Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2015Comparative data-mining across multiple toxicity databases harmonized by eTOX ontology to test hypotheses
Steger-Hartmann, T.; Pognan, F.; Sanz, F.; Briggs, K.; Escher, Sylvia; Kleinoeder, T.; Schwab, C.; Wichard, J.; Yang, C.
Abstract
2015Support for the use of computer-based predictions like quantitative structure-activity relationships (QSAR methods) to avoid animal testing under REACH
Escher, Sylvia; Batke, Monika; Arning, Jürgen; Brandt, Marc; Kupper, Jürgen; Eifert, Harald; Wibbertmann, Axel
Abstract
20141. Welche Auswirkung hat "Hungern" in Toxizitätsstudien mit wiederholter Verabreichung? 2. Prädiktivität von Organgewichten - Organgewicht als Biomarker in der Toxikologie?
Schweiger, Julietta Ursula
: Escher, Sylvia (1. Gutachter); Stahlmann, Ralf (2. Gutachter)
Master Thesis
2014Alternative model for repeated dose inhalation toxicity using precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Sylvia; Schaudien, Dirk; Braun, Armin; Sewald, Katherina
Abstract
2014Analysing reproductive toxicity studies using the FeDTex database - does an F2-generation provide an additional benefit?
Schulz, Florian; Lewin, Geertje; Mangelsdorf, Inge; Batke, Monika; Escher, Sylvia
Journal Article, Conference Paper
2014Carcinogenicity and mutagenicity of nanoparticles - assessment of current knowledge as basis for regulation
Schröder, Katrin; Polenz-Michel, Christina; Simetska, Nelly; Voss, Jens-Uwe; Escher, Sylvia; Mangelsdorf, Inge
Report
2014Development of an in silico pre-screen for reproductive toxicity within the EU project ChemScreen
Lewin, Geertje; Burg, Bart van der; Batke, Monika; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2014Improvement of the TTC concept for oral and inhalation exposure and its application in an Integrated Testing Strategy (ITS) for the endpoint repeated-dose toxicity
Tluczkiewicz, Inga
: Schüürmann, Gerrit (Supervisor); Escher, Sylvia (Advisor)
Dissertation
2014Route to route extrapolation factors for regulatory risk assessment - a probabilistic approach
Schröder, Katrin; Hoffmann-Dörr, Simone; Mangelsdorf, Inge; Escher, Sylvia
Abstract
2014Toxicogenomics directory of chemically exposed human hepatocytes
Grinberg, Marianna; Stöber, Regina M.; Edlund, Karolina; Rempel, Eugen; Godoy, Patricio; Reif, Raymond; Widera, Agata; Madjar, Katrin; Schmidt-Heck, Wolfgang; Marchan, Rosemarie; Sachinidis, Agapios; Spitkovsky, Dimitry; Hescheler, Jürgen; Carmo, Helena; Arbo, Marcelo D.; Water, Bob van de; Wink, Steven; Vinken, Mathieu; Rogiers, Vera; Escher, Sylvia; Hardy, Barry; Mitic, Dragana; Myatt, Glenn; Waldmann, Tanja; Mardinoglu, Adil; Damm, Georg; Seehofer, Daniel; Nüssler, Andreas; Weiss, Thomas S.; Oberemm, Axel; Lampen, Alfons; Schaap, Mirjam M.; Luijten, Mirjam; Steeg, Harry van; Thasler, Wolfgang E.; Kleinjans, Jos C.S.; Stierum, Rob H.; Leist, Marcel; Rahnenführer, Jürgen; Hengstler, Jan G.
Journal Article
2014Toxicological databases: Modern tools to reduce, refine and replace animal testing
Schröder, Katrin; Simetska, Nelly; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2014TTC: A new concept for inhalation exposure
Tluczkiewicz, Inga; Batke, Monika; Kühne, Ralph; Schüürmann, Gerrit; Mangelsdorf, Inge; Escher, Sylvia
Journal Article, Conference Paper
2014TTC: A new concept for inhalation exposure
Escher, Sylvia; Tluczkiewicz, Inga; Batke, Monika; Kühne, Ralf; Ebert, Ralf-Uwe; Schüürmann, Gerrit; Mangelsdorf, Inge
Abstract
2013Analysis of the indicative value of repeated dose toxicity studies for reproductive toxicity
Lewin, Geertje; Batke, Monika; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2013Assessment factors in human health risk assessment and their associated level of safety
Escher, Sylvia; Hoffmann-Doerr, S.; Batke, Monika; Mangelsdorf, Inge
Journal Article, Conference Paper
2013Development of a database on toxic effects of nano-objects
Schröder, Katrin; Pohlenz-Michel, Christina; Voß, Jens-Uwe; Simetska, Nelly; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2013FeDTex database - a versatile tool condensing data from developmental and reproductive toxicity studies
Schulz, Florian; Batke, Monika; Lewin, Geertje; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2013The OSIRIS weight of evidence approach: ITS mutagenicity and ITS carcinogenicity
Buist, Harrie; Aldenberg, Tom; Batke, Monika; Escher, Sylvia; Klein, Entink R.; Kühne, Ralph; Marquart, Hans; Pauné, Eduard; Rorije, Emiel; Schüürmann, Gerrit; Kroese, Dinant
Journal Article
2013OSIRIS, a quest for proof of principle for integrated testing strategies of chemicals for four human health endpoints
Vermeire, Theo; Aldenberg, Tom; Buist, Harrie; Escher, Sylvia; Mangelsdorf, Inge; Pauné, Eduard; Rorije, Emiel; Kroese, Dinant
Journal Article
2013Relevance of non-guideline studies for risk assessment. The coverage model based on most frequent targets in repeated dose toxicity studies
Batke, Monika; Aldenberg, Tom; Escher, Sylvia; Mangelsdorf, Inge
Journal Article
2012Derived values and databases for non-cancer endpoints: Considerations and concerns
Tluczkiewicz, Inga; Batke, Monika; Mangelsdorf, Inge; Escher, Sylvia
Journal Article, Conference Paper

 

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