Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Genome Editing in Agriculture: Technical and Practical Considerations
Jansing, Julia; Schiermeyer, Andreas; Schillberg, Stefan; Fischer, Rainer; Bortesi, Luisa
Journal Article
2019The Integration of Algal Carbon Concentration Mechanism Components into Tobacco Chloroplasts Increases Photosynthetic Efficiency and Biomass
Nölke, G.; Barsoum, M.; Houdelet, M.; Arcalis, E.; Kreuzaler, F.; Fischer, R.; Schillberg, S.
Journal Article
2019Laccase-induced HBT-grafting to milled beech wood reduces unspecific protein adsorption
Jestel, T.; Roth, S.; Heesel, D.; Kress, A.; Fischer, R.; Spiess, A.C.
Journal Article
2019Targeted insertion of large DNA sequences by homology-directed repair or non-homologous end joining in engineered tobacco BY-2 cells using designed zinc finger nucleases
Schiermeyer, Andreas; Schneider, Katja; Kirchhoff, Janina; Schmelter, Thomas; Koch, Natalie; Ke, Jiang; Herwartz, Denise; Blue, Ryan; Marri, Pradeep; Samuel, Pon; Corbin, David R.; Webb, Steven R.; Gonzalez, Delkin O.; Folkerts, Otto; Fischer, Rainer; Schinkel, Helga; Ainley, W. Michael; Schillberg, Stefan
Journal Article
2018Beyond data quality. Data excellence challenges from an enterprise, research and city perspective
Sautter, Johannes; Litauer, Rebecca; Fischer, Rudolf; Klages, Tina; Wuchner, Andrea; Müller, Elena; Schaj, Gretel; Dobrokhotova, Ekaterina; Drews, Patrick; Riess, Stefan
Conference Paper
2018Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites
Chouman, Karinna; Korioth-Schmitz, Birgit; Sack, Markus; Engelbert Schmitz, Jörn; Tuan Pham, Anh; Fischer, Rainer; Barth, Stefan; Klockenbring, Torsten; Fendel, Rolf
Journal Article
2018Downstream processing of a plant-derived malaria transmission-blocking vaccine candidate
Menzel, S.; Holland, T.; Boes, A.; Spiegel, H.; Fischer, R.; Buyel, J.F.
Journal Article
2018Elimination of different leukaemia subtypes using novel CD89-specific human cytolytic fusion proteins
Gresch, G.; Schenke, L.; Mladenov, R.; Zwirner, S.; Cremer, C.; Niesen, J.; Grieger, E.; Brümmendorf, T.; Jost, E.; Fischer, R.; Stockmeyer, B.; Barth, S.; Nachreiner, T.; Stein, C.
Journal Article
2018Fabrication and characterization of bending-independent capacitive CMOS pressure sensor stacks
Fischer, Roland; Ditler, Heinrich; Görtz, Michael; Mokwa, Wilfried
Journal Article, Conference Paper
2018Stable and highly conductive carbon nanotube enhanced PEDOT:PSS as transparent electrode for flexible electronics
Fischer, R.; Gregori, A.; Sahakalkan, S.; Hartmann, D.; Büchele, P.; Tedde, S.F.; Schmidt, O.
Journal Article
2017Antibodies from plants for bionanomaterials
Edgue, G.; Twyman, R.M.; Beiss, V.; Fischer, R.; Sack, M.
Journal Article
2017Characteristics of Genome Editing Mutations in Cereal Crops
Zhu, C.; Bortesi, L.; Baysal, C.; Twyman, R.M.; Fischer, R.; Capell, T.; Schillberg, S.; Christou, P.
Journal Article
2017Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants
Havenith, Heide; Kern, Karolin; Rautenberger, Paul; Spiegel, Holger; Szardenings, Michael; Ueberham, Elke; Lehmann, Jörg; Buntru, Matthias; Vogel, Simon; Treudler, Regina; Fischer, Rainer; Schillberg, Stefan
Journal Article
2017Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells
Woitok, M.; Klose, D.; Fiore, S. di; Richter, W.; Stein, C.; Gresch, G.; Grieger, E.; Barth, S.; Fischer, R.; Kolberg, K.; Niesen, J.
Journal Article
2017Contained molecular farming using plant cell and tissue cultures
Schillberg, S.; Raven, Nicole; Fischer, R.; Twyman, R.M.; Schiermeyer, A.
Book Article
2017Detection and Specific Elimination of EGFR+ Ovarian Cancer Cells Using a Near Infrared Photoimmunotheranostic Approach
Bauerschlag, D.; Meinhold-Heerlein, I.; Maass, N.; Bleilevens, A.; Bräutigam, K.; Al Rawashdeh, W.; Di Fiore, S.; Haugg, A.M.; Gremse, F.; Steitz, J.; Fischer, R.; Stickeler, E.; Barth, S.; Hussain, A.F.
Journal Article
2017Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases
Zischewski, J.; Fischer, R.; Bortesi, L.
Journal Article
2017The digestive and defensive basis of carcass utilization by the burying beetle and its microbiota
Vogel, H.; Shukla, S.P.; Engl, T.; Weiss, B.; Fischer, R.; Steiger, S.; Heckel, D.G.; Kaltenpoth, M.; Vilcinskas, A.
Journal Article
2017Discovery and validation of immunological biomarkers in milk for health monitoring of dairy cows
Zoldan, Katharina; Schneider, Josephine; Möllmer, T.; Füldner, Christiane; Knauer, Jens; Fürll, M.; Starke, A.; Specht, Michael; Hackermüller, Jörg; Kalkhof, Stefan; Bergen, M. von; Bergfeld, U.; Fischer, R.; Pache, S.; Lehmann, Jörg
Journal Article
2017DRUGAS: Implantable telemetric system for measuring the portal venous pressure: Assembly aspects
Fischer, Roland; Weidenmüller, Jens; Görtz, Michael; Göttsche, Thorsten; Mokwa, Wilfried
Journal Article
2017Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13-ETA ' and the bispecific scFv [13xds16]
Grieger, E.; Gresch, G.; Niesen, J.; Woitok, M.; Barth, S.; Fischer, R.; Fendel, R.; Stein, C.
Journal Article
2017Encapsulation of nor-beta-lapachone into poly(d,l)-lactide-: Co -glycolide (PLGA) microcapsules: Full characterization, computational details and cytotoxic activity against human cancer cell lines
Costa, M.P.; Feitosa, A.C.S.; Oliveira, F.C.E.; Cavalcanti, B.C.; Dias, G.G.; Caetano, E.W.S.; Sales, F.A.M.; Freire, V.N.; Fiore, S. di; Fischer, R.; Ladeira, L.O.; Silva Junior, E.N. da; Pessoa, C.
Journal Article
2017Fine Tuning Antibody Conjugation Methods using SNAP-tag Technology
Chouman, K.; Woitok, M.; Mladenov, R.; Kessler, C.; Weinhold, E.; Hanz, G.; Fischer, R.; Meinhold-Heerlein, I.; Bleilevens, A.; Gresch, G.; Haugg, A.M.; Zeppernick, F.; Bauerschlag, D.; Maass, N.; Stickeler, E.; Kolberg, K.; Hussain, A.F.
Journal Article
2017Gedünnte kapazitive Silizium-Drucksensoren in flexiblen und dehnbaren extra weichen Substraten für haptische Messungen
Fischer, Roland; Weichsel, Lisa; Mokwa, Wilfried; Görtz, Michael
Conference Paper
2017Generation of an artificial human B cell line test system using Transpo-mAb (TM) technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins
Klose, D.; Woitok, M.; Niesen, J.; Beerli, R.R.; Grawunder, U.; Fischer, R.; Barth, S.; Fendel, R.; Nachreiner, T.
Journal Article
2017Heterologous expression of a Streptomyces cyaneus laccase for biomass modification applications
Ece, S.; Lambertz, C.; Fischer, R.; Commandeur, U.
Journal Article
2017Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candiate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRpm2 Does Not Improve the In Vitro Efficacy
Spiegel, H.; Boes, A.; Fendel, R.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2017Improvement of a fermentation process for the production of two PfAMA1-DiCo-based malaria vaccine candidates in Pichia pastoris
Kastilan, R.; Boes, A.; Spiegel, H.; Voepel, N.; Chudobova, I.; Hellwig, S.; Buyel, J.F.; Reimann, A.; Fischer, R.
Journal Article
2017Naturkautschuk aus Russischem Löwenzahn
Fischer, R.; Schulze Gronover, C.; Prüfer, D.
Book Article
2017Novel PSCA targeting scFv-fusion proteins for diagnosis and immunotherapy of prostate cancer
Kessler, C.; Pardo, A.; Tur, M.K.; Gattenlöhner, S.; Fischer, R.; Kolberg, K.; Barth, S.
Journal Article
2017Optimized detection and decoding of 4D signals for the nonlinear fiber-optical channel
Frey, F.; Wäckerle, F.; Fischer, J.K.; Fischer, R.F.H.
Conference Paper
2017Single-step Perturbation-based Nonlinearity Compensation of Intra- and Inter-Subcarrier Nonlinear Interference
Frey, F.; Molle, L.; Emmerich, R.; Schubert, C.; Fischer, J.K.; Fischer, R.F.H.
Conference Paper
2017Toward Discovery of Novel Microtubule Targeting Agents
Berges, N.; Arens, K.; Kreusch, V.; Fischer, R.; Fiore, S. di
Journal Article
2017Very-large-scale production of antibodies in plants: The biologization of manufacturing
Buyel, J.F.; Twyman, R.M.; Fischer, R.
Journal Article
2016Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria
Addai-Mensah, O.; Seidel, M.; Amidu, N.; Maskus, DJ.; Kapelski, S.; Breuer, G.; Franken, C.; Owusu-Dabo, E.; Frempong, M.; Rakotozandrindrainy, R.; Schinkel, H.; Reimann, A.; Klockenbring, T.; Barth, S.; Fischer, R.; Fendel, R.
Journal Article
2016Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail
Boes, A.; Spiegel, H.; Kastilan, R.; Bethke, S.; Voepel, N.; Chudobova, I.; Bolscher, J.M.; Dechering, K.J.; Fendel, R.; Buyel, J.F.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2016Anti-Parasitic Complexes
Fendel, Rolf; Kapelski, Stephanie; Barth, Stefan; Fischer, Rainer; Reimann, Andreas
Patent
2016Anti-plasmodium parasite antibodies
Fischer, Rainer; Reimann, Andreas; Maskus, Dominika Jacqueline; Fendel, Rolf; Klockenbring, Torsten
Patent
2016Antibody-Mediated Pathogen Resistance in Plants
Peschen, D.; Schillberg, S.; Fischer, R.
Book Article
2016CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo
Mladenov, R.; Hristodorov, D.; Cremer, C.; Gresch, G.; Grieger, G.; Schenke, L.; Klose, D.; Amoury, M.; Woitok, M.; Jost, E.; Brümmerdorf, T.H.; Fendel, R.; Fischer, R.; Stein, C.; Thepen, T.; Barth, S.
Journal Article
2016Characterization of a novel inhibitory human monoclonal antibody directed against Plasmodium falciparum Apical Membrane Antigen 1
Maskus, D.J.; Królik, M.; Bethke, S.; Spiegel, H.; Kapelski, S.; Seidel, M.; Addai-Mensah, O.; Reimann, A.; Klockenbring, T.; Barth, S.; Fischer, R.; Fendel, R.
Journal Article
2016Comparison of tobacco host cell protein removal methods by blanching intact plants or by heat treatment of extracts
Buyel, J.F.; Hubbuch, J.; Fischer, R.
Journal Article
2016Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells
Costa, M.P.; Feitosa, A.C.S.; Oliveira, F.C.E.; Cavalcanti, B.C.; Da Silva, E.N., Jr.; Dias, G.G.; Sales, F.A.M.; Sousa, B.L.; Barroso-Neto, I.L.; Pessoa, C.; Caetano, E.W.S.; Di Fiore, S.; Fischer, R.; Ladeira, L.O.; Freire, V.N.
Journal Article
2016Crystal Growth, Crystal Structure, Optical Properties, and Phase Transition of BaCaBO3F
Burianek, M.; Teck, M.; Niekamp, C.; Birkenstock, J.; Spieß, I.; Medenbach, O.; Fischer, L.A.; Wolff, P.E.; Neumann, J.; Fischer, R.X.
Journal Article
2016Development of a competitive cystatin C-specific bioassay suitable for repetitive measurements
Damm, T.; Spiegel, H.; Barth, S.; Fischer, R.; Naehring, J.
Journal Article
2016Developments in the production of mucosal antibodies in plants
Vasilev, Nikolay; Smales, C. Mark; Schillberg, Stefan; Fischer, Rainer; Schiermeyer, Andreas
Journal Article
2016Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines
Bodewein, L.; Schmelter, F.; Di Fiore, S.; Hollert, H.; Fischer, R.; Fenske, M.
Journal Article
2016The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F
Woitok, M.; Klose, D.; Niesen, J.; Richter, W.; Abbas, M.; Stein, C.; Fendel, R.; Bialon, M.; Püttmann, C.; Fischer, R.; Barth, S.; Kolberg, K.
Journal Article
2016Fully human MAP-fusion protein selectively targets and eliminates proliferating CD64+ M1 macrophages
Hristodorov, D.; Mladenov, R.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2016Genetically modified higher plants with increased photosynthesis and/or biomass production, methods and uses thereof
Kreuzaler, Fritz; Nölke, Greta; Schillberg, Stefan; Barsoum, Mirna; Fischer, Rainer
Patent
2016Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model
Amoury, M.; Kolberg, K.; Pham, A.-T.; Hristodorov, D.; Mladenov, R.; Fiore, S. di; Helfrich, W.; Kiessling, F.; Fischer, R.; Pardo, A.; Thepen, T.; Hussain, A.F.; Nachreiner, T.; Barth, S.
Journal Article
2016Heterologous expression of cellulolytic enzymes
Eckert, C.; Fischer, R.; Commandeur, U.
Book Article
2016Improving the utilization of lignocellulosic biomass by polysaccharide modification
Damm, T.; Commandeur, U.; Fischer, R.; Usadel, B.; Klose, H.
Journal Article
2016Kluyveromyces lactis as an expression host for enzymes that degrade lignocellulosic biomass
Lambertz, C.; Eckert, C.; Fischer, R.; Commandeur, U.
Journal Article
2016Method for providing stable isoindole derivatives
Schramm, Oana Genoveva; Fiore, Stefano di; Fischer, Rainer
Patent
2016Molecular farming
Fischer, R.; Schillberg, S.
Book Article
2016A Monoclonal Antibody That Discriminates between SNAP-Tagged and CLIP-Tagged Proteins
Bialon, M.; Grezella, C.; Friesen, L.; Sieben, T.; Pham, A.-T.; Fischer, R.; Barth, S.; Püttmann, C.; Stein, C.
Journal Article
2016More for less: Improving the biomass yield of a pear cell suspension culture by design of experiments
Rasche, S.; Herwartz, D.; Schuster, F.; Jablonka, N.; Weber, A.; Fischer, R.; Schillberg, S.
Journal Article
2016Next-generation sequencing of amplicons is a rapid and reliable method for the detection of polymorphisms relevant for barley breeding
Fritsch, L.; Soeur, R.; Hansen, C.; Fischer, R.; Schillberg, S.; Schröper, F.
Journal Article
2016A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein
Amoury, M.; Mladenov, R.; Nachreiner, T.; Pham, A.-T.; Hristodorov, D.; Di Fiore, S.; Helfrich, W.; Pardo, A.; Fey, G.; Schwenkert, M.; Thepen, T.; Kiessling, F.; Hussain, A.F.; Fischer, R.; Kolberg, K.; Barth, S.
Journal Article
2016A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor
Niesen, J.; Hehmann-Titt, G.; Woitok, M.; Fendel, R.; Barth, S.; Fischer, R.; Stein, C.
Journal Article
2016Novel fusion proteins for the antigen-specific staining and elimination of B cell receptor-positive cell populations demonstrated by a tetanus toxoid fragment C (TTC) model antigen
Klose, D.; Saunders, U.; Barth, S.; Fischer, R.; Jacobi, A.M.; Nachreiner, T.
Journal Article
2016Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant-derived malaria vaccine candidates
Menzel, S.; Holland, T.; Boes, A.; Spiegel, H.; Bolzenius, J.; Fischer, R.; Buyel, J.F.
Journal Article
2016Overcoming low yields of plant-made antibodies by a protein engineering approach
Zischewski, J.; Sack, M.; Fischer, R.
Journal Article
2016Patterns of CRISPR/Cas9 activity in plants, animals and microbes
Bortesi, L.; Zhu, C.; Zischewski, J.; Perez, L.; Bassié, L.; Nadi, R.; Forni, G.; Lade, S.B.; Soto, E.; Jin, X.; Medina, V.; Villorbina, G.; Munoz, P.; Farré, G.; Fischer, R.; Twyman, R.M.; Capell, T.; Christou, P.; Schillberg, S.
Journal Article
2016Peak-to-average-power reduction for FBMC-based systems
Eldessoki, Sameh; Dommel, Johannes; Hassan, Khaled; Thiele, Lars; Fischer, Robert F.H.
Conference Paper
2016Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand
Amoury, M.; Bauerschlag, D.; Zeppernick, F.; Felbert, V.; Berges, N.; Fiore, S.D.; Mintert, I.; Bleilevens, A.; Maass, N.; Bräutigam, K.; Meinhold-Heerlein, I.; Stickeler, E.; Barth, S.; Fischer, R.; Hussain, A.F.
Journal Article
2016Phototheranostics immunoconjugates to detect eliminate triple negative breast cancer cells
Hussain, A.; Zeppernick, E.; Amoury, M.; Bauerschlag, D.O.; Maass, N.; Bräutigam, K.; Meinhold-Heerlein, I.; Fischer, R.; Barth, S.
Abstract
2016A Plant-Based Transient Expression System for the Rapid Production of Malaria Vaccine Candidates
Boes, A.; Reimann, A.; Twyman, R.M.; Fischer, R.; Schillberg, S.; Spiegel, H.
Book Article
2016The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement
Rosa, T.F.A.; Flammersfeld, A.; Ngwa, C.J.; Kiesow, M.; Fischer, R.; Zipfel, P.F.; Skerka, C.; Pradel, G.
Journal Article
2016Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins
Arfi, Z.A.; Hellwig, S.; Drossard, J.; Fischer, R.; Buyel, J.F.
Journal Article
2016Production of immunoabsorbent nanoparticles by displaying single-domain protein A on potato virus X
Uhde-Holzem, K.; McBurney, M.; Tiu, B.D.B.; Advincula, R.C.; Fischer, R.; Commandeur, U.; Steinmetz, N.F.
Journal Article
2016Progress and obstacles in the production and application of recombinant lignin-degrading peroxidases
Lambertz, C.; Ece, S.; Fischer, R.; Commandeur, U.
Journal Article
2016Putting the spotlight back on plant suspension cultures
Santos, R.B.; Abranches, R.; Fischer, R.; Sack, M.; Holland, T.
Journal Article
2016SNAP-Tag Technology: A Useful Tool to Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments
Niesen, J.; Sack, M.; Seidel, M.; Fendel, R.; Barth, S.; Fischer, R.; Stein, C.
Journal Article
2016Specific photoimmuno-theranostics for detection and elimination of skin cancer cells
Barth, Stefan; Fischer, Rainer; Hussain, Ahmad
Patent
2016Statistical experimental designs for the production of secondary metabolites in plant cell suspension cultures
Schmitz, C.; Fritsch, L.; Fischer, R.; Schillberg, S.; Rasche, S.
Journal Article
2016Structured plant metabolomics for the simultaneous exploration of multiple factors
Vasilev, N.; Boccard, J.; Lang, G.; Grömping, U.; Fischer, R.; Goepfert, S.; Rudaz, S.; Schillberg, S.
Journal Article
2016Targeted gene exchange in plant cells mediated by a zinc finger nuclease double cut
Schneider, Katja; Schiermeyer, Andreas; Dolls, Anja; Koch, Natalie; Herwartz, Denise; Kirchhoff, Janina; Fischer, Rainer; Russell, Sean M.; Cao, Zehui; Corbin, David R.; Sastry-Dent, Lakshmi; Ainley, W. Michael; Webb, Steven R.; Schinkel, Helga; Schillberg, Stefan
Journal Article
2016Utilizing Regulatory Networks for Pluripotency Assessment in Stem Cells
Brändl, B.; Schuldt, B.M.; Böhnke, L.; Keminer, O.; Vaas, L.A.I.; Fischer, R.; Müller, F.-J.; Pless, O.
Journal Article
2015Analysis of a multi-component multi-stage malaria vaccine candidate-tackling the cocktail challenge
Boes, A.; Spiegel, H.; Voepel, N.; Edgue, G.; Beiss, V.; Kapelski, S.; Fendel, R.; Scheuermayer, M.; Pradel, G.; Bolscher, J.M.; Behet, M.C.; Dechering, K.J.; Hermsen, C.C.; Sauerwein, R.W.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Angiogenin mutants as novel effector molecules for the generation of fusion proteins with increased cytotoxic potential
Cremer, C.; Vierbuchen, T.; Hein, L.; Fischer, R.; Barth, S.; Nachreiner, T.
Journal Article
2015Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein
Kapelski, S.; Almeida, M. de; Fischer, R.; Barth, S.; Fendel, R.
Journal Article
2015Application of a scalable plant transient gene expression platform for malaria vaccine development
Spiegel, H.; Boes, A.; Voepel, N.; Beiss, V.; Edgue, G.; Rademacher, T.; Sack, M.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Cell wall modification in tobacco by differential targeting of recombinant endoglucanase from Trichoderma reesei
Klose, H.; Günl, M.; Usadel, B.; Fischer, R.; Commandeur, U.
Journal Article
2015Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins
Buyel, J.F.; Opdensteinen, P.; Fischer, R.
Journal Article
2015Characteristics of flexibility in metal-organic framework solid solutions of composition [Zn2(BME-bdc)x(DB-bdc)2-xdabco]n
Bon, Volodymyr; Pallmann, Julia; Eisbein, Emanuel; Hoffmann, Herbert C.; Senkovska, Irena V.; Schwedler, Inke; Schneemann, Andreas; Henke, Sebastian; Wallacher, Dirk; Fischer, Roland A.; Seifert, Gotthard; Brunner, Eike; Kaskel, Stefan
Journal Article
2015Comparison of Thermobifida fusca cellulases expressed in Escherichia coli and Nicotiana tabacum indicates advantages of the plant system for the expression of bacterial cellulases
Klinger, J.; Fischer, R.; Commandeur, U.
Journal Article
2015The CRISPR/Cas9 system for plant genome editing and beyond. Review
Bortesi, L.; Fischer, R.
Journal Article
2015Depth filters containing diatomite achieve more efficient particle retention than filters solely containing cellulose fibers
Buyel, J.F.; Gruchow, H.M.; Fischer, R.
Journal Article
2015Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits
Boes, A.; Spiegel, H.; Edgue, G.; Kapelski, S.; Scheuermayer, M.; Fendel, R.; Remarque, E.; Altmann, F.; Maresch, D.; Reimann, A.; Pradel, G.; Schillberg, S.; Fischer, R.
Journal Article
2015Extraction and downstream processing of plant-derived recombinant proteins
Buyel, J.F.; Twyman, R.M.; Fischer, R.
Journal Article
2015Fast track antibody V-gene rescue, recombinant expression in plants and characterization of a PfMSP4-specific antibody
Kapelski, S.; Boes, A.; Spiegel, H.; Almeida, M. de; Klockenbring, T.; Reimann, A.; Fischer, R.; Barth, S.; Fendel, R.
Journal Article
2015The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia
Mladenov, R.; Hristodorov, D.; Cremer, C.; Hein, L.; Kreutzer, F.; Stroisch, T.; Niesen, J.; Brehm, H.; Blume, T.; Brummendorf, T.H.; Jost, E.; Thepen, T.; Fischer, R.; Stockmeyer, B.; Barth, S.; Stein, C.
Journal Article
2015From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants
Sack, M.; Rademacher, T.; Spiegel, H.; Boes, A.; Hellwig, S.; Drossard, J.; Stoger, E.; Fischer, R.
Journal Article
2015Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein
Beiss, V.; Spiegel, H.; Boes, A.; Kapelski, S.; Scheuermayer, M.; Edgue, G.; Sack, M.; Fendel, R.; Reimann, A.; Schillberg, S.; Pradel, G.; Fischer, R.
Journal Article
2015High-value products from plants: the challenges of process optimization
Fischer, R.; Vasilev, N.; Twyman, R.M.; Schillberg, S.
Journal Article
2015The impact of Pseudomonas syringae type III effectors on transient protein expression in tobacco
Buyel, J.F.; Buyel, J.J.; Haase, C.; Fischer, R.
Journal Article
2015The increasing value of plant-made proteins
Sack, M.; Hofbauer, A.; Fischer, R.; Stoger, E.
Journal Article
2015Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10
Maskus, DJ.; Bethke, S.; Seidel, M.; Kapelski, S.; Addai-Mensah, O.; Boes, A.; Edgu, G.; Spiegel, H.; Reimann, A.; Fischer, R.; Barth, S.; Klockenbring, T.; Fendel, R.
Journal Article
2015A juice extractor can simplify the downstream processing of plant-derived biopharmaceutical proteins compared to blade-based homogenizers
Buyel, J.F.; Fischer, R.
Journal Article
2015Lage, Lage, Lage(r)
: Fischer, R.
Book
2015Next-generation sequencing is a robust strategy for the high-throughput detection of zygosity in transgenic maize
Fritsch, L.; Fischer, R.; Wambach, C.; Dudek, M.; Schillberg, S.; Schroper, F.
Journal Article
2015Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo
Cremer, C.; Braun, H.; Mladenov, R.; Schenke, L.; Cong, X.; Jost, E.; Brümmendorf, T.H.; Fischer, R.; Carloni, P.; Barth, S.; Nachreiner, T.
Journal Article
2015Novel EGFR-specific immunotoxins based on panitumumab and cetuximab show in vitro and ex vivo activity against different tumor entities
Niesen, J.; Stein, C.; Brehm, H.; Hehmann-Titt, G.; Fendel, R.; Melmer, G.; Fischer, R.; Barth, S.
Journal Article
2015Optimization of a multi-stage, multi-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites
Spiegel, H.; Schinkel, H.; Kastilan, R.; Dahm, P.; Boes, A.; Scheuermayer, M.; Chudobova, I.; Maskus, D.; Fendel, R.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Perforin-like protein PPLP4 is crucial for mosquito midgut infection by Plasmodium falciparum
Wirth, C.C.; Bennink, S.; Scheuermayer, M.; Fischer, R.; Pradel, G.
Journal Article
2015Plant expression and characterization of the transmission-blocking vaccine candidate PfGAP50
Beiss, V.; Spiegel, H.; Boes, A.; Scheuermayer, M.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2015Preventing oxidative damage at the early phase: The case of glucose oxidase
Petrovic, D.; Kovacevic, G.; Ostafe, R.; Fischer, R.; Strodel, B.; Prodanovic, R.
Abstract
2015Production of hybrid chimeric PVX particles using a combination of TMV and PVX-based expression vectors
Dickmeis, C.; Honickel, M.M.A.; Fischer, R.; Commandeur, U.
Journal Article
2015Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants
Ma, J.K.-C.; Drossard, J.; Lewis, D.; Altmann, F.; Boyle, J.; Christou, P.; Cole, T.; Dale, P.; van Dolleweerd, C.J.; Isitt, V.; Katinger, D.; Lobedan, M.; Mertens, H.; Paul, M.J.; Rademacher, T.; Sack, M.; Hundleby, P.A.C.; Stiegler, G.; Stoger, E.; Twyman, R.M.; Vcelar, B.; Fischer, R.
Journal Article
2015Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor
Raven, N.; Rasche, S.; Kuehn, C.; Anderlei, T.; Klöckner, W.; Schuster, F.; Henquet, M.; Bosch, D.; Büchs, J.; Fischer, R.; Schillberg, S.
Journal Article
2015Simple and portable magnetic immunoassay for rapid detection and sensitive quantification of plant viruses
Rettcher, S.; Jungk, F.; Kühn, C.; Krause, H.J.; Nölke, G.; Commandeur, U.; Fischer, R.; Schillberg, S.; Schröper, F.
Journal Article
2015Special issue: New generations of porous metal-organic frameworks
Fischer, Roland A.; Kaskel, Stefan; Kitagawa, S.
Abstract
2015The stage-specific in vitro efficacy of a malaria antigen cocktail provides valuable insights into the development of effective multi-stage vaccines
Spiegel, H.; Boes, A.; Kastilan, R.; Kapelski, S.; Edgue, G.; Beiss, V.; Chubodova, I.; Scheuermayer, M.; Pradel, G.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Synthesis and characterization of an insoluble polymer based on polyamidoamine
Valdes, O.; Vergara, C.E.; Camarada, M.B.; Carrasco-Sanchez, V.; Nachtigall, F.M.; Tapia, J.; Fischer, R.; Gonzalez-Nilo, F.D.; Santos, L.S.
Journal Article
2015Synthetic polymers are more effective than natural flocculants for the clarification of tobacco leaf extracts
Buyel, J.F.; Fischer, R.
Journal Article
2015Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein
Brehm, H.; Hristodorov, D.; Pardo, A.; Mladenov, R.; Niesen, J.; Fischer, R.; Tur, M.K.; Barth, S.
Journal Article
2015Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies
Hristodorov, D.; Mladenov, R.; Felbert, V. von; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2015Telemetriesystem zur nichtinvasiven Glukosemessung in der Tränenflüssigkeit
Fischer, Roland; Hennig, Andreas; Lauko, Jan; Wilson, Christopher; Görtz, Michael; Mokwa, Wilfried
Conference Paper
2015Thanatin confers partial resistance against aflatoxigenic fungi in maize (Zea mays)
Schubert, M.; Houdelet, M.; Kogel, K.-H.; Fischer, R.; Schillberg, S.; Nölke, G.
Journal Article
2015The three-dimensional structure of VIM-31-a metallo-beta-lactamase from Enterobacter cloacae in its native and oxidized form
Kupper, M.B.; Herzog, K.; Bennink, S.; Schlomer, P.; Bogaerts, P.; Glupczynski, Y.; Fischer, R.; Bebrone, C.; Hoffmann, K.M.
Journal Article
2015Die vier Ebenen der effizienten Lager-Struktur
Fischer, Roland
Book Article
2015Virus-SiO2 and Virus-SiO2-Au Hybrid Particles with Tunable Morphology
Rijn, P. van; Bezouwen, L.S. van; Fischer, R.; Boekema, E.J.; Böker, A.; Commandeur, U.
Journal Article
2015Vorrichtung und Verfahren zur Überwachung eines Zugriffs auf einen Lagerbereich einer Mehrzahl von Lagerbereichen für Waren
Dräger, Tobias; Fischer, Roland; Mayordomo, Iker; Gundelfinger, Christine; Hartmann, Markus
Patent
2015Yeast surface display is a novel tool for the rapid immunological characterization of plant-derived food allergens
Popovic, M.; Prodanovic, R.; Ostafe, R.; Schillberg, S.; Fischer, R.; Gavrovic-Jankulovic, M.
Journal Article
2014 Recombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody
Hristodorov, D.; Mladenov, R.; Brehm, H.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2014Assessment of Cultivation Factors that Affect Biomass and Geraniol Production in Transgenic Tobacco Cell Suspension Cultures
Vasilev, N.; Schmitz, C.; Grömping, U.; Fischer, R.; Schillberg, S.
Journal Article
2014Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum
Kapelski, S.; Klockenbring, T.; Fischer, R.; Barth, S.; Fendel, R.
Journal Article
2014Challenges and advances in the heterologous expression of cellulolytic enzymes: A review
Lambertz, C.; Garvey, M.; Klinger, J.; Heesel, D.; Klose, H.; Fischer, R.; Commandeur, U.
Journal Article
2014Characterization of complex systems using the design of experiments approach
Buyel, J.F.; Fischer, R.
Journal Article
2014Cloning Murine Antibody V-genes with Non-degenerate Primers and Conversion to a Recombinant Antibody Format
Bialon, M.; Schellenberg, L.; Herzog, N.; Kraus, S.; Jörißen, H.; Fischer, R.; Stein, C.; Nähring, J.; Barth, S.; Püttmann, C.
Journal Article
2014Comparative evaluation of heterologous production systems for recombinant pulmonary surfactant protein D
Salgado, D.; Fischer, R.; Schillberg, S.; Twyman, R.M.; Rasche, S.
Journal Article
2014Comparison of plant-based expression platforms for the heterologous production of geraniol
Vasilev, N.; Schmitz, C.; Dong, L.; Ritala, A.; Imseng, N.; Häkkinen, S.T.; Krol, S. van der; Eibl, R.; Oksman-Caldentey, K.-M.; Bouwmeester, H.; Fischer, R.; Schillberg, S.
Journal Article
2014A CSPG4-specific immunotoxin kills rhabdomyosarcoma cells and binds to primary tumor tissues
Brehm, H.; Niesen, J.; Mladenov, R.; Stein, C.; Pardo, A.; Fey, G.; Helfrich, W.; Fischer, R.; Gattenlöhner, S.; Barth, S.
Journal Article
2014Differential inductions of phenylalanine ammonia-lyase and chalcone synthase during wounding, salicylic acid treatment, and salinity stress in safflower, Carthamus tinctorius
Dehghan, S.; Sadeghi, M.; Pöppel, A.; Fischer, R.; Lakes-Harlan, R.; Kavousi, H.R.; Vilcinskas, A.; Rahnamaeian, M.
Journal Article
2014Downstream processing of biopharmaceutical proteins produced in plants: The pros and cons of flocculants
Buyel, J.F.; Fischer, R.
Journal Article
2014EpCAM-Selective Elimination of Carcinoma Cells by a Novel MAP-Based Cytolytic Fusion Protein
Hristodorov, D.; Amoury, M.; Mladenov, R.; Niesen, J.; Arens, K.; Berges, N.; Hein, L.; Fiore, S. di; Pham, A.T.; Huhn, M.; Helfrich, W.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2014Expression of Recombinant Cellulase Cel5A from Trichoderma reesei in Tobacco Plants
Garvey, M.; Klinger, J.; Klose, H.; Fischer, R.; Commandeur, U.
Journal Article, Non Book Material
2014Flexible metal–organic frameworks
Schneemann, Andreas; Bon, Volodymyr; Schwedler, Inke; Senkovska, Irena; Kaskel, Stefan; Fischer, Roland A.
Journal Article
2014Flocculation increases the efficacy of depth filtration during the downstream processing of recombinant pharmaceutical proteins produced in tobacco
Buyel, J.F.; Fischer, R.
Journal Article
2014Generic chromatography-based purification strategies accelerate the development of downstream processes for biopharmaceutical proteins produced in plants
Buyel, J.F.; Fischer, R.
Journal Article
2014Glucose oxidase variants with improved properities
Fischer, Rainer; Ostafe, Raluca; Prodanovic, Radivoje
Patent
2014A high-throughput cellulase screening system based on droplet microfluidics
Ostafe, R.; Prodanovic, R.; Ung, WL.; Weitz, DA.; Fischer, R.
Journal Article
2014Human microtubule-associated protein tau mediates targeted killing of CD30+ lymphoma cells in vitro and inhibits tumour growth in vivo
Hristodorov, D.; Nordlohne, J.; Mladenov, R.; Huhn, M.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2014Image-based analysis of cell-specific productivity for plant cell suspension cultures
Havenith, H.; Raven, N.; Fiore, S. di; Fischer, R.; Schillberg, S.
Journal Article
2014In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells
Niesen, J.; Brehm, H.; Stein, C.; Berges, N.; Pardo, A.; Fischer, R.; Haaf, A. ten; Gattenlöhner, S.; Tur, M.K.; Barth, S.
Journal Article
2014Inhibition of protease activity by antisense RNA improves recombinant protein production in Nicotiana tabacum cv. Bright Yellow 2 (BY-2) suspension cells
Mandal, Manoj K.; Fischer, Rainer; Schillberg, Stefan; Schiermeyer, Andreas
Journal Article
2014Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission
Kern, S.; Agarwal, S.; Huber, K.; Gehring, A.P.; Strödke, B.; Wirth, C.C.; Brügl, T.; Abodo, L.O.; Dandekar, T.; Doerig, C.; Fischer, R.; Tobin, A.B.; Alam, M.M.; Bracher, F.; Pradel, G.
Journal Article
2014Lean Management - Worthülse oder Erfolgskonzept?. Bd.2: Maschinenbau
Maas, Steffen; Weidner, Jörg; Fischer, Roland
Study
2014Malaria vaccine candidate antigen targeting the pre-erythrocytic stage of Plasmodium falciparum produced at high level in plants
Voepel, N.; Boes, A.; Edgue, G.; Beiss, V.; Kapelski, S.; Reimann, A.; Schillberg, S.; Pradel, G.; Fendel, R.; Scheuermayer, M.; Spiegel, H.; Fischer, R.
Journal Article
2014Metabolic engineering for p-coumaryl alcohol production in Escherichia coli by introducing an artificial phenylpropanoid pathway
Jansen, F.; Gillessen, B.; Mueller, F.; Commandeur, U.; Fischer, R.; Kreuzaler, F.
Journal Article
2014Molecular Farming in Plants. The Long Road to the Market
Fischer, R.; Buyel, J.F.; Schillberg, S.; Twyman, R.M.
Book Article
2014Molecular Farming: Innovative Produktion pharmazeutischer Proteine in Pflanzen
Buyel, J.F.; Reimann, A.; Drossard, J.; Fischer, R.
Journal Article
2014Novel pest control methods
Vilcinskas, Andreas; Fischer, Rainer; Will, Torsten
Patent
2014Novel vaccines against apicomplexan pathoges
Boes, Alexander; Edgü, Güven; Beiß, Véronique; Sack, Markus; Reimann, Andreas; Fischer, Rainer
Patent
2014Eine offene Telemetrieplattform für implantierbare Medizintechnik
Wallrodt, M.; Harnack, M.; Görtz, Michael; Fischer, R.; Mokwa, Wilfried; Biela, S.; Pfennig, M.; Schmitz-Rode, Thomas
Journal Article
2014The p38-mediated rapid down-regulation of cell surface gp130 expression impairs interleukin-6 signaling in the synovial fluid of juvenile idiopathic arthritis patients
Honke, N.; Ohl, K.; Wiener, A.; Bierwagen, J.; Peitz, J.; Fiore, S. di; Fischer, R.; Wagner, N.; Wüller, S.; Tenbrock, K.
Journal Article
2014Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes
Wirth, C.C.; Glushakova, S.; Scheuermayer, M.; Repnik, U.; Garg, S.; Schaack, D.; Kachman, M.M.; Weißbach, T.; Zimmerberg, J.; Dandekar, T.; Griffiths, G.; Chitnis, C.E.; Singh, S.; Fischer, R.; Pradel, G.
Journal Article
2014pH-dependent nano-capturing of tartaric acid using dendrimers
Schramm, O.G.; López-Cortés, X.; Santos, L.S.; Laurie, V.F.; González Nilo, F.D.; Krolik, M.; Fischer, R.; Fiore, S. di
Journal Article
2014Plant molecular pharming for the treatment of chronic and infectious diseases
Stoger, E.; Fischer, R.; Moloney, M.; Ma, J.K.C.
Book Article
2014Potato virus X-based expression vectors are stabilized for long-term production of proteins and larger inserts
Dickmeis, C.; Fischer, R.; Commandeur, U.
Journal Article
2014Rational design of a host cell protein heat precipitation step simplifies the subsequent purification of recombinant proteins from tobacco
Buyel, J.F.; Gruchow, H.M.; Boes, A.; Fischer, R.
Journal Article
2014Scale-down models to optimize a filter train for the downstream purification of recombinant pharmaceutical proteins produced in tobacco leaves
Buyel, J.F.; Fischer, R.
Journal Article
2014A sensitive monitoring system for mammalian cell cultivation processes: A PAT approach
Winckler, S.; Krueger, R.; Schnitzler, T.; Zang, W.; Fischer, R.; Biselli, M.
Journal Article
2014Species-specific considerations in using the fish embryo test as analternative to identify endocrine disruption
Schiller, Viktoria; Zhang, Xiaowei; Hecker, Markus; Schäfers, Christoph; Fischer, Rainer; Fenske, Martina
Journal Article
2014Ultra-high-throughput screening method for the directed evolution of glucose oxidase
Ostafe, R.; Prodanovic, R.; Nazor, J.; Fischer, R.
Journal Article
201316S rRNA Gene-Based Identification of Elizabethkingia meningoseptica (Flavobacteriales: Flavobacteriaceae) as a Dominant Midgut Bacterium of the Asian Malaria Vector Anopheles stephensi (Dipteria: Culicidae) With Antimicrobial Activities
Ngwa, C.J.; Glöckner, V.; Abdelmohsen, U.; Scheuermayer, M.; Fischer, R.; Hentschel, U.; Pradel, G.
Journal Article
2013Brain infection and activation of neuronal repair mechanisms by the human pathogen Listeria monocytogenes in the lepidopteran model host Galleria mellonella
Mukherjee, K.; Hain, T.; Fischer, R.; Chakraborty, T.; Vilcinskas, A.
Journal Article
2013Cellulases for biomass degradation: Comparing recombinant cellulase expression platforms
Garvey, M.; Klose, H.; Fischer, R.; Lambertz, C.; Commandeur, U.
Journal Article
2013Cellulases from insects
Fischer, R.; Ostafe, R.; Twyman, R.M.
Book Article
2013Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito
Ngwa, C.J.; Scheuermayer, M.; Mair, G.R.; Kern, S.; Brügl, T.; Wirth, C.C.; Aminake, M.N.; Wiesner, J.; Fischer, R.; Vilcinskas, A.; Pradel, G.
Journal Article
2013Characterization and dynamic behavior of wild yeast during spontaneous wine fermentation in steel tanks and amphorae
Diaz, Cecilia; Molina, A.M.; Nähring, Jörg; Fischer, Rainer
Journal Article
2013Characterization of selected organic and mineral components of qvevri wines
Diaz, C.; Laurie, V.F.; Molina, A.M.; Bücking, M.; Fischer, R.
Journal Article
2013Cloning, Heterologous Expression, Purification and Characterization of M12 Mutant of Aspergillus niger Glucose Oxidase in Yeast Pichia pastoris KM71H
Kovačević, G.; Blažić, M.; Draganić, B; Ostafe, R.; Gavrović-Jankulović, M.; Fischer, R.; Prodanović, R.
Journal Article
2013Commercial aspects of pharmaceutical protein production in plants
Fischer, R.; Schillberg, S.; Buyel, J.F.; Twyman, R.M.
Journal Article
2013Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model
Schiffer, S.; Hansen, H.P.; Hehmann-Titt, G.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2013An efficient process for the saccharification of wood chips by combined ionic liquid pretreatment and enzymatic hydrolysis
Viell, J.; Wulfhorst, H.; Schmidt, T.; Commandeur, U.; Fischer, R.; Spiess, A.; Marquardt, W.
Journal Article
2013Ethanol inducible expression of a mesophilic cellulase avoids adverse effects on plant development
Klose, H.; Günl, M.; Usadel, B.; Fischer, R.; Commandeur, U.
Journal Article
2013Flow cytometry-based ultra-high-throughput screening assay for cellulase activity
Ostafe, R.; Prodanovic, R.; Commandeur, U.; Fischer, R.
Journal Article
2013Galleria Mellonella as a model host to study gut microbe homeostasis and brain infection by the human pathogen Listeria Monocytogenes
Mukherjee, K.; Raju, R.; Fischer, R.; Vilcinskas, A.
Book Article
2013Generation and comparative characterization of glycosylated and aglycosylated human IgG1 antibodies
Hristodorov, Dmitrij; Fischer, Rainer; Joerissen, Hannah; Müller-Tiemann, Beate; Apeler, Heiner; Linden, Lars
Journal Article
2013Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells
Schiffer, S.; Letzian, S.; Jost, E.; Mladenov, R.; Hristodorov, D.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2013The impact of complement evasion on transmission of malaria
Pradel, G.; Simon, N.; Lasonder, E.; Scheuermayer, M.; Kühn, A.; Fischer, R.; Zipfel, P.; Skerka, C.
Journal Article
2013Isolation and characterization of isochorismate synthase and cinnamate 4-hydroxylase during salinity stress, wounding, and salicylic acid treatment in Carthamus tinctorius
Sadeghi, M.; Dehghan, S.; Fischer, R.; Wenzel, U.; Vilcinskas, A.; Kavousi, H.R.; Rahnamaeian, M.
Journal Article
2013Malaria Parasites Co-opt Human Factor H to Prevent Complement-Mediated Lysis in the Mosquito Midgut
Simon, N.; Lasonder, E.; Scheuermayer, M.; Kuehn, A.; Tews, S.; Fischer, R.; Zipfel, P.; Skerka, C.; Pradel, G.
Journal Article
2013Mehr Ah am Bau
Fischer, Roland; Hölczli, Andreas
Journal Article
2013Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo
Hristodorov, D.; Mladenov, R.; Pardo, A.; Pham, A.-T.; Huhn, M.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2013Molecular farming of pharmaceutical proteins using plant suspension cell and tissue cultures
Schillberg, S.; Raven, N.; Fischer, R.; Twyman, R.M.; Schiermeyer, A.
Journal Article
2013A monoclonal antibody for the detection of SNAP/CLIP-tagged proteins
Puettmann, C.; Kolberg, K.; Hagen, S.; Schmies, S.; Fischer, R.; Naehring, J.; Barth, S.
Journal Article
2013Optimization of BY-2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method
Vasilev, N.; Grömping, U.; Lipperts, A.; Raven, N.; Fischer, R.; Schillberg, S.
Journal Article
2013Optimizing the yield of recombinant pharmaceutical proteins in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Journal Article
2013The PAPR problem in OFDM transmission: New directions for a long-lasting problem
Wunder, G.; Fischer, R.F.H.; Boche, H.; Litsyn, S.; No, J.-S.
Journal Article
2013Plant-based production of recombinant plasmodium surface protein Pf38 and evaluation of its potential as a vaccine candidate
Feller, Tanja; Thom, Pascal; Koch, Natalie; Spiegel, Holger; Addai-Mensah, Otchere; Fischer, Rainer; Reimann, Andreas; Pradel, Gabriele; Fendel, Rolf; Schillberg, Stefan; Scheuermayer, Matthias; Schinkel, Helga
Journal Article
2013Predictive models for the accumulation of a fluorescent marker protein in tobacco leaves according to the promoter/5' UTR combination
Buyel, J.F.; Kaever, T.; Buyel, J.J.; Fischer, Rainer
Journal Article
2013Processing heterogeneous biomass: Overcoming the hurdles in model building
Buyel, J.F.; Fischer, R.
Journal Article
2013Processo de Produção de Pterocarpanos, composição Citomuduladora Compreendendo Pterocarpanos, e uso de Pterocarpanos
Fischer, Rainer; Fiore, Stefano di; Ó Pessoa, Claudia do; Araújo Barros Nepomuceno, Francisco Washington; Damasceno Rocha, Danilo
Patent
2013Protective oral vaccination against Infectious bursal disease virus using the major viral antigenic protein VP2 produced in Pichia pastoris
Taghavian, O.; Spiegel, H.; Hauck, R.; Hafez, H.M.; Fischer, R.; Schillberg, S.
Journal Article
2013Species-Dependent Functionality of the Human Cytolytic Fusion Proteins Granzyme B-H22(scFv) and H22(scFv)-Angiogenin in Macrophages
Schiffer, S.; Hristodorov, D.; Mladenov, R.; Aslanian, E.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2013Transcriptome alterations in zebrafish embryos after exposure to environmental estrogens and anti-androgens can reveal endocrine disruption
Schiller, V.; Wichmann, A.; Kriehuber, R.; Schäfers, C.; Fischer, R.; Fenske, M.
Journal Article
2013The use of quantitative structure-activity relationship models to develop optimized processes for the removal of tobacco host cell proteins during biopharmaceutical production
Buyel, J.F.; Woo, J.A.; Cramer, S.M.; Fischer, R.
Journal Article
2013With or without sugar? (A)glycosylation of therapeutic antibodies
Hristodorov, D.; Fischer, R.; Linden, L.
Journal Article
2013Yeast surface display for the expression, purification and characterization of wild-type and B11 mutant glucose oxidases
Blazic, M.; Kovacevic, G.; Prodanovic, O.; Ostafe, R.; Gavrovic-Jankulovic, M.; Fischer, R.; Prodanovic, R.
Journal Article
2012Artifizielle Forisomenkörper mit SEO-F-Fusionsproteinen, pflanzliche oder Hefezellen mit Vektoren, die für diese Proteine codieren, sowie Vektoren, die für SEO-F-Fusionsproteine codieren
Müller, Boje; Prüfer, Dirk; Fischer, R.
Patent
2012Changes in the transcriptome of the malaria parasite Plasmodium falciparum during its transmission from the human to the mosquito
Ngwa, C.J.; Scheuermayer, M.; Wiesner, J.; Fischer, R.; Vilcinskas, A.; Pradel, G.
Conference Paper, Journal Article
2012Extraction, purification and characterization of the plant-produced HPV16 subunit vaccine candidate E7 GGG
Buyel, J.F.; Bautista, J.A.; Fischer, R.; Yusibov, V.M.
Journal Article
2012GMP issues for recombinant plant-derived pharmaceutical proteins
Fischer, R.; Schillberg, S.; Hellwig, S.; Twyman, R.M.; Drossard, J.
Journal Article
2012Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity
Röhrich, C.R.; Ngwa, C.J.; Wiesner, J.; Schmidtberg, H.; Degenkolb, T.; Kollewe, C.; Fischer, R.; Pradel, G.; Vilcinskas, A.
Journal Article
2012Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection
Mukherjee, K.; Fischer, R.; Vilcinskas, A.
Journal Article
2012Hyperthermophilic endoglucanase for in planta lignocellulose conversion
Klose, H.; Röder, J.; Girfoglio, M.; Fischer, R.; Commandeur, U.
Journal Article
2012In vivo expression and binding activity of scFv-RWAV, which recognizes the coat protein of tomato leaf curl New Delhi virus (family Geminiviridae)
Zakri, A.M.; Ziegler, A.; Commandeur, U.; Fischer, R.; Torrance, L.
Journal Article
2012In vivo imaging of immunotoxin treatment using Katushka-transfected A-431 cells in a murine xenograft tumour model
Pardo, A.; Stöcker, M.; Kampmeier, F.; Melmer, G.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2012Kühlkettenüberwachung für Prepreg-Materialien
Philipp, T.R.; Stockenberger, D.; Fischer, R.; Günthner, W.A.; Reinhart, G.
Journal Article
2012Method for the generation of a monoclonal plant cell line
Kirchhoff, Janina; Schillberg, Stefan; Schiermeyer, Andreas; Schinkel, Helga; Fischer, Rainer
Patent
2012Monoclonal tobacco cell lines with enhanced recombinant protein yields can be generated from heterogeneous cell suspension cultures by flow sorting
Kirchhoff, Janina; Raven, Nicole; Boes, Alexander; Roberts, Jean L.; Russell, Sean; Treffenfeldt, Wiltrud; Fischer, Rainer; Schinkel, Helga; Schiermeyer, Andreas; Schillberg, Stefan
Journal Article
2012Nucleic acid sequences and peptides/proteins of the FT family providing flower-repressing properties in tobacco and transgenic plants transformed therewith
Harig, Lena; Prüfer, Dirk; Fischer, R.
Patent
2012A potential nanobiotechnology platform based on infectious bursal disease subviral particles
Taghavian, Omid; Mandal, Manoj K.; Steinmetz, Nicole F.; Rasche, Stefan; Spiegel, Holger; Fischer, Rainer; Schillberg, Stefan
Journal Article
2012Predictive models for transient protein expression in tobacco (Nicotiana tabacum L.) can optimize process time, yield, and downstream costs
Buyel, J.F.; Fischer, R.
Journal Article
2012The production of vaccines and therapeutic antibodies in plants
Twyman, Richard M.; Schillberg, S.; Fischer, R.
Book Article
2012Proteins from the FLOWERING LOCUS T-like subclade of the PEBP family act antagonistically to regulate floral initiation in tobacco
Harig, Lena; Beinecke, Farina A.; Oltmanns, Jens; Muth, Jost; Mülle, Oliver; Rüping, Boris; Twyman, Richard M.; Fischer, Rainer; Prüfer, Dirk; Noll, Gundula A.
Journal Article
2012Proteomic analysis of latex from the rubber-producing plant Taraxacum brevicorniculatum
Wahler, D.; Colby, T.; Kowalski, N.A.; Harzen, A.; Wotzka, S.Y.; Hillebrand, A.; Fischer, R.; Helsper, J.; Schmidt, J.; Schulze Gronover, C.; Prüfer, D.
Journal Article
2011Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco
Boes, A.; Spiegel, H.; Delbrück, H.; Fischer, R.; Schillberg, S.; Sack, M.
Journal Article
2011Expression and in vito characterisation of human Granzyme B-based immunotherapeutics for specific targeting of CD64 1hn+ malignancies
Stahnke, B.
: Fischer, R. (Prüfer)
Dissertation
2011Expression of HCV glycoprotein E1 and its evaluation for vaccine development
Abdel-Mageed, W.S.el-S.
: Fischer, R. (Prüfer)
Dissertation
2011From recombinant proteins to plant-made-pharmaceuticals
Stoger, E.; Rademacher, T.; Arcalis, E.; Sack, M.; Stiegler, G.; Altmann, F.; Fischer, R.
Journal Article
2011Generierung und chararktersierung eines immunoaffinitätsbasierten Reinigungssystems für rekombinante Proteine
Rasche, S.
: Fischer, R. (Prüfer)
Dissertation
2011GMP und Auftragsherstellung - Der weg zu klinischen biopharmazeutischen Prüfarzneimitteln
Mertens, H.; Melmer, G.; Fischer, R.
Journal Article
2011High level recombinant antibody production in Chinese hamster ovary (CHO) cells and characterisation of the carcinoembryonic antigen (CEA) specific human full-size IgG1 H10
Peuscher, A.V.
: Fischer, R. (Prüfer)
Dissertation
2011How recombinant swollenin from Kluyveromyces lactis affects cellulosic substrates and accelerates their hydrolysis
Jäger, G.; Girfoglio, M.; Dollo, F.; Rinaldi, R.; Bongard, H.; Commandeur, U.; Fischer, R.; Spiess, A.C.; Büchs, J.
Journal Article
2011Influence of sodium bromide on the thermal decomposition of tetraphenylphosphonium montmorillonite
Birkenstock, J.; Kleemeier, M.; Vogt, C.; Wendschuh, M.; Hartwig, A.; Fischer, R.X.
Journal Article
2011Layered silicate epoxy nanocomposites: formation of the inorganic-carbonaceous fire protection layer
Schartel, B.; Weiss, A.; Sturm, H.; Kleemeier, M.; Hartwig, A.; Vogt, C.; Fischer, R.X.
Journal Article
2011MOF processing by electrospinning for functional textiles
Rose, Marcus; Böhringer, Bertram; Jolly, Marc; Fischer, Roland A.; Kaskel, Stefan
Journal Article
2011One-step protein purification: Use of a novel epitope tag for highly efficient detection and purification of recombinant proteins
Rasche, S.; Martin, A.; Holzem, A.; Fischer, R.; Schinkel, H.; Schillberg, S.
Journal Article
2011Produktion und Evaluierung von oral applizierbaren Impfstoffen aus Pflanzen
Hehmann-Titt, G.
: Fischer, R. (Prüfer)
Dissertation
2011Purification methods in biomanufacturing: Existing techniques must be revamped in order to deliver as much product as possible
Fischer, R.
Journal Article
2010Biochemical properties of the matrix metalloproteinase NtMMP1 from Nicotiana tabacum cv. BY-2 suspension cells
Mandal, M.K.; Fischer, R.; Schillberg, S.; Schiermeyer, A.
Journal Article
2010The changing fate of a secretory glycoprotein in developing maize endosperm
Arcalis, E.; Stadlmann, J.; Marcel, S.; Drakakaki, G.; Winter, V.; Rodriguez, J.; Fischer, R.; Altmann, F.; Stoger, E.
Journal Article
2010Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz
Schmidt, T.; Lenders, M.; Hillebrand, A.; Deenen, N. van; Munt, O.; Reichelt, R.; Eisenreich, W.; Fischer, R.; Prüfer, D.; Schulze Gronover, C.
Journal Article
2010Evaluation of NbN thin films grown by MOCVD and plasma-enhanced ALD for gate electrode application in high-k/SiO2 gate stacks
Hinz, J.; Bauer, A.J.; Thiede, T.; Fischer, R.A.; Frey, L.
Journal Article
2010Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2009/2010
: Fischer, R.
Annual Report
2010Generation and characterization of a scFv against recombinant coat protein of the geminivirus tomato leaf curl New Delhi virus
Zakri, A.M.; Ziegler, A.; Torrance, L.; Fischer, R.; Commandeur, U.
Journal Article
2010Genetic determinants of Pseudomonas aeruginosa biofilm establishment
Musken, M.; Fiore, S. di; Dotsch, A.; Fischer, R.; Häussler, S.
Journal Article
2010Immunogenic properties of chimeric potato virus X particles displaying the hepatitis C virus hypervariable region I peptide R9
Uhde-Holzem, K.; Schlösser, V.; Viazov, S.; Fischer, R.; Commandeur, U.
Journal Article
2010Independent information of nonspecific biomarkers in exhaled breath condensate
Dressel, H.; Müller, F.; Fischer, R.; Römmelt, H.; Hohlfeld, J.M.; Behr, J.; Huber, R.M.; Nowak, D.; Jörres, R.A.
Journal Article
2010A monoclonal antibody that specifically binds chitosan in vitro and in situ on fungal cell walls
Schubert, M.; Agdour, S.; Fischer, R.; Olbrich, Y.; Schinkel, H.; Schillberg, S.
Journal Article
2010Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture
Holland, T.; Sack, M.; Rademacher, T.; Schmale, K.; Altmann, F.; Stadlmann, J.; Fischer, R.; Hellwig, S.
Journal Article
2010Potato virus X as a novel platform for potential biomedical applications
Steinmetz, N.F.; Miertens, M.E.; Taurog, R.E.; Johnson, J.E.; Commandeur, U.; Fischer, R.; Manchester, M.
Journal Article
2010Rapid optical imaging of EGF receptor expression with a single-chain antibody SNAP-tag fusion protein
Kampmeier, F.; Niesen, J.; Koers, A.; Ribbert, M.; Brecht, A.; Fischer, R.; Kießling, F.; Barth, S.; Thepen, T.
Journal Article
2010Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody
Sainsbury, F.; Sack, M.; Stadlmann, J.; Quendler, H.; Fischer, R.; Lomonossoff, G.P.
Journal Article
2010Recombinant, ETA'-based CD64 immunotoxins: Improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice
Ribbert, T.; Thepen, T.; Tur, M.K.; Fischer, R.; Huhn, M.; Barth, S.
Journal Article
2010Salt-assisted organic-acid-catalyzed depolymerization of cellulose
Stein, T. vom; Grande, P.; Sibilla, F.; Commandeur, U.; Fischer, R.; Leitner, W.; Domínguez de María, P.
Journal Article
2009An assay for the detection of grapevine leafroll-associated virus 3 using a single-chain fragment variable antibody
Cogotzi, L.; Giampetruzzi, A.; Nölke, G.; Orecchia, M.; Elicio, V.; Castellano, M.A.; Martelli, G.P.; Fischer, R.; Schillberg, S.; Saldarelli, P.
Journal Article
2009Assessing potential for movement of active substances and their metabolites to ground water in the EU
Boesten, J.J.T.I.; Fischer, R.; Gottesbüren, B.; Hanze, K.; Huber, A.; Jarvis, T.; Jones, R.L.; Klein, Michael; Pokludová, M.; Remy, B.; Sweeney, P.; Tiktak, A.; Trevisan, M.; Vanclooster, M.; Vanderborght, J.
Report
2009Deposition of niobium nitride thin films from Tert-Butylamido-Tris-(Diethylamido)-Niobium by a modified industrial MOCVD reactor
Thiede, T.B.; Parala, H.; Reuter, K.; Passing, G.; Kirchmeyer, S.; Hinz, J.; Lemberger, M.; Bauer, A.J.; Barreca, D.; Gasparotto, A.; Fischer, R.A.
Journal Article
2009Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology
Loesing, J.-B.; Fiore, S. di; Ritter, K.; Fischer, R.; Kleines, M.
Journal Article
2009Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2008
: Fischer, R.; Kördel, W.
Annual Report
2009Grapevine fanleaf virus (GFLV)-specific antibodies confer GFLV and Arabis mosaic virus (ArMV) resistance in Nicotiana benthamiana
Nölke, G.; Cobanov, P.; Uhde-Holzem, K.; Reustle, G.; Fischer, R.; Schillberg, S.
Journal Article
2009Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody
Floss, D.M.; Sack, M.; Arcalis, E.; Stadlmann, J.; Quendler, H.; Rademacher, T.; Stoger, E.; Scheller, J.; Fischer, R.; Conrad, U.
Journal Article
2009Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa
Scholz, M.; Lipinski, M.; Leupold, M.; Luftmann, H.; Harig, L.; Ofir, R.; Fischer, R.; Prüfer, D.; Müller, K.J.
Journal Article
2009Molecular farming of antibodies in plants
Fischer, R.; Schillberg, S.; Twyman, R.M.
Book Article
2009Molecular farming of human tissue transglutaminase in tobacco plants
Sorrentino, A.; Schillberg, S.; Fischer, R.; Porta, R.; Mariniello, L.
Journal Article
2009Polyphenoloxidase silencing affects latex coagulation in taraxacum species
Wahler, D.; Schulze Gronover, C.; Richter, C.; Foucu, F.; Twyman, R.M.; Moerschbacher, B.M.; Fischer, R.; Muth, J.; Prüfer, D.
Journal Article
2009The promoters of forisome genes MtSEO2 and MtSEO3 direct gene expression to immature sieve elements in Medicago truncatula and Nicotiana tabacum
Noll, G.A.; Rüping, B.; Ernst, A.M.; Bucsenez, M.; Twyman, R.M.; Fischer, R.; Prüfer, D.
Journal Article
2009Recombinant bispecific single chain antibody fragments induce Fc gamma-receptor-mediated elimination of CD30(+) lymphoma cells
Ranft, K.; Thepen, T.; Fischer, R.; Barth, S.; Stöcker, M.
Journal Article
2009A squalene epoxidase from Nigella sativa participates in saponin biosynthesis and mediates terbinafine resistance in yeast
Lipinski, M.; Scholz, M.; Pieper, K.; Fischer, R.; Prüfer, D.; Müller, K.J.
Journal Article
2009The structure of the dizinc subclass B2 Metallo-beta-Lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site
Bebrone, C.; Delbrück, H.; Kupper, M.B.; Schlömer, P.; Willmann, C.; Frere, J.-M.; Fischer, R.; Galleni, M.; Hoffmann, K.M.V.
Journal Article
2008Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants
Floss, D.M.; Sack, M.; Stadlmann, J.; Rademacher, T.; Scheller, J.; Stöger, E.; Fischer, R.; Conrad, U.
Journal Article
2008Depletion of autoreactive B-lymphocytes by a recombinant myelin oligodendrocyte glycoprotein-based immunotoxin
Nachreiner, T.; Kampmeier, F.; Thepen, T.; Fischer, R.; Barth, S.; Stocker, M.
Journal Article
2008Engineering Fusarium head blight resistance in wheat by expression of a fusion protein containing a Fusarium-specific antibody and an antifungal peptide
Li, H.-P.; Bo Zhang, J.; Shi, R.P.; Huang, T.; Fischer, R.; Liao, Y.C.
Journal Article
2008Eukaryotic expression and secretion of EGFP-labeled annexin A5
Stöcker, M.; Pardo, A.; Hetzel, C.; Reutelingsperger, C.; Fischer, R.; Barth, S.
Journal Article
2008Evaluation of MOCVD grown niobium nitride films as gate electrode for advanced CMOS technology
Thiede, T.; Parala, H.; Reuter, K.; Passing, G.; Kirchmeyer, S.; Hinz, J.; Lemberger, M.; Bauer, A.J.; Fischer, R.A.
Conference Paper
2008Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants
Spök, A.; Twyman, R.M.; Fischer, R.; Ma, J.K.-C.; Sparrow, P.A.C.
Journal Article
2008Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2007
: Fischer, R.; Kördel, W.
Annual Report
2008Generation and characterization of a recombinant antibody fragment that binds to the coat protein of grapevine leafroll-associated virus 3
Orecchia, M.; Nölke, G.; Saldarelli, P.; Dell´Orco, M.; Uhde-Holzem, K.; Sack, M.; Martelli, G.; Fischer, R.; Schillberg, S.
Journal Article
2008Generation and evaluation of movement protein-specific single-chain antibodies for delaying symptoms of Tomato spotted wilt virus infection in tobacco
Zhang, M.Y.; Zimmermann, S.; Fischer, R.; Schillberg, S.
Journal Article
2008Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes
Stahnke, B.; Thepen, T.; Stöcker, M.; Rosinke, R.; Jost, E.; Fischer, R.; Tur, M.K.; Barth, S.
Journal Article
2008Modulation of polyamine biosynthesis in transformed tobacco plants by targeting ornithine decarboxylase to an atypical subcellular compartment
Nölke, G.; Schneider, B.; Agdour, S.; Drossard, J.; Fischer, R.; Schillberg, S.
Journal Article
2008New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants
Platis, D.; Drossard, J.; Fischer, R.; Ma, J.K.-C.; Labrou, N.E.
Journal Article
2008Phage-display derived single-chain fragment variable (scFv) antibodies recognizing conformational epitopes of Escherichia coli heat-labile enterotoxin B-subunit
Chung, W.Y.; Sack, M.; Carter, R.; Spiegel, H.; Fischer, R.; Hirst, T.R.; Williams, N.A.; James, R.F.L.
Journal Article
2008Plantibody-mediated inhibition of the potato leafroll virus P1 protein reduces virus accumulation
Nickel, H.; Kawchuk, L.; Twyman, R.M.; Zimmermann, S.; Junghans, H.; Winter, S.; Fischer, R.; Prüfer, D.
Journal Article
2008Small cleavable adapters enhance the specific cytotoxicity of a humanized immunotoxin directed against CD64-positive cells
Hetzel, C.; Bachran, C.; Fischer, R.; Fuchs, H.; Barth, S.; Stocker, M.
Journal Article
2007Design of protein-membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V
Segers, K.; Sperandio, O.; Sack, M.; Fischer, R.; Miteva, M.A.; Rosing, J.; Nicolaes, G.A.F.; Villoutreix, B.O.
Journal Article
2007Facing the future with pharmaceuticals from plants
Fischer, R.; Twyman, R.M.; Hellwig, S.; Drossard, J.; Schillberg, S.
Conference Paper
2007Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2006
: Fischer, R.; Schäffer, A.
Annual Report
2007Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures
Sack, M.; Paetz, A.; Kunert, R.; Bomble, M.; Hesse, F.; Stiegler, G.; Fischer, R.; Katinger, H.; Stöger, E.; Rademacher, T.
Journal Article
2007Genetic stability of recombinant potato virus X virus vectors presenting foreign epitopes
Uhde-Holzem, K.; Fischer, R.; Commandeur, U.
Journal Article
2007Immunodetection of Venturia inaequalis ascospores with phage antibodies
Ribbert, M.; Wolters, A.; Barth, S.; Stöcker, M.; Schaeffer, A.; Fischer, R.; Finnern, R.
Journal Article
2007MOCVD of TaN Using the All-Nitrogen-Coordinated Precursors [Ta(NEtMe)3(N-tBu)], [Ta(NEtMe)(N-tBu){C(N-iPr)2(NEtMe)}2] and [Ta(NMeEt)2(N-tBu){Me2N-N(SiMe3)}]
Baunemann, A.; Lemberger, M.; Bauer, A.J.; Parala, H.; Fischer, R.A.
Journal Article
2007MOCVD of tantalum nitride thin films from TBTEMT single source precursor as metal electrodes in CMOS applications
Lemberger, M.; Thiemann, S.; Baunemann, A.; Parala, H.; Fischer, R.A.; Hinz, J.; Bauer, A.J.; Ryssel, H.
Conference Paper, Journal Article
2007Molecular farming of antibodies in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Book Article
2007Nichtlineares Vorcodierungsverfahren fuer einen digitalen Broadcastkanal
Fischer, R.; Windpassinger, C.
Patent
2007Opportunities and challenges for production of recombinant pharmaceuticals in plant expression systems
Fischer, R.
Conference Paper
2007Optimization of human papillomavirus type 16 (HPV-16) L1 expression in plants
MacIean, J.; Koekemoer, M.; Oliver, A.J.; Stewart, D.; Hitzeroth, I.I.; Rademacher, T.; Fischer, R.; Williamson, A.-L.; Rybicki, E.P.
Journal Article
2007Production of therapeutic antibodies in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Book Article
2007Spatial and temporal regulation of the forisome gene for1 in the phloem during plant development
Noll, G.A.; Fontanellaz, M.E.; Rüping, B.; Ashoub, A.; Bel, A.J.E. van; Fischer, R.; Knoblauch, M.; Prüfer, D.
Journal Article
2007Tomato protein of the resistance gene Ve2 to verticillium wilt [Verticillium spp.] is located in the endoplasmic reticulum
Ruthardt, N.; Kawchuk, L.M.; Fischer, R.; Emans, N.
Journal Article
2006Antibody-based metabolic engineering in plants
Nölke, G.; Fischer, R.; Schillberg, S.
Journal Article
2006Arabidopsis thaliana wild type, pho1, and pho2 mutant plants show different responses to exogenous cytokinins
Lan, P.; Li, W.; Fischer, R.
Journal Article
2006Constitutive knox1 gene expression in dandelion (Taraxacum officinale, Web.) changes leaf morphology from simple to compound
Müller, K.J.; He, X.; Fischer, R.; Prüfer, D.
Journal Article
2006Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2005
: Fischer, R.; Schäffer, A.
Annual Report
2006How repeated epiphylly correlates with gene expression of resident knox1 in the leaves of tobacco epiphyllous shoots
Müller, K.J.; Lin, J.; Fischer, R.; Prüfer, D.
Journal Article
2006Influence of space flight conditions on phenotypes and function of nephritic immune cells of swordtail fish (Xiphophorus helleri)
Piepenbreier, K.; Renn, J.; Fischer, R.; Goerlich, R.
Journal Article
2006The intracellular fate of a recombinant protein is tissue-dependent
Drakakaki, G.; Marcel, S.; Arcalis, E.; Altmann, F.; Gonzalez-Melendi, P.; Fischer, R.; Christou, P.; Stoger, E.
Journal Article
2006Plantibody-based disease resistance in plants
Zimmermann, S.; Emans, N.; Fischer, R.; Schillberg, S.
Book Article
2006The potential of plant virus vectors for vaccine production
Yusibov, V.; Rabindran, S.; Commandeur, U.; Twyman, R.M.; Fischer, R.
Journal Article
2006Reactions to geovisualization: An experience from a European project
Andrienko, G.; Andrienko, N.; Fischer, R.; Mues, V.; Schuck, A.
Journal Article
2006Towards industrial usefulness - cryo-cell-banking of transgenic BY-2 cell cultures
Schmale, K.; Rademacher, T.; Fischer, R.; Hellwig, S.
Journal Article
2006Zebrafish and medaka as models for bone research including implications regarding space-related
Renn, J.; Winkler, C.; Schartl, M.; Fischer, R.; Goerlich, R.
Journal Article
2005Antigen-specific targeting and elimination of EBV-transformed B cells by allergen toxins
Stöcker, M.; Klockenbring, T.; Huhn, M.; Nachreiner, T.; Wicklein, D.; Petersen, A.; Bauer, R.; Goerlich, R.; Fischer, R.; Barth, S.
Journal Article
2005Biopharmaceutical production in cultured cells
Schillberg, S.; Twyman, R.M.; Fischer, R.
Book Article
2005Chemistry of mixed ligand all nitrogen coordinated Ta, Hf, and W precursors for metal nitride MOCVD
Baunemann, A.; Rische, D.; Kim, Y.; Parala, H.; Bauer, A.J.; Lemberger, M.; Fischer, R.A.
Poster
2005DURCH MOLEKULARES PATHOGENICID VERMITTELTE KRANKHEITSRESISTENZ IN PFLANZEN
Fischer, R.; Schillberg, S.; Naehring, J.; Sack, M.; Monecke, M.; Liao, Y.; Spiegel, H.; Zimmerman, S.; Emans, N.; Holzem, A.
Patent
2005Endosperm-specific co-expression of recombinant soybean ferritin and aspergillus phytase in maize results in significant increases in the levels of bioavailable iron
Drakakaki, G.; Marcel, S.; Glahn, R.P.; Lund, E.K.; Pariagh, S.; Fischer, R.; Christou, P.; Stoger, E.
Journal Article
2005Expression of multiple foreign epitopes presented as synthetic antigens on the surface of Potato virus X particles
Uhde, K.; Fischer, R.; Commandeur, U.
Journal Article
2005Four-dimensional imaging of transvacuolar strand dynamics in tobacco BY-2 cells
Ruthardt, N.; Gulde, N.; Spiegel, H.; Fischer, R.; Emans, N.
Journal Article
2005Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2004
: Fischer, R.; Schäffer, A.
Annual Report
2005Generation of human antibody fragments against Streptococcus mutans using a phage display chain shuffling approach
Küpper, M.B.; Huhn, M.; Spiegel, H.; Ma, J.K.-C.; Barth, S.; Fischer, R.; Finnern, R.
Journal Article
2005Immunomodulation of polyamine biosynthesis in tobacco plants has a significant impact on polyamine levels and generates a dwarf phenotype
Nölke, G.; Schneider, B.; Fischer, R.; Schillberg, S.
Journal Article
2005Komplexbildung zur Stabilisierung und Reinigung eines Proteins von Interesse
Sack, M.; Vaquero-Martin, C.; Fischer, R.
Patent
2005MOCVD of conductive cubic HfN thin films from Hf(NR2)4 and N,N-dimethylhydrazine
Kim, Y.; Parala, H.; Bauer, A.J.; Lemberger, M.; Baunemann, A.; Fischer, R.A.
Conference Paper
2005MOCVD of cunductive cubic HfN thin films from Hf(NR2)4 and N,N-dimethylhydrazine
Kim, Y.; Parala, H.; Bauer, A.J.; Lemberger, M.; Baunemann, A.; Fischer, R.A.
Conference Paper
2005Molecular farming for new drugs and vaccines
Ma, J.K.-C.; Barros, E.; Bock, R.; Christou, P.; Dale, P.J.; Dix, P.J.; Fischer, R.; Irwin, J.; Mahoney, R.; Pezzotti, M.; Schillberg, S.; Sparrow, P.; Stoger, E.; Twyman, R.M.
Journal Article
2005Opportunities for recombinant antigen and antibody expression in transgenic plants - technology assessment
Schillberg, S.; Twyman, R.M.; Fischer, R.
Journal Article
2005Plant cells
Fischer, R.; Twyman, R.M.; Drossard, J.; Hellwig, S.; Schillberg, S.
Book Article
2005Plant-derived pharmaceuticals - the road forward
Ma, J.K.-C.; Chikwamba, R.; Sparrow, P.; Fischer, R.; Mahoney, R.; Twyman, R.M.
Journal Article
2005Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells
Schinkel, H.; Schiermeyer, A.; Soeur, R.; Fischer, R.; Schillberg, S.
Journal Article
2005Production of Desmodus rotundus plasminogen activator alpha1 (DSPA alpha1) in tobacco is hampered by proteolysis
Schiermeyer, A.; Schinkel, H.; Apel, S.; Fischer, R.; Schillberg, S.
Journal Article
2005Production of recombinant human serum albumin in transgenic plant suspension cell cultures
Mavituna, M.; Fischer, R.; Schillberg, S.
Abstract
2005Recent progress in plantibody technology
Stoger, E.; Sack, M.; Nicholson, L.; Fischer, R.; Christou, P.
Journal Article
2005Recombinant anti-EGFR immunotoxin 425(scFv)-ETA' demonstrates anti-tumor activity against disseminated human pancreatic cancer in nude mice
Bruell, D.; Bruns, C.J.; Yezhelyev, M.; Huhn, M.; Müller, J.; Ischenko, I.; Decken, V. von der; Fischer, R.; Finnern, R.; Jauch, K.W.; Barth, S.
Journal Article
2005Recombinant bovine uteroglobin at 1.6 angstrom resolution: A preliminary X-ray crystallographic analysis
Decken, V. von der; Delbrück, H.; Herrler, A.; Beier, H.M.; Fischer, R.; Hoffmann, K.M.V.
Journal Article
2005Recombinant human tissue transglutaminase produced into tobacco suspension cell cultures is active and recognizes autoantibodies in the serum of coeliac patients
Sorrentino, A.; Schillberg, S.; Fischer, R.; Rao, R.; Porta, R.; Mariniello, L.
Journal Article
2005A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells
Nicholson, L.; Gonzalez-Melendi, P.; Dolleweerd, C. van; Tuck, H.; Perrin, Y.; Ma, J.K.-C.; Fischer, R.; Christou, P.; Stoger, E.
Journal Article
2005Recombinant soluble human Fc(gamma) receptor I with picomolar affinity for immunoglobulin G
Paetz, A.; Sack, M.; Thepen, T.; Tur, M.K.; Brüll, D.; Finnern, R.; Fischer, R.; Barth, S.
Journal Article
2005Sowing the seeds of success. Pharmaceutical proteins from plants
Stoger, E.; Ma, J.K.-C.; Fischer, R.; Christou, P.
Journal Article
2005Transgenic plants in the biopharmaceutical market
Twyman, R.M.; Schillberg, S.; Fischer, R.
Journal Article
2005Vom Biokatalysator zum Produkt - industrielle Biotechnologie in der Fraunhofer-Gesellschaft
Fischer, R.; Hirth, T.
Book Article
2004Antibody production in transgenic plants
Stoger, E.; Schillberg, S.; Twyman, R.M.; Fischer, R.; Christou, P.
Book Article
2004Antibody-based pathogen resistance in plants
Nölke, G.; Fischer, R.; Schillberg, S.
Journal Article
2004Antigen-specific targeting and elimination of EBV-transformed B cells by allergen-toxins
Klockenbring, T.; Stöcker, M.; Huhn, M.; Petersen, A.; Bauer, R.; Goerlich, R.; Fischer, R.; Barth, S.
Conference Paper
2004Breaking new ground
Lichius, A.; Fiore, S. di; Ruthardt, N.; Jochems, C.; Emans, N.; Fischer, R.
Journal Article
2004Chip-based biosensor technology for the detection of pathogens
Fischer, R.; Ribbert, M.; Finnern, R.; Twyman, R.M.
Conference Paper
2004Engineering and production of recombinant antibodies in plants
Fischer, R.; Commandeur, U.; Schillberg, S.; Twyman, R.M.
Conference Paper
2004Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2003
: Fischer, R.; Schäffer, A.
Annual Report
2004Fusion proteins comprising a Fusarium-specific antibody linked to antifungal peptides protect plants against a fungal pathogen
Peschen, D.; Li, H.-P.; Fischer, R.; Kreuzaler, F.; Liao, Y.C.
Journal Article
2004Glycosylation of recombinant antibody in plants
Sriraman, R.; Sack, M.; Talwar, G.P.; Fischer, R.
Conference Paper
2004Improvement of grapevine using current biotechnology
Fischer, R.; Nölke, G.; Orecchia, M.; Schillberg, S.; Twyman, R.M.
Conference Paper
2004An introduction to industrial and pharmaceutical protein production in plants
Fischer, R.; Emans, N.
Book Article
2004Ion beam polishing for embedded cross-sections and its advantages for FESEM analysis in electronic packaging
Mack, W.; Seidl, B.; Fischer, R.; Ort, T.; Walter, J.; Grünewald, J.; Berthold, L.; Petzold, M.
Conference Paper
2004The long and windy road for proteins: From in vitro to clinical use, and solutions for reducing time to market for protein-based biopharmaceuticals
Fischer, R.
Conference Paper
2004m22(scFv)-ETA', a new recombinant anti-CD64 immunotoxin for specific elimination of AML cells
Tur, M.K.; Huhn, M.; Thepen, T.; Stöcker, M.; Krohn, R.; Vogel, S.; Jost, E.; Osieka, R.; Winkel, J.G. van de; Fischer, R.; Barth, S.
Journal Article
2004Measurement of antibody-membrane interactions by surface plasmon resonance
Klimka, A.; Tur, M.K.; Huhn, M.; Bierfreund, U.; Terrada, E.; Fischer, R.; Finnern, R.; Barth, S.
Journal Article
2004Molecular farming in plants: Technology platforms
Fischer, R.; Emans, N.; Twyman, R.M.; Schillberg, S.
Book Article
2004Molecular farming. Plant-made pharmaceuticals and technical proteins
: Fischer, R.; Schillberg, S.
Book
2004Over-expression and production of plant allergens by molecular farming strategies
Obermeyer, G.; Gehwolf, R.; Sebesta, W.; Hamilton, N.; Gadermaier, G.; Ferreira, F.; Commandeur, U.; Fischer, R.; Bentrup, F.H.
Journal Article
2004Plant cell cultures for the production of recombinant proteins
Hellwig, S.; Drossard, J.; Twyman, R.M.; Fischer, R.
Journal Article
2004Plant-based production of biopharmaceuticals
Fischer, R.; Stoger, E.; Schillberg, S.; Christou, P.; Twyman, R.M.
Journal Article
2004Preliminary x-ray analysis of a human VH fragment at 1.8 Å resolution
Gaur, R.K.; Kupper, M.B.; Fischer, R.; Hoffmann, K.M.V.
Journal Article
2004Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues
Sriraman, R.; Bardor, M.; Sack, M.; Vaquero, C.; Faye, L.; Fischer, R.; Finnern, R.; Lerouge, P.
Journal Article
2004Transient gene expression of recombinant terpenoid indole alkaloid enzymes in Catharanthus roseus leaves
Fiore, S. di; Hoppmann, V.; Fischer, R.; Schillberg, S.
Journal Article
2004Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm
Arcalis, E.; Marcel, S.; Altmann, F.; Kolarich, D.; Drakakaki, G.; Fischer, R.; Christou, P.; Stoger, E.
Journal Article
2004Vesikel mit chimaeren Rezeptoren zur Induktion einer gerichteten T-Zellantwort in vivo
Barth, S.D.; Finnern, R.; Klockenbring, T.; Fischer, R.; Paetz, A.
Patent
2004Viroid-induced RNA silencing of GFP-viroid fusion transgenes does not induce extensive spreading of methylation or transitive silencing
Vogt, U.; Pelissier, T.; Pütz, A.; Razvi, F.; Fischer, R.; Wassenegger, M.
Journal Article
2003'Molecular farming' of antibodies in plants
Schillberg, S.; Fischer, R.; Emans, N.
Journal Article
2003The biosafety of molecular farming in plants
Commandeur, U.; Twyman, R.M.; Fischer, R.
Journal Article
2003Cloning and characterization of a gene coding for a class I chitin synthase from Fusarium graminearum
Li, H.P.; Fu, C.Y.; Peschen, D.; Ling, X.Y.; Fischer, R.; Liao, Y.C.
Journal Article
2003Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2002
: Fischer, R.; Schäffer, A.
Annual Report
2003The glutathion synthetase of Schizosaccharomyces pombe is synthesized as a homodimer but retains full activity when present as a heterotetramer
Phlippen, N.; Hoffmann, K.; Fischer, R.; Wolf, K.; Zimmermann, M.
Journal Article
2003Molecular farming in plants: Host systems and expression technology
Twyman, R.M.; Stoger, E.; Schillberg, S.; Christou, P.; Fischer, R.
Journal Article
2003Molecular farming of industrial proteins in plants
Fischer, R.; Emans, N.; Twyman, R.M.; Schillberg, S.
Book Article
2003Molecular farming of recombinant antibodies in plants
Schillberg, S.; Fischer, R.; Emans, N.
Journal Article
2003A novel approach for immunization, screening and characterization of selected scFv libraries using membrane fractions of tumor cells
Tur, M.K.; Rothe, A.; Huhn, M.; Goerres, U.; Klimka, A.; Stocker, M.; Engert, A.; Fischer, R.; Finnern, R.; Barth, S.
Journal Article
2003Production of antibodies in plants and their use for global health
Fischer, R.; Twyman, R.M.; Schillberg, S.
Journal Article
2003Production of therapeutic antibodies in plants
Nölke, G.; Fischer, R.; Schillberg, S.
Journal Article
2003Production of tumor-specific antibodies in tobacco
Vaquero-Martin, C.; Fischer, R.
Book Article
2003The recombinant anti-EGF receptor immunotoxin 425(scFv)-ETA' suppresses growth of a highly metastatic pancreatic carcinoma cell line
Bruell, D.; Stöcker, M.; Huhn, M.; Redding, N.; Küpper, M.; Schumacher, P.; Paetz, A.; Bruns, C.J.; Haisma, H.J.; Fischer, R.; Finnern, R.; Barth, S.
Journal Article
2003Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells
Tur, M.K.; Huhn, M.; Thepen, T.; Stocker, M.; Krohn, R.; Vogel, S.; Jost, E.; Osieka, R.; Winkel, J.G. van de; Fischer, R.; Finnern, R.; Barth, S.
Journal Article
2003An unusual internal ribosomal entry site of inverted symmetry directs expression of a potato leafroll polerovirus replication-associated protein
Jaag, H.M.; Kawchuk, L.; Rohde, W.; Fischer, R.; Emans, N.; Prüfer, D.
Journal Article
2003Using plants as a production system for N-Glycosylated proteins of therapeutic relevance
Hellwig, S.; Sack, M.; Spiegel, H.; Drossard, J.; Fischer, R.
Journal Article
2003Verfahren und Vorrichtung zur Sortierung kleiner Einheiten
Barth, S.; Vogel, S.; Fischer, R.; Gillner, A.; Wehner, M.
Patent
2003Vernetzte E-Wertschöpfung
Abele, H.; Dreher, C.; Eggers, T.; Fischer, R.; Hummel, V.; Sautter, A.
: Sihn, W.; Lay, G.
Study
2002Analysis of an anti-GnRH chimeric antibody purified from tobacco leaves
Nath, R.; Sack, M.; Finnern, R.; Talwar, G.P.; Fischer, R.
Poster
2002Antibody expression in plants
Verch, T.; Lewandowski, D.; Schillberg, S.; Yusibov, V.; Koprowski, H.; Fischer, R.
Book Article
2002Antibody molecular farming in plants and plant cells
Schillberg, S.; Emans, N.; Fischer, R.
Journal Article
2002A carcinoembryonic antigen-specific diabody produced in tobacco
Vaquero, C.; Sack, M.; Schuster, F.; Finnern, R.; Drossard, J.; Schumann, D.; Reimann, A.; Fischer, R.
Journal Article
2002Construction and characterization of a single-chain antibody fragment derived from thymus of a patient with myasthenia gravis
Meng, F.; Stassen, M.H.W.; Schillberg, S.; Fischer, R.; Baets, M.H. de
Journal Article
2002Design, assembly and characterization of a humanized scFv framework library
Spiegel, H.; Sack, M.; Finnern, R.; Fischer, R.
Presentation
2002Efficacy of plant-produced recombinant antibodies against HCG
Kathuria, S.; Sriraman, R.; Nath, R.; Sack, M.; Pal, R.; Artsaenko, O.; Talwar, G.P.; Fischer, R.; Finnern, R.
Journal Article
2002Entwicklung neuer Arzneimittel
Barth, S.; Finnern, R.; Fischer, R.; Hellwig, S.; Prüfer, D.
Journal Article
2002Fraktal+ Status quo der Studie "Vernetzte E-Wertschöpfung"
Fischer, R.
Conference Paper
2002Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2001
: Fischer, R.; Schäffer, A.
Annual Report
2002Functional recombinant antibodies against human chorionic gonadotropin expressed in plants
Kathuria, S.R.; Nath, R.; Pal, R.; Singh, O.; Fischer, R.; Lohiya, N.K.; Talwar, G.P.
Journal Article
2002Gene expression strategies of RNA viruses
Commandeur, U.; Rohde, W.; Fischer, R.; Prüfer, D.
Book Article
2002Molecular Farming
Commandeur, U.; Fischer, R.; Schillberg, S.
Journal Article
2002Molecular farming antibodies in plants
Fischer, R.; Finnern, R.; Emans, N.; Schillberg, S.
Book Article
2002Molecular Farming. Produktion hochwertiger Proteine in Pflanzen
Mavituna, M.; Schillberg, S.; Fischer, R.
Journal Article
2002Plantibodies. Applications, advantages and bottlenecks
Stoger, E.; Sack, M.; Fischer, R.; Christou, P.
Journal Article
2002Les planticorps
Stoger, E.; Sack, M.; Fischer, R.; Christou, P.
Journal Article
2002The potato granule bound starch synthase chloroplast transit peptide directs recombinant proteins to plastids
Hoppmann, V.; Fiore, S. di; Zimmermann, S.; Emans, N.; Rademacher, T.; Fischer, R.; Schillberg, S.
Journal Article
2002Practical considerations for pharmaceutical antibody production in different crop systems
Stoger, E.; Sack, M.; Perrin, Y.; Vaquero, C.; Torres, E.; Twyman, R.M.; Christou, P.; Fischer, R.
Journal Article
2002Rapid large-scale production of recombinant antibodies in agro-infiltrated leaves
Sack, M.; Vaquero, C.; Finnern, R.; Fischer, R.
Presentation
2002Sphaerische, magnetische Silica-Partikel mit einstellbarer Teilchen- und Porengroesse sowie einstellbarem Magnetgehalt fuer die Aufreinigung von Nukleinsaeuren und anderen Biomolekuelen
Fischer, R.; Mueller-Schulte, D.
Patent
2002Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype
Fiore, S. di; Li, Q.; Leech, M.J.; Schuster, F.; Emans, N.; Fischer, R.; Schillberg, S.
Journal Article
2002Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin
Emans, N.; Zimmermann, S.; Fischer, R.
Journal Article
2001Achieving plant disease resistance by antibody expression
Fischer, R.; Emans, N.; Schillberg, S.
Journal Article
2001Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations
Hellwig, S.; Emde, F.; Raven, N.P.G.; Henke, M.; Logt, P. van der; Fischer, R.
Journal Article
2001Antibody-based resistance to plant pathogens
Schillberg, S.; Zimmermann, S.; Zhang, M.Y.; Fischer, R.
Journal Article
2001Fraunhofer-Institut für Umweltchemie und Ökotoxikologie. Jahresbericht 2000
: Klein, W.; Fischer, R.; Schäffer, A.; Peine, B.
Annual Report
2001GST fusion proteins cause false positives during selection of viral movement protein specific single chain antibodies
Zhang, M.Y.; Schillberg, S.; Zimmermann, S.; Liao, Y.C.; Breuer, G.; Fischer, R.
Journal Article
2001Molecular evidence for induction of phenylalanine ammonia-lyase during Puccinia graminis infection and elicitation in wheat
Li, H.P.; Fischer, R.; Liao, Y.C.
Journal Article
2001Molecular Farming
Schillberg, S.; Fischer, R.
Journal Article
2001Molecular farming
Schillberg, S.; Fischer, R.
Book Article
2001Molecular farming of medicines. A field of growing promise
Fischer, R.; Schillberg, S.; Emans, N.
Journal Article
2001Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments
Torres, E.; Gonzalez-Melendi, P.; Stöger, E.; Shaw, P.; Twyman, R.M.; Nicholson, L.; Vaquero, C.; Fischer, R.; Christou, P.; Perrin, Y.
Journal Article
2001Polypeptid-Tag's fuer den Nachweis und die Aufreinigung von Polypeptiden
Fischer, R.; Helgers, Y.; Hoffmann, K.; Holzem, A.; Monecke, M.; Naehring, J.; Schillberg, S.
Patent
2001Produktion pharmazeutischer Proteine durch "Molecular Farming" in Pflanzen
Schillberg, S.; Fischer, R.
Journal Article
2001Rapid identification of a tobacco mosaic virus epitope by using a coat protein gene-fragment-pVIII fusion library
Holzem, A.; Nähring, J.; Fischer, R.
Journal Article
2001Tomato Ve disease resistance genes encode cell surface-like receptors
Kawchuk, L.; Hachey, J.; Lynch, D.R.; Kulcsar, F.; Rooijen, G. van; Waterer, D.R.; Robertson, A.; Kokko, E.; Byers, R.; Howard, R.J.; Fischer, R.; Prüfer, D.
Journal Article
2001Transgene Pflanzen als orale Impfstoffe. Grüne Revolution in der Medizin?
Commandeur, U.; Fischer, R.
Journal Article
2000Antibody production by molecular farming in plants
Fischer, R.; Hoffmann, K.; Schillberg, S.; Emans, N.
Journal Article
2000Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies
Stöger, E.; Vaquero, C.; Torres, E.; Sack, M.; Nicholson, L.; Drossard, J.; Williams, S.; Keen, D.; Perrin, Y.; Christou, P.; Fischer, R.
Journal Article
2000Fraunhofer-Institut für Umweltchemie und Ökotoxikologie. Jahresbericht 1999
: Klein, W.; Fischer, R.
Annual Report
2000Investigations into the Assembly of Multi-CCD Prism Beamsplitters for TV-Cameras
Tittelbach, G.; Guyenot, V.; Palme, M; Fischer, R.; Otto, E.; Sarbach, U.
Conference Paper
2000Molecular farming of clinically relevant recombinant antibody fragments
Steinbusch, U.; Kupper, M.; Fischer, R.; Finnern, R.
Journal Article
2000Molecular farming of pharmaceutical proteins
Fischer, R.; Emans, N.
Journal Article
2000The molecular farming of therapeutic antibodies
Fischer, R.; Vaquero, C.; Finnern, R.; Schillberg, S.
Conference Paper
2000Molekulares Farming. Die Pflanze als Biofabrik zur Produktion pharmazeutischer Proteine
Henke, M.; Schillberg, S.; Fischer, R.
Journal Article
2000Plasma membrane display of anti-viral single chain Fv fragments confers resistance to tobacco mosaic virus
Schillberg, S.; Zimmermann, S.; Findley, K.; Fischer, R.
Journal Article
2000Produktion rekombinanter Proteine durch "Molekulares Farming"
Schillberg, S.; Henke, M.; Fischer, R.
Journal Article
2000PV-EMI - Developing standard test procedures for the electromagnetic compatibility (EMC) of PV components and systems
Schattner, S.; Bopp, G.; Erge, T.; Fischer, R.; Häberlin, H.; Minkner, R.; Venhuizen, R.; Verhoeven, B.
Conference Paper
2000Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy
Perrin, Y.; Vaquero, C.; Gerrard, I.; Sack, M.; Drossard, J.; Stöger, E.; Christou, P.; Fischer, R.
Journal Article
2000Transient transformation of the rust fungus Puccinia graminis f. sp. tritici
Schillberg, S.; Tiburzy, R.; Fischer, R.
Journal Article
2000Untersuchungen zu Farbwiedergabeeigenschaften, Montage- und Fügeprozessen sowie der Prüfung von Mehrfach-CCD-Farbköpfen
Fischer, R.
Thesis
1999Accumulation of antibody fusion proteins in the cytoplasm and ER of plant cells
Spiegel, H.; Schillberg, S.; Sack, M.; Holzem, A.; Nähring, J.; Monecke, M.; Liao, Y.C.; Fischer, R.
Journal Article
1999Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture
Fischer, R.; Liao, Y.C.; Drossard, J.
Journal Article
1999Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum
Schillberg, S.; Zimmermann, S.; Voss, A.; Fischer, R.
Journal Article
1999Bauteil aus Holz sowie Verfahren zur Herstellung und Anwendung des Verfahrens
Fischer, R.; Haller, P.; Wiedemann, G.; Panzner, M.; Wust, H.
Patent
1999Engineering and expression of bispecific single chain Fv fragments in transgenic tobacco plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Immunological analysis of potato leafroll luteovirus (PLRV) P1 expression identifies a 25 kDa RNA-binding protein derived via P1 processing
Prüfer, D.; Kawchuk, L.; Monecke, M.; Nowok, S.; Fischer, R.; Rohde, W.
Journal Article
1999Laserinduzierte Modifikationen an Holzoberflächen
Wust, H.; Beyer, E.; Morgenthal, L.; Panzner, M.; Wiedemann, G.; Fischer, R.; Haller, P.
Journal Article
1999Molecular farming of recombinant antibodies in plants
Fischer, R.; Liao, Y.C.; Hoffmann, K.; Schillberg, S.; Emans, N.
Journal Article
1999Optimizing expression of a rare codon-rich viral protein in Escherichia coli using the IMPACT system
Zhang, M.Y.; Schillberg, S.; Prins, M.; Fischer, R.
Journal Article
1999Production of carcinoembryonic antigen (CEA) N-A3 domain in Pichia pastoris by fermentation
Hellwig, S.; Robin, F.; Drossard, J.; Raven, N.P.G.; Vaquero-Martin, C.; Shively, J.E.; Fischer, R.
Journal Article
1999Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies
Torres, E.; Vaquero, C.; Nicholson, L.; Sack, M.; Stöger, E.; Drossard, J.; Christou, P.; Fischer, R.; Perrin, Y.
Journal Article
1999Service Composition (SCO), Service Composition (MS3)
Born, M.; Fischer, R.
Report
1999Service Composition (SCO), Service Composition (MS4)
Born, M.; Fischer, R.
Report
1999Service Composition (SCO), Service Composition (MS5)
Born, M.; Fischer, R.
Report
1999Service Composition (SCO), Service Composition (MS6)
Born, M.; Fischer, R.
Report
1999Service Compositon in a TINA Environment
Born, M.; Fischer, R.; Löwis, v.; Krüger, D.; Ulbricht, C.
Conference Paper
1999Towards molecular farming in the future: moving from diagnostic protein and antibody production in microbes to plants
Fischer, R.; Drossard, J.; Commandeur, U.; Schillberg, S.; Emans, N.
Journal Article
1999Towards molecular farming in the future: Pichia pastoris-based production of single-chain antibody fragments
Fischer, R.; Drossard, J.; Emans, N.; Commandeur, U.; Hellwig, S.
Journal Article
1999Towards molecular farming in the future: transient protein expression in plants
Fischer, R.; Vaquero-Martin, C.; Sack, M.; Drossard, J.; Emans, N.; Commandeur, U.
Journal Article
1999Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors
Fischer, R.; Emans, N.; Schuster, F.; Hellwig, S.; Drossard, J.
Journal Article
1999Transgenic plants as bioreactors for the expression of recombinant antibodies and their downstream processing
Fischer, R.; Hellwig, S.; Drossard, J.; Emans, N.; Schillberg, S.
Conference Paper
1999Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves
Vaquero, C.; Sack, M.; Chandler, J.; Drossard, J.; Schuster, F.; Monecke, M.; Schillberg, S.; Fischer, R.
Journal Article
1998Experimental investigation of the laser ablation process on wood surfaces
Panzner, M.; Wiedemann, G.; Henneberg, K.; Fischer, R.; Witke, T.; Dietsch, R.
Conference Paper
1998Surface modification of wood by laser irradiation
Fischer, R.; Haller, P.; Panzner, M.; Wust, H.; Wiedemann, G.
Conference Paper
1998Transgenic plants as bioreactors for the expression of recombinant antibodies
Fischer, R.; Drossard, J.; Hellwig, S.; Emans, N.; Schillberg, S.
Conference Paper
1997Klassifikation von unterschiedlichen Holzqualitäten durch Farbtextur
Burmeister, A.; Fischer, R.
Conference Paper
1997Parallel Simulation mit der Methode der Finiten Elemente
Ho, D.P.; Fischer, R.; Krämer-Fuhrmann, O.
Journal Article
1997Production of engineered antibodies in tobacco plants and cell suspension cultures
Drossard, J.; Nähring, J.M.; Hellwig, S.; Fischer, R.
Conference Paper
1995Prozeß- und Erzeugnisinnovationen als Forschungsschwerpunkte
Fischer, R.; Fuchs, I.; Heisel, U.; Westkämper, E.
Journal Article
1994Analysis-aided geometric design based on constrained parametric structures
Fischer, R.; Vieira, A.S.; Rix, J.
Book Article
1994Aspekte des Laserstrahlschweißens von Komponenten für den Automobilbau
Klein, R.; Fischer, R.; Poprawe, R.; Zimmermann, K.
Conference Paper
1994Der Managementprozeß im Kontext der Logistik-Kooperation. Theoretische Überlegungen und empirische Befunde aus der Sicht der Zuliefererunternehmen
Fischer, R.
: Jünemann, R. (Prüfer)
Dissertation
1994Mehrwegtransportverpackungen - Einfluß auf die interne Logistik
Fischer, R.
Journal Article
1994Verfahren und Einrichtung zur Behandlung von Saatgut
Panzer, S.; Mueller, P.; Pflaumbaum, J.; Scholze, F.; Lange, M.; Mueller, R.; Motte, G.; Leja, M.; Fischer, R.; Gaber, K.; Jahn, M.
Patent
1993Schlank ohne Magersucht - Logistik - Ganzheitlich handeln
Fischer, R.; Lorenzen, K.-D.
Journal Article
1992Bestimmung potentieller Bereiche für die Make-or-buy-Untersuchung
Fischer, R.
Book Article
1992European priorities in science and technology with reference to freight logistics. Report. SAST Project No. 9
Schmidt, R.; Dreher, C.; Brugge, R.; Janssen, B.J.P.
: Boucon, T.; Buller, U.; Fischer, R.; Fuhrmann, R.; Geilleit, R.A.A.M.; Heger, D.; Jünemann, R.; Lay, G.; Lindenau, B.; Steusloff, H.
Book
1991Logistik - Optimierte Neugestaltung
Fischer, R.
Journal Article
1990Ion projection lithography - electronic alignment and dry development of IPL exposed resist materials
Buchmann, L.-M.; Heuberger, A.; Fallmann, W.; Paschke, F.; Stangl, G.; Chalupka, A.; Fegerl, J.; Löschner, H.; Malek, L.; Nowak, R.; Stengl, G.; Traher, C.; Wolf, P.; Fischer, R.
Journal Article
1990Wertschöpfungskette - Logistik optimieren
Fischer, R.
Journal Article
1987Meßmethode zur Bestimmung der Materialeigenschaften von Energieträgern bei hohen Dehngeschwindigkeiten
Fabry, C.; Sinn, F.; Fischer, R.; Geißler, A.; Kugler, H.P.
Conference Paper
1987Ortsaufgelöste Messung der Längsdehnung an Zugproben bis zu hohen Dehngeschwindigkeiten
Eisenreich, N.; Fischer, R.; Geißler, A.; Fabry, C.; Kugler, H.P.; Sinn, F.
Conference Paper
1987Strain distribution in the uniaxial tensile test up to high strain rates
Fabry, C.; Sinn, F.; Eisenreich, N.; Fischer, R.
Journal Article
1973Über beschränkte Interpolationsreihen mit n Stützstellen
Fischer, R.
Report