogoryelov, D.; Wagner, K.; Hammock, B.D.; Proschak, E.
Journal Article
2019CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium
Linke, B.; Meyer Dos Santos, S.; Picard-Willems, B.; Keese, M.; Harder, S.; Geisslinger, G.; Scholich, K.
Journal Article
2019Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation
Maric, J.; Ravindran, A.; Mazzurana, L.; Acker, A. van; Rao, A.; Kokkinou, E.; Ekoff, M.; Thomas, D.; Fauland, A.; Nilsson, G.; Wheelock, C.E.; Dahlen, S.-E.; Ferreiros, N.; Geisslinger, G.; Friberg, D.; Heinemann, A.; Konya, V.; Mjösberg, J.
Journal Article
2019A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients with Dementia
Gurke, R.; Etyemez, S.; Prvulovic, D.; Thomas, D.; Fleck, S.C.; Reif, A.; Geisslinger, G.; Lötsch, J.
Journal Article
2019Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics
Gurke, R.; Thomas, D.; Schreiber, Y.; Schäfer, S.M.G.; Fleck, S.C.; Geisslinger, G.; Ferreiros, N.
Journal Article
2019GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells
Wegner, M.-S.; Gruber, L.; Schömel, N.; Trautmann, S.; Brachtendorf, S.; Fuhrmann, D.; Schreiber, Y.; Olesch, C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2019Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab
Mojtahed Poor, S.; Ulshöfer, T.; Gabriel, L.A.; Henke, M.; Köhm, M.; Behrens, F.; Geisslinger, G.; Parnham, M.J.; Burkhardt, H.; Schiffmann, S.
Journal Article
2019Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice
Möser, C.V.; Möller, M.; Fleck, S.C.; Thomas, D.; Geisslinger, G.; Niederberger, E.
Journal Article
2019The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated
Bazarganipour, S.; Hausmann, J.; Oertel, S.; El-Hindi, K.; Brachtendorf, S.; Blumenstein, I.; Kubesch, A.; Sprinzl, K.; Birod, K.; Hahnefeld, L.; Trautmann, S.; Thomas, D.; Herrmann, E.; Geisslinger, G.; Schiffmann, S.; Grösch, S.
Journal Article
2019Novel Approaches to Persistent Pain Therapy
Sisignano, M.; Parnham, M.J.; Geisslinger, G.
Journal Article
2019Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
Schwarzkopf, K.M.; Queck, A.; Thomas, D.; Angioni, C.; Cai, C.; Freygang, Y.; Rüschenbaum, S.; Geisslinger, G.; Zeuzem, S.; Welsch, C.; Lange, C.M.
Journal Article
2019Potential biomarkers for persistent and neuropathic pain therapy
Sisignano, M.; Lötsch, J.; Parnham, M.J.; Geisslinger, G.
Journal Article
2019Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001
Nothnagel, L.; Jung, F.; Rossmanith, T.; Thurn, M.; Ashtikar, M.; Geisslinger, G.; Parnham, M.J.; Wacker, M.G.
Journal Article
2019Reduced neuropathic pain behavior in mice lacking the cyclic nucleotide-gated channel subunit CNGB1
Kallenborn-Gerhardt, W.; Lu, R.; Petersen, J.J.; Metzner, K.; Kuth, M.S.; Heine, S.; Drees, O.; Paul, M.; Becirovic, E.; Kennel, L.; Flauaus, C.; Gross, T.; Wack, G.; Hohmann, S.W.; Turco, D. del; Biel, M.; Geisslinger, G.; Michalakis, S.; Schmidtko, A.
Abstract
2019Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes
Kurz, J.; Barthelmes, J.; Blum, L.; Ulshöfer, T.; Wegner, M.-S.; Ferreiros, N.; Roser, L.; Geisslinger, G.; Grösch, S.; Schiffmann, S.
Journal Article
2019Selective Inactivation of Cancer Drugs by SAMHD1 Provides a Molecular Rationale for Therapeutic Stratification in AML
Schneider, C.; Oellerich, T.; Knecht, K.M.; Thomas, D.; Buzovetsky, O.; Schliemann, C.; Bohnenberger, H.; Angenendt, L.; Hartmann, W.; Wardelmann, E.; Scheich, S.; Comoglio, F.; Wilke, A.; Ströbel, P.; Serve, H.; Geisslinger, G.; Keppler, O.T.; Xiong, Y.; Cinatl, J.
Abstract
2019Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML
Oellerich, T.; Schneider, C.; Thomas, D.; Knecht, K.M.; Buzovetsky, O.; Kaderali, L.; Schliemann, C.; Bohnenberger, H.; Angenendt, L.; Hartmann, W.; Wardelmann, E.; Rothenburger, T.; Mohr, S.; Scheich, S.; Comoglio, F.; Wilke, A.; Ströbel, P.; Serve, H.; Michaelis, M.; Ferreiros, N.; Geisslinger, G.; Xiong, Y.; Keppler, O.T.; Cinatl, J.
Journal Article
2019Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder
Brunkhorst-Kanaan, N.; Klatt-Schreiner, K.; Hackel, J.; Schröter, K.; Trautmann, S.; Hahnefeld, L.; Wicker, S.; Reif, A.; Thomas, D.; Geisslinger, G.; Kittel-Schneider, S.; Tegeder, I.
Journal Article
2019Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation
Tarighi, N.; Menger, D.; Pierre, S.; Kornstädt, L.; Thomas, D.; Ferreiros, N.; Nüsing, R.M.; Geisslinger, G.; Scholich, K.
Journal Article
2019A validated LC-MS/MS method for the determination of homocysteic acid in biological samples
Gurke, R.; Schmidt, D.; Thomas, D.; Fleck, S.C.; Geisslinger, G.; Ferreiros, N.
Journal Article
2019Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ
Göbel, T.; Diehl, O.; Heering, J.; Merk, D.; Angioni, C.; Wittmann, S.K.; Buscato, E. la; Kottke, R.; Weizel, L.; Schader, T.; Maier, T.J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Steinhilber, D.; Proschak, E.; Kahnt, A.S.
Journal Article
2018Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Pleli, T.; Mondorf, A.; Ferreiros, N.; Thomas, D.; Dvorak, K.; Biondi, R.M.; Heringdorf, D.M.; Zeuzem, S.; Geisslinger, G.; Zimmermann, H.; Waidmann, O.; Piiper, A.
Journal Article
2018Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
Ringleb, J.; Strack, E.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Weigert, A.; Brüne, B.
Journal Article
2018Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigrudsson, T.; Hauser, M.J.; Tenzer, S.; Distler, U.; Aoki, J.; Morris, A.J.; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, H.J.; Radyushkin, K.; Nitsch, R.; Vogt, J.
Journal Article
2018Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigrudsson, T.; Hauser, M.J.; Tenzer, S.; Distler, U.; Aoki, J.; Morris, A.J.; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, H.J.; Radyushkin, K.; Nitsch, R.; Vogt, J.
Journal Article
2018Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology
Schierle, S.; Flauaus, C.; Heitel, P.; Willems, S.; Schmidt, J.; Kaiser, A.; Weizel, L.; Goebel, T.; Kahnt, A.S.; Geisslinger, G.; Steinhilber, D.; Wurglics, M.; Rovati, G.E.; Schmidtko, A.; Proschak, E.; Merk, D.
Journal Article
2018Bovine embryo elongation is altered due to maternal fatty acid supplementation
Giller, K.; Drews, B.; Berard, J.; Kienberger, H.; Schmicke, M.; Frank, J.; Spanier, B.; Daniel, H.; Geisslinger, G.; Ulbrich, S.E.
Journal Article
2018Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
Brachtendorf, S.; Wanger, R.A.; Birod, K.; Thomas, D.; Trautmann, S.; Wegner, M.-S.; Fuhrmann, D.C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2018Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression
Blum, L.; Tafferner, N.; Spring, I.; Kurz, J.; deBruin, N.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
Journal Article
2018Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase
Roos, J.; Peters, M.; Maucher, I.V.; Kühn, B.; Fettel, J.; Hellmuth, N.; Brat, C.; Sommer, B.; Urbschat, A.; Piesche, M.; Vogel, A.; Proschak, E.; Blöcher, R.; Buscató, E.; Häfner, A.-K.; Matrone, C.; Werz, O.; Heidler, J.; Wittig, I.; Angioni, C.; Geisslinger, G.; Parnham, M.J.; Zacharowski, K.; Steinhilber, D.; Maier, T.J.
Journal Article
2018The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue
Kern, K.; Schäfer, S.M.G; Cohnen, J.; Pierre, S.; Osthues, T.; Tarighi, N.; Hohmann, S.; Ferreiros, N.; Brüne, B.; Weigert, A.; Geisslinger, G.; Sisignano, M.; Scholich, K.
Journal Article
2018The histone demethylase Jarid1b mediates angiotensin II‐induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase
Vasconez, A.E.; Janetzko, P.; Oo, J.A.; Pflüger‐Müller, B.; Ratiu, C.; Gu, L.; Helin, K.; Geisslinger, G.; Fleming, I.; Schröder, K.; Fork, C.; Brandes, R.P.; Leisegang, M.S.
Journal Article
2018An in vitro test system for compounds that modulate human inflammatory macrophage polarization
Shiratori, H.; Feinweber, C.; Luckhardt, S.; Wallner, N.; Geisslinger, G.; Weigert, A.; Parnham, M.J.
Journal Article
2018Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin
Kringel, D.; Geisslinger, G.; Resch, E.; Oertel, B.G.; Thrun, M.C.; Heinemann, S.; Lötsch, J.
Journal Article
2018Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy
Lötsch, J.; Schiffmann, S.; Schmitz, K.; Brunkhorst, R.; Lerch, F.; Ferreiros, N.; Wicker, S.; Tegeder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2018Mast cell tetrahydrobiopterin contributes to itch in mice
Zschiebsch, K.; Fischer, C.; Wilken‐Schmitz, A.; Geisslinger, G.; Channon, K.; Watschinger, K.; Tegeder, I.
Journal Article
2018Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses
Zezina, E.; Snodgrass, R.G.; Schreiber, Y.; Zukunft, S.; Schürmann, C.; Meyer zu Heringdorff, D.; Geisslinger, G.; Fleming, I.; Brandes, R.P.; Brüne, B.; Namgaladze, D.
Journal Article
2018Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains
Bruin, N. de; Ferreirós, N.; Schmidt, M.; Hofmann, M.; Angioni, C.; Geisslinger, G.; Parnham, M.J.
Journal Article
2018Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation
Hofmann, M.C.J.; Schmidt, M.; Arne, O.; Geisslinger, G.; Parnham, M.J.; Bruin, N.M.W.J. de
Journal Article
2018A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages
Snodgrass, R.G.; Zezina, E.; Namgaladze, D.; Gupta, S.; Angioni, C.; Geisslinger, G.; Lütjohann, D.; Brüne, B.
Journal Article
2018The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain
Zimmer, B.; Angioni, C.; Osthues, T.; Toewe, A.; Thomas, D.; Pierre, S.C.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
2018Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
Hitzel, J.; Lee, E.; Zhang, Y.; Bibli, S.I.; Li, X.; Zukunft, S.; Pflüger, B.; Hu, J.; Schürmann, C.; Vasconez, A.E.; Oo, J.A.; Kratzer, A.; Kumar, S.; Rezende, F.; Josipovic, I.; Thomas, D.; Giral, H.; Schreiber, Y.; Geisslinger, G.; Fork, C.; Yang, X.; Sigala, F.; Romanoski, C.E.; Kroll, J.; Jo, H.; Landmesser, U.; Lusis, A.J.; Namgaladze, D.; Fleming, I.; Leisegang, M.S.; Zhu, J.; Brandes, R.P.
Journal Article
2018Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models
Vollert, J,; Magerl, W.; Baron, R.; Binder, A.; Enax-Krumova, E.; Geisslinger, G.; Gierthmühlen, J.; Henrich, F.; Hüllemann, P.; Klein, T.; Lötsch, J.; Maier, C.; Oertel, B.; Schuh-Hofer, S.; Tölle, T.; Treede, R.-D.
Journal Article
2018The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage
Treutlein, E.-M.; Kern, K.; Weigert, A.; Tarighi, N.; Schuh, C.-D.; Nüsing, R.M.; Schreiber, Y.; Ferreirós, N.; Brüne, B.; Geisslinger, G.; Pierre, S.; Scholich, K.
Journal Article
2018The relevance of ceramides and their synthesizing enzymes for multiple sclerosis
Kurz, J.; Brunkhorst, R.; Foerch, C.; Blum, L.; Henke, M.; Gabriel, L.; Ulshöfer, T.; Ferreiros, N.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
Journal Article
2018Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry
Toewe, A.; Balas, L.; Durand, T.; Geisslinger, G.; Ferreirós, N.
Journal Article
2018Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity
Fettel, J.; Kühn, B.; Guillen, N.A.; Sürün, D.; Peters, M.; Bauer, R.; Angioni, C.; Geisslinger, G.; Schnütgen, F.; Meyer zu Heringdorf, D.; Werz, O.; Meybohm, P.; Zacharowski, K.; Steinhilber, D.; Roos, J.; Maier, T.J.
Journal Article
2018The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
Knecht, K.M.; Buzovetsky, O.; Schneider, C.; Thomas, D.; Srikanth, V.; Kaderali, L.; Tofoleanu, F.; Reiss, K.; Ferreirós, N.; Geisslinger, G.; Batista, V.S.; Ji, X.; Cinatl, J.; Keppler, O.T.; Xiong, Y.
Journal Article
2018Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigurdsson, T.; Hauser, M.J.; Tenzer, S.; Distler, U.; Aoki, J.; Morris, A.J.; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, H.J.; Radyushkin, K.; Nitsch, R.; Vogt, J.
Journal Article
2018UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells
Wegner, M.-S.; Schömel, N.; Gruber, L.; Örtel, S.B.; Kjellberg, M.A.; Mattjus, P.; Kurz, J.; Trautmann, S.; Peng, B.; Wegner, M.; Kaulich, M.; Ahrends, R.; Geisslinger, G.; Grösch, S.
Journal Article
2018The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)
Wegner, M.-S.; Gruber, L.; Mattjus, P.; Geisslinger, G.; Grösch, S.
Journal Article
2017Activated platelets induce an anti-inflammatory response of monocytes/macrophages through cross-regulation of PGE2 and cytokines
Linke, B.; Schreiber, Y.; Picard-Willems, B.; Slattery, P.; Nüsing, R.M.; Harder, S.; Geisslinger, G.; Scholich, K.
Journal Article
2017AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids
King-Himmelreich, T.S.; Möser, C.V.; Wolters, M.C.; Schmetzer, J.; Schreiber, Y.; Ferreirós, N.; Russe, O.Q.; Geisslinger, G.; Niederberger, E.
Journal Article
2017CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages
Kern, K.; Pierre, S.; Schreiber, Y.; Angioni, C.; Thomas, D.; Ferreirós, N.; Geisslinger, G.; Scholich, K.
Journal Article
2017Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice
Oertel, S.; Scholich, K.; Weigert, A.; Thomas, D.; Schmetzer, J.; Trautmann, S.; Wegner, M.S.; Radeke, H.H.; Filmann, N.; Brüne, B.; Geisslinger, G.; Tegeder, I.; Grösch, S.
Journal Article
2017Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles
Kretschmer, S.B.M.; Woltersdorf, S.; Vogt, D.; Lillich, F.F.; Rühl, M.; Karas, M.; Maucher, I.V.; Roos, J.; Häfner, A.-K.; Kaiser, A.; Wurglics, M.; Schubert-Zsilavecz, M.; Angioni, C.; Geisslinger, G.; Stark, H.; Steinhilber, D.; Hofmann, B.
Journal Article
2017Cleavage of SNAP‐25 ameliorates cancer pain in a mouse model of melanoma
Olbrich, K.; Costard, L.; Möser, C.V.; Syhr, K.M.J.; King‐Himmelreich, T.S.; Wolters, M.C.; Schmidtko, A.; Geisslinger, G.; Niederberger, E.
Journal Article
2017Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase
Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Blöcher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fürst, R.; Proschak, E.
Journal Article
2017Drugging the pain epigenome
Niederberger, E.; Resch, E.; Parnham, M.J.; Geisslinger, G.
Journal Article
2017A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter nonalcoholic steatohepatitis
Schmidt, J.; Rotter, M.; Weiser, T.; Wittmann, S.; Weizel, L.; Kaiser, A.; Heering, J.; Goebel, T.; Angioni, C.; Wurglics, M.; Paulke, A.; Geisslinger, G.; Kahnt, A.; Steinhilber, D.; Proschak, E.; Merk, D.
Journal Article
2017Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis
Schmitz, K.; Brunkhorst, R.; Bruin, N. de; Mayer, C.A.; Häussler, A.; Ferreiros, N.; Schiffmann, S.; Parnham, M.J.; Tunaru, S.; Chun, J.; Offermanns, S.; Foerch, C.; Scholich, K.; Vogt, J.; Wicker, S.; Lötsch, J.; Geisslinger, G.; Tegeder, I.
Journal Article
2017The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity
Hohmann, S.W.; Angioni, C.; Tunaru, S.; Lee, S.; Woolf, C.J.; Offermanns, S.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
2017GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation
Pierre, S.; Linke, B.; Suo, J.; Tarighi, N.; Turco, D. del; Thomas, D.; Ferreiros, N.; Stegner, D.; Frölich, S.; Sisignano, M.; Santos, S.M. dos; Debruin, N.; Nüsing, R.M.; Deller, T.; Nieswandt, B.; Geisslinger, G.; Scholich, K.
Journal Article
2017Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain
Grösch, S.; Niederberger, E.; Geisslinger, G.
Journal Article
2017The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons
Zinn, S.; Sisignano, M.; Kern, K.; Pierre, S.; Tunaru, S.; Jordan, H.; Suo, J.; Treutlein, E.M.; Angioni, C.; Ferreiros, N.; Leffler, A.; DeBruin, N.; Offermanns, S.; Geisslinger, G.; Scholich, K.
Journal Article
2017Machine-learned data structures of lipid marker serum concentrations in multiple sclerosis patients differ from those in healthy subjects
Lötsch, J.; Thrun, M.; Lerch, F.; Brunkhorst, R.; Schiffmann, S.; Thomas, D.; Tegder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2017Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418
Maucher, I.V.; Rühl, M.; Kretschmer, S.B.M.; Hofmann, B.; Kühn, B.; Fettel, J.; Vogel, A.; Flügel, K.-T.; Manolikakes, G.; Hellmuth, N.; Häfner, A.-K.; Golghalyani, V.; Ball, A.K.; Piesche, M.; Matrone, C.; Geisslinger, G.; Parnham, M.J.; Karas, M.; Steinhilber, D.; Roos, J.; Maier, T.J.
Journal Article
2017Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis
Schmitz, K.; Geisslinger, G.; Tegeder, I.
Journal Article
2017Oxidized lipids in the treatment of chronic or neuropathic pain
Sisignano, Marco; Geisslinger, Gerd; Parnham, Michael John
Patent
2017Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B–induced local skin hypersensitization in healthy subjects
Lötsch, J.; Geisslinger, G.; Heinemann, S.; Lerch, F.; Oertel, B.G.; Ultsch, A.
Journal Article
2017R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4
Wobst, I.; Ebert, L.; Birod, K.; Wegner, M.-S.; Hoffmann, M.; Thomas, D.; Angioni, C.; Parnham, M.J.; Steinhilber, D.; Tegeder, I.; Geisslinger, G.; Grösch, S.
Journal Article
2017Rab7 - A novel redox target that modulates inflammatory pain processing
Kallenborn-Gerhardt, W.; Möser, C.V.; Lorenz, J.E.; Steger, M.; Heidler, J.; Scheving, R.; Petersen, J.; Kennel, L.; Flauaus, C.; Lu, R.; Edinger, A.L.; Tegeder, I.; Geisslinger, G.; Heide, H.; Wittig, I.; Schmidtko, A.
Journal Article
2017SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
Schneider, C.; Oellerich, T.; Baldauf, H.-M.; Schwarz, S.-M.; Thomas, D.; Flick, R.; Bohnenberger, H.; Kaderali, L.; Stegmann, L.; Cremer, A.; Martin, M.; Lohmeyer, J.; Michaelis, M.; Hornung, V.; Schliemann, C.; Berdel, W.E.; Hartmann, W.; Wardelmann, E.; Comoglio, F.; Hansmann, M.L.; Yakunin, A.F.; Geisslinger, G.; Ströbel, P.; Ferreiros, N.; Serve, H.; Keppler, O.T.; Cinatl, J.
Journal Article
2017Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction
Schwalm, S.; Beyer, S.; Frey, H.; Haceni, R.; Grammatikos, G.; Thomas, D.; Geisslinger, G.; Schaefer, L.; Huwiler, A.; Pfeilschifter, J.
Journal Article
2017THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro
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Abstract
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Abstract
2015Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils
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Patent
2014Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity
Kallenborn-Gerhardt, W.; Hohmann, S.W.; Syhr, K.M.J.; Schröder, K.; Sisignano, M.; Weigert, A.; Lorenz, J.E.; Lu, R.R.; Brüne, B.; Brandes, R.P.; Geisslinger, G.; Schmidtko, A.
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Abstract
2014Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury
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Abstract
2014TRP-channels as key integrators of lipid pathways in nociceptive neurons
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