Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites
Chouman, Karinna; Korioth-Schmitz, Birgit; Sack, Markus; Engelbert Schmitz, Jörn; Tuan Pham, Anh; Fischer, Rainer; Barth, Stefan; Klockenbring, Torsten; Fendel, Rolf
Journal Article
2017Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13-ETA ' and the bispecific scFv [13xds16]
Grieger, E.; Gresch, G.; Niesen, J.; Woitok, M.; Barth, S.; Fischer, R.; Fendel, R.; Stein, C.
Journal Article
2017Generation of an artificial human B cell line test system using Transpo-mAb (TM) technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins
Klose, D.; Woitok, M.; Niesen, J.; Beerli, R.R.; Grawunder, U.; Fischer, R.; Barth, S.; Fendel, R.; Nachreiner, T.
Journal Article
2017Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candiate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRpm2 Does Not Improve the In Vitro Efficacy
Spiegel, H.; Boes, A.; Fendel, R.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2016Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria
Addai-Mensah, O.; Seidel, M.; Amidu, N.; Maskus, DJ.; Kapelski, S.; Breuer, G.; Franken, C.; Owusu-Dabo, E.; Frempong, M.; Rakotozandrindrainy, R.; Schinkel, H.; Reimann, A.; Klockenbring, T.; Barth, S.; Fischer, R.; Fendel, R.
Journal Article
2016Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail
Boes, A.; Spiegel, H.; Kastilan, R.; Bethke, S.; Voepel, N.; Chudobova, I.; Bolscher, J.M.; Dechering, K.J.; Fendel, R.; Buyel, J.F.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2016Anti-Parasitic Complexes
Fendel, Rolf; Kapelski, Stephanie; Barth, Stefan; Fischer, Rainer; Reimann, Andreas
Patent
2016Anti-plasmodium parasite antibodies
Fischer, Rainer; Reimann, Andreas; Maskus, Dominika Jacqueline; Fendel, Rolf; Klockenbring, Torsten
Patent
2016CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo
Mladenov, R.; Hristodorov, D.; Cremer, C.; Gresch, G.; Grieger, G.; Schenke, L.; Klose, D.; Amoury, M.; Woitok, M.; Jost, E.; Brümmerdorf, T.H.; Fendel, R.; Fischer, R.; Stein, C.; Thepen, T.; Barth, S.
Journal Article
2016Characterization of a novel inhibitory human monoclonal antibody directed against Plasmodium falciparum Apical Membrane Antigen 1
Maskus, D.J.; Królik, M.; Bethke, S.; Spiegel, H.; Kapelski, S.; Seidel, M.; Addai-Mensah, O.; Reimann, A.; Klockenbring, T.; Barth, S.; Fischer, R.; Fendel, R.
Journal Article
2016The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F
Woitok, M.; Klose, D.; Niesen, J.; Richter, W.; Abbas, M.; Stein, C.; Fendel, R.; Bialon, M.; Püttmann, C.; Fischer, R.; Barth, S.; Kolberg, K.
Journal Article
2016A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor
Niesen, J.; Hehmann-Titt, G.; Woitok, M.; Fendel, R.; Barth, S.; Fischer, R.; Stein, C.
Journal Article
2016SNAP-Tag Technology: A Useful Tool to Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments
Niesen, J.; Sack, M.; Seidel, M.; Fendel, R.; Barth, S.; Fischer, R.; Stein, C.
Journal Article
2015Analysis of a multi-component multi-stage malaria vaccine candidate-tackling the cocktail challenge
Boes, A.; Spiegel, H.; Voepel, N.; Edgue, G.; Beiss, V.; Kapelski, S.; Fendel, R.; Scheuermayer, M.; Pradel, G.; Bolscher, J.M.; Behet, M.C.; Dechering, K.J.; Hermsen, C.C.; Sauerwein, R.W.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein
Kapelski, S.; Almeida, M. de; Fischer, R.; Barth, S.; Fendel, R.
Journal Article
2015Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits
Boes, A.; Spiegel, H.; Edgue, G.; Kapelski, S.; Scheuermayer, M.; Fendel, R.; Remarque, E.; Altmann, F.; Maresch, D.; Reimann, A.; Pradel, G.; Schillberg, S.; Fischer, R.
Journal Article
2015Fast track antibody V-gene rescue, recombinant expression in plants and characterization of a PfMSP4-specific antibody
Kapelski, S.; Boes, A.; Spiegel, H.; Almeida, M. de; Klockenbring, T.; Reimann, A.; Fischer, R.; Barth, S.; Fendel, R.
Journal Article
2015Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein
Beiss, V.; Spiegel, H.; Boes, A.; Kapelski, S.; Scheuermayer, M.; Edgue, G.; Sack, M.; Fendel, R.; Reimann, A.; Schillberg, S.; Pradel, G.; Fischer, R.
Journal Article
2015Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10
Maskus, DJ.; Bethke, S.; Seidel, M.; Kapelski, S.; Addai-Mensah, O.; Boes, A.; Edgu, G.; Spiegel, H.; Reimann, A.; Fischer, R.; Barth, S.; Klockenbring, T.; Fendel, R.
Journal Article
2015Novel EGFR-specific immunotoxins based on panitumumab and cetuximab show in vitro and ex vivo activity against different tumor entities
Niesen, J.; Stein, C.; Brehm, H.; Hehmann-Titt, G.; Fendel, R.; Melmer, G.; Fischer, R.; Barth, S.
Journal Article
2015Optimization of a multi-stage, multi-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites
Spiegel, H.; Schinkel, H.; Kastilan, R.; Dahm, P.; Boes, A.; Scheuermayer, M.; Chudobova, I.; Maskus, D.; Fendel, R.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2014Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum
Kapelski, S.; Klockenbring, T.; Fischer, R.; Barth, S.; Fendel, R.
Journal Article
2014Malaria vaccine candidate antigen targeting the pre-erythrocytic stage of Plasmodium falciparum produced at high level in plants
Voepel, N.; Boes, A.; Edgue, G.; Beiss, V.; Kapelski, S.; Reimann, A.; Schillberg, S.; Pradel, G.; Fendel, R.; Scheuermayer, M.; Spiegel, H.; Fischer, R.
Journal Article
2014NOVEL ANTI-PLASMODIUM PARASITE ANTIBODIES
Kapelski, Stephanie; Maskus, Dominika Jacqueline; Fendel, Rolf; Klockenbring, Torsten; Barth, Stefan
Patent
2013Plant-based production of recombinant plasmodium surface protein Pf38 and evaluation of its potential as a vaccine candidate
Feller, Tanja; Thom, Pascal; Koch, Natalie; Spiegel, Holger; Addai-Mensah, Otchere; Fischer, Rainer; Reimann, Andreas; Pradel, Gabriele; Fendel, Rolf; Schillberg, Stefan; Scheuermayer, Matthias; Schinkel, Helga
Journal Article