Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018The application of new HARD-descriptor available from the CORAL software to building up NOAEL models
Toropova, Alla P.; Toropov, Andrey A.; Marzo, Marco; Escher, Sylvia E.; Dorne, Jean Lou; Georgiadis, Nikolaos; Benfenati, Emilio
Journal Article
2018Development of a novel scoring system for identifying emerging chemical risks in the food chain
Oltmanns, J.; Licht, O.; Bitsch, Annette; Bohlen, M.-L.; Escher, Sylvia E.; Silano, V.; MacLeod, M.; Serafimova, R.; Kass, G.E.N.; Merten, C.
Journal Article
2018Development of an updated carcinogenicity potency database and analysis of thresholds of toxicological concern
Cronin, M.T.D.; Belfield, S.; Escher, Sylvia E.; Firman, J.; Liu, J.; Marsaux, C.; Mostrag-Szlichtyng, A.; Przybylak, K.; Rathman, J.; Tarkhov, Aleksey; Yang, C.
Abstract
2018EUToxRisk case studies: new approach methodologies in read-across
Escher, Sylvia E.
Abstract
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2018High throughput adaptive stress response pathway activation to support read across of valproic acid analogue-induced liver steatosis
Vrijenhoek, N.G.; Gräpel, Rabea; Wink, S.; Escher, Sylvia E.; Water, Bob van de
Abstract
2018High-throughput microscopy of adaptive stress response pathway activation by steatosis-inducing valproic acid analogues
Vrijenhoek, N.G.; Gräpel, Rabea; Escher, Sylvia E.; Water, Bob van de
Abstract
2018In vitro to in vivo extrapolation of valproic acid hepatotoxicity: A biokinetic and physiologically based toxicokinetic informed approach
Fisher, C.P.; Hatley, O.; Vugt, B. van; Bois, F.; Escher, Sylvia E.; Gardner, Iain
Abstract
2018Physiologisch basierte toxikokinetische (PBTK) Modellierung zur Aufnahme von Chemikalien/Aerosolen über die Lunge
Winkler, Daniel Sandro
: Escher, Sylvia E. (Betr.); Esch, Christina (Betr.)
Master Thesis
2018Prediction of microvesicular liver steatosis: a read-across case study with branched carboxylic acids
Escher, Sylvia E.; Tolosa Pardo, L.; Maclennan, R.; Stöber, R.; Limonciel, A.; Fisher, C.; Brotzmann, K.; Vugt-Lussenburg, B.M. van; Vrijenhoek, N.G.; Gräpel, R.
Abstract
2018Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes
Grinberg, Marianna; Stöber, Regina M.; Albrecht, Wiebke; Edlund, Karolina; Schug, Markus; Godoy, Patricio; Cadenas, Cristina; Marchan, Rosemarie; Lampen, Alfonso; Braeuning, Albert; Buhrke, Thorsten; Leist, Marcel; Oberemm, Axel; Hellwig, Birte; Kamp, Hennicke; Gardner, Iain; Escher, Sylvia E.; Taboureau, Olivier; Aguayo-Orozco, Alejandro; Sachinidis, Agapios; Ellinger-Ziegelbauer, Heidrun; Rahnenfuhrer, Jörg; Hengstler, Jan G.
Journal Article
2018Use of new approach methods to support chemical read-across: The EU-ToxRisk experience
Water, Bob van de; Kamp, Hennicke; Escher, Sylvia E.; Kroese, Dinant
Abstract
2017Curated human hyperbilirubinemia data and the respective OATP1B1 and 1B3 inhibition predictions
Kotsampasakou, Eleni; Escher, Sylvia E.; Ecker, Gerhard F.
Journal Article
2017In silico toxicology: An overview of toxicity databases, prediction methodologies, and expert review
Bower, D.; Cross, K.P.; Escher, Sylvia E.; Myatt, Glenn J.; Quigley, D.P.
Book Article
2017Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case
Kotsampasakou, Eleni; Escher, Sylvia E.; Ecker, Gerhard F.
Journal Article
2017Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected β-olefinic alcohols
Przybylak, Katarzyna R.; Schultz, Terry W.; Richarz, Andrea-N.; Mellor, Claire L.; Escher, Sylvia E.; Cronin, M.T.D.
Journal Article
2017Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected n-alkanols
Schultz, Terry W.; Przybylak, Katarzyna R.; Richarz, Andrea-Nicole; Mellor, Claire L.; Escher, Sylvia E.; Bradbury, Steven P.; Cronin, Mark T.D.
Journal Article
2016"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015
Fernando, Ruani N.; Chaudhari, Umesh; Escher, Sylvia E.; Hengstler, Jan G.; Hescheler, Jürgen; Jennings, Paul; Keun, Hector C.; Kleinjans, Jos C.S.; Kolde, Raivo; Kollipara, Laxmikanth; Kopp-Schneider, Annette; Limonciel, Alice; Nemade, Harshal; Nguemo, Filomain; Peterson, Hedi; Prieto, Pilar; Rodrigues, Robim M.; Sachinidis, Agapios; Schäfer, Christoph; Sickmann, Albert; Spitkovsky, Dimitry; Stöber, Regina M.; Breda, Simone G.J. van; Water, Bob van de; Vivier, Manon; Zahedi, Rene P.; Vinken, Mathieu; Rogiers, Vera
Journal Article
2016Evaluation of route-to-route extrapolation factors based on assessment of repeated dose toxicity studies compiled in the database RepDose®
Schröder, Katrin; Escher, Sylvia E.; Hoffmann-Dörr, Simone; Kühne, R.; Simetska, Nelly; Mangelsdorf, Inge
Journal Article
2016Inhalation TTC values: A new integrative grouping approach considering structural, toxicological and mechanistic features
Tluczkiewicz, Inga; Kühne, Ralph; Ebert, Ralf-Uwe; Batke, Monika; Schüürmann, Gerrit; Mangelsdorf, Inge; Escher, Sylvia E.
Journal Article
2015Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Species comparison of rat and human precision-cut lung slices as an alternative in risk assessment based on read-across approach
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Bersch, Claus; Braubach, Peter; Jonigk, Danny; Pfennig, Olaf; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Structural features of endocrine active chemicals - a comparison of in vivo and in vitro data
Lewin, Geertje; Escher, Sylvia E.; Burg, Bart van der; Simetska, Nelly; Mangelsdorf, Inge
Journal Article
2015TTC concept: Non-oral routes and influence of local effects
Escher, Sylvia E.
Abstract
2015Update of time extrapolation factors for risk assessment: The benefit of combined databases and probabilistic analyses
Escher, Sylvia E.; Hoffmann-Doerr, Simone; Pastor, Manuel; Partosch, Falko; Schröder, Katrin; Mangelsdorf, Inge
Abstract
2015The use of AOPs in risk assessment: Development of biomarker based on a read across use case on VPA analogues in the Detective project
Stöber, Werner; Steger-Hartmann, Thomas; Myatt, Glenn J.; Richarz, Andrea; Hengstler, Jan; Escher, Sylvia E.
Abstract
2015VPA Read across: Development of predictive biomarkers by using toxicity data of structurally similar compounds
Stöber, Regina; Escher, Sylvia E.; Hengstler, Jan G.
Abstract
2014A k-NN algorithm for predicting oral sub-chronic toxicity in the rat
Gadaleta, Domenico; Pizzo, Fabiola; Lombardo, Anna; Carotti, Angelo; Escher, Sylvia E.; Nicolotti, Orazio; Benfenati, Emilio
Journal Article
2013The OSIRIS weight of evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS)
Tluczkiewicz, Inga; Batke, Monika; Kroese, Dinant; Buist, Harrie; Aldenberg, Tom; Pauné, Eduard; Grimm, Helvi; Kühne, Ralph; Schüürmann, Gerrit; Mangelsdorf, Inge; Escher, Sylvia E.
Journal Article
2012OpenTox predictive toxicology framework
Tcheremenskaia, Olga; Benigni, Romualdo; Nikolova, Ivelina; Jeliazkova, Nina; Escher, Sylvia E.; Batke, Monika; Baier, Thomas; Poroikov, Vladimir; Lagunin, Alexey; Rautenberg, Micha; Hardy, Barry
Journal Article