Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Analyses of frequency and sensitivity of affected organs in preclinical studies from RepDose and eTOX database
Afrapoli, F.M.; Escher, S.E.; Bitsch, A.; Simetska, N.
Abstract
2019Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop
Ellison, C.A.; Blackburn, K.L.; Carmichael, P.L.; Clewell, H.J.; Cronin, M.T.D.; Desprez, B.; Escher, S.E.; Ferguson, S.S.; Grégoire, S.; Hewitt, N.J.; Hollnagel, H.M.; Klaric, M.; Patel, A.; Salhi, S.; Schepky, A.; Schmitt, B.G.; Wambaugh, J.F.; Worth, A.
Journal Article
2019Corrigendum to "The application of new HARD-descriptor available from the CORAL software to building up NOAEL models" [Food Chem. Toxicol. 112 (2018) 544-550]
Toropova, A.P.; Toropov, A.A.; Marzo, M.; Escher, S.E.; Dorne, J.L.; Georgiadis, N.; Benfenati, E.
Journal Article
2019Development of a QSAR model for respiratory irritation
Wehr, M.; Karwath, A.; Sarang, S.S.; Rooseboom, M.; Boogaard, P.J.; Escher, S.E.
Abstract
2019Identification of potential emerging chemical risks in food from REACH registered chemicals
Licht, O.; Bitsch, A.; Bohlen, M.L.; Escher, S.E.; Kass, G.; Merten, C.; MacLeod, M.; Noteborn, H.; Schwarz, M.; Oltmanns, J.; Silano, V.
Abstract
2019Paradigm shift in safety assessment using new approach methods
Graepel, R.; Ter Braak, B.; Escher, S.E.; Fisher, C.; Gardner, I.; Kamp, H.; Kroese, D.; Leist, M.; Moné, M.J.; Pastor, M.; Water, B. van de
Journal Article
2018The application of new HARD-descriptor available from the CORAL software to building up NOAEL models
Toropova, Alla P.; Toropov, Andrey A.; Marzo, Marco; Escher, Sylvia E.; Dorne, Jean Lou; Georgiadis, Nikolaos; Benfenati, Emilio
Journal Article
2018Development of a novel scoring system for identifying emerging chemical risks in the food chain
Oltmanns, J.; Licht, O.; Bitsch, Annette; Bohlen, M.-L.; Escher, Sylvia E.; Silano, V.; MacLeod, M.; Serafimova, R.; Kass, G.E.N.; Merten, C.
Journal Article
2018Development of an updated carcinogenicity potency database and analysis of thresholds of toxicological concern
Cronin, M.T.D.; Belfield, S.; Escher, Sylvia E.; Firman, J.; Liu, J.; Marsaux, C.; Mostrag-Szlichtyng, A.; Przybylak, K.; Rathman, J.; Tarkhov, Aleksey; Yang, C.
Abstract
2018EUToxRisk case studies: new approach methodologies in read-across
Escher, Sylvia E.
Abstract
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2018High throughput adaptive stress response pathway activation to support read across of valproic acid analogue-induced liver steatosis
Vrijenhoek, N.G.; Gräpel, Rabea; Wink, S.; Escher, Sylvia E.; Water, Bob van de
Abstract
2018High-throughput microscopy of adaptive stress response pathway activation by steatosis-inducing valproic acid analogues
Vrijenhoek, N.G.; Gräpel, Rabea; Escher, Sylvia E.; Water, Bob van de
Abstract
2018In vitro to in vivo extrapolation of valproic acid hepatotoxicity: A biokinetic and physiologically based toxicokinetic informed approach
Fisher, C.P.; Hatley, O.; Vugt, B. van; Bois, F.; Escher, Sylvia E.; Gardner, Iain
Abstract
2018Physiologisch basierte toxikokinetische (PBTK) Modellierung zur Aufnahme von Chemikalien/Aerosolen über die Lunge
Winkler, Daniel Sandro
: Escher, Sylvia E. (Betr.); Esch, Christina (Betr.)
Master Thesis
2018Prediction of microvesicular liver steatosis: a read-across case study with branched carboxylic acids
Escher, Sylvia E.; Tolosa Pardo, L.; Maclennan, R.; Stöber, R.; Limonciel, A.; Fisher, C.; Brotzmann, K.; Vugt-Lussenburg, B.M. van; Vrijenhoek, N.G.; Gräpel, R.
Abstract
2018Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes
Grinberg, Marianna; Stöber, Regina M.; Albrecht, Wiebke; Edlund, Karolina; Schug, Markus; Godoy, Patricio; Cadenas, Cristina; Marchan, Rosemarie; Lampen, Alfonso; Braeuning, Albert; Buhrke, Thorsten; Leist, Marcel; Oberemm, Axel; Hellwig, Birte; Kamp, Hennicke; Gardner, Iain; Escher, Sylvia E.; Taboureau, Olivier; Aguayo-Orozco, Alejandro; Sachinidis, Agapios; Ellinger-Ziegelbauer, Heidrun; Rahnenfuhrer, Jörg; Hengstler, Jan G.
Journal Article
2018Use of new approach methods to support chemical read-across: The EU-ToxRisk experience
Water, Bob van de; Kamp, Hennicke; Escher, Sylvia E.; Kroese, Dinant
Abstract
2017Adverse outcome pathways: Opportunities, limitations and open questions
Leist, M.; Ghallab, A.; Graepel, R.; Marchan, R.; Hassan, R.; Bennekou, S.H.; Limonciel, A.; Vinken, M.; Schildknecht, S.; Waldmann, T.; Danen, E.; Ravenzwaay, B. van; Kamp, H.; Gardner, I.; Godoy, P.; Bois, F.Y.; Braeuning, A.; Reif, R.; Oesch, F.; Drasdo, D.; Höhme, S.; Schwarz, M.; Hartung, T.; Braunbeck, T.; Beltman, J.; Vrieling, H.; Sanz, F.; Forsby, A.; Gadaleta, D.; Fisher, C.; Kelm, J.; Fluri, D.; Ecker, G.; Zdrazil, B.; Terron, A.; Jennings, P.; Burg, B. van der; Dooley, S.; Meijer, A.H.; Willighagen, E.; Martens, M.; Evelo, C.; Mombelli, E.; Taboureau, O.; Mantovani, A.; Hardy, B.; Koch, B.; Escher, S.; Thriel, C. van; Cadenas, C.; Kroese, D.; Water, B. van de; Hengstler, J.G.
Journal Article
2017Curated human hyperbilirubinemia data and the respective OATP1B1 and 1B3 inhibition predictions
Kotsampasakou, Eleni; Escher, Sylvia E.; Ecker, Gerhard F.
Journal Article
2017In silico toxicology: An overview of toxicity databases, prediction methodologies, and expert review
Bower, D.; Cross, K.P.; Escher, Sylvia E.; Myatt, Glenn J.; Quigley, D.P.
Book Article
2017Legacy data sharing to improve drug safety assessment
Sanz, F.; Pognan, F.; Steger-Hartmann, T.; Díaz, C.; Cases, M.; Pastor, M.; Marc, P.; Wichard, J.; Briggs, K.; Watson, D.K.; Kleinöder, T.; Yang, C.; Amberg, A.; Beaumont, M.; Brookes, A.J.; Brunak, S.; Cronin, M.T.D.; Ecker, G.F.; Escher, S.; Greene, N.; Guzmán, A.; Hersey, A.; Jacques, P.; Lammens, L.; Mestres, J.; Muster, W.; Northeved, H.; Pinches, M.; Saiz, J.; Sajot, N.; Valencia, A.; Lei,, J. van der; Vermeulen, N.P.E.; Vock, E.; Wolber, G.; Zamora, I.
Journal Article
2017Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case
Kotsampasakou, Eleni; Escher, Sylvia E.; Ecker, Gerhard F.
Journal Article
2017Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected β-olefinic alcohols
Przybylak, Katarzyna R.; Schultz, Terry W.; Richarz, Andrea-N.; Mellor, Claire L.; Escher, Sylvia E.; Cronin, M.T.D.
Journal Article
2017Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected n-alkanols
Schultz, Terry W.; Przybylak, Katarzyna R.; Richarz, Andrea-Nicole; Mellor, Claire L.; Escher, Sylvia E.; Bradbury, Steven P.; Cronin, Mark T.D.
Journal Article
2016"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015
Fernando, Ruani N.; Chaudhari, Umesh; Escher, Sylvia E.; Hengstler, Jan G.; Hescheler, Jürgen; Jennings, Paul; Keun, Hector C.; Kleinjans, Jos C.S.; Kolde, Raivo; Kollipara, Laxmikanth; Kopp-Schneider, Annette; Limonciel, Alice; Nemade, Harshal; Nguemo, Filomain; Peterson, Hedi; Prieto, Pilar; Rodrigues, Robim M.; Sachinidis, Agapios; Schäfer, Christoph; Sickmann, Albert; Spitkovsky, Dimitry; Stöber, Regina M.; Breda, Simone G.J. van; Water, Bob van de; Vivier, Manon; Zahedi, Rene P.; Vinken, Mathieu; Rogiers, Vera
Journal Article
2016Evaluation of route-to-route extrapolation factors based on assessment of repeated dose toxicity studies compiled in the database RepDose®
Schröder, Katrin; Escher, Sylvia E.; Hoffmann-Dörr, Simone; Kühne, R.; Simetska, Nelly; Mangelsdorf, Inge
Journal Article
2016Inhalation threshold of toxicological concern (TTC) - structural alerts discriminate high from low repeated-dose inhalation toxicity
Schüürmann, Gerrit; Ebert, Ralf-Uwe; Tluczkiewicz, Inga; Escher, S.E.; Kühne, R.
Journal Article
2016Inhalation TTC values: A new integrative grouping approach considering structural, toxicological and mechanistic features
Tluczkiewicz, Inga; Kühne, Ralph; Ebert, Ralf-Uwe; Batke, Monika; Schüürmann, Gerrit; Mangelsdorf, Inge; Escher, Sylvia E.
Journal Article
2016Thresholds of toxicological concern - overview of ongoing scientific developments
Escher, S.; Turek, C.; Campos, S.; Edwards, J.; Ferret, P.; Höfer, N.; Kosemund, K.; Schnabel, J.; Ravenzwaay, B. van; Hollnagel, H.M.
Abstract
2016Tierversuchsfreie Methoden in der Toxikologie
Koschmann, J.; Sewald, K.; Escher, S.E.
Journal Article
2015Comparative data-mining across multiple toxicity databases harmonized by eTOX ontology to test hypotheses
Steger-Hartmann, T.; Pognan, F.; Sanz, F.; Briggs, K.; Escher, Sylvia; Kleinoeder, T.; Schwab, C.; Wichard, J.; Yang, C.
Abstract
2015DETECTIVE: Detection of Endpoints and Biomarkers for Repeated Dose Toxicity using in vitro Systems
Wink, S.; Water, B. van de; Reif, R.; Hammad, S.; Stöber, R.; Widera, A.; Hengstler, J.; Limonciel, A.; Jennings, P.; Escher, S.; Keun, H.; Kleinjans, J.; Kopp-Schneider, A.; Peterson, H.; Ringwald, A.; Rogiers, V.; Sachinidis, A.; Sickmann, A.; Vinken, M.; Spitkovsky, D.; Hescheler, J.
Book Article
2015Development of Biomarker Based on a Read-Across Use Case on Valproic Acid Analogues
Escher, S.; Hengstler, J.
Book Article
2015Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Precision-cut lung slices as an alternative model for repeated-dose inhalation toxicity
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Syliva; Braun, Armin; Sewald, Katherina
Abstract
2015Risk assessment of inhalable read-across chemicals with different mode of action showed great differences in cytotoxicity in rat and human precision-cut lung slices
Danov, Olga; Schröder, Katrin; Braubach, Peter; Jonigk, D.; Warnecke, G.; Braun, Armin; Escher, Syliva; Sewald, Katherina
Abstract
2015Species comparison of rat and human precision-cut lung slices as an alternative in risk assessment based on read-across approach
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Bersch, Claus; Braubach, Peter; Jonigk, Danny; Pfennig, Olaf; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Structural features of endocrine active chemicals - a comparison of in vivo and in vitro data
Lewin, Geertje; Escher, Sylvia E.; Burg, Bart van der; Simetska, Nelly; Mangelsdorf, Inge
Journal Article
2015Support for the use of computer-based predictions like quantitative structure-activity relationships (QSAR methods) to avoid animal testing under REACH
Escher, Sylvia; Batke, Monika; Arning, Jürgen; Brandt, Marc; Kupper, Jürgen; Eifert, Harald; Wibbertmann, Axel
Abstract
2015TTC concept: Non-oral routes and influence of local effects
Escher, Sylvia E.
Abstract
2015Update of time extrapolation factors for risk assessment: The benefit of combined databases and probabilistic analyses
Escher, Sylvia E.; Hoffmann-Doerr, Simone; Pastor, Manuel; Partosch, Falko; Schröder, Katrin; Mangelsdorf, Inge
Abstract
2015The use of AOPs in risk assessment: Development of biomarker based on a read across use case on VPA analogues in the Detective project
Stöber, Werner; Steger-Hartmann, Thomas; Myatt, Glenn J.; Richarz, Andrea; Hengstler, Jan; Escher, Sylvia E.
Abstract
2015VPA Read across: Development of predictive biomarkers by using toxicity data of structurally similar compounds
Stöber, Regina; Escher, Sylvia E.; Hengstler, Jan G.
Abstract
20141. Welche Auswirkung hat "Hungern" in Toxizitätsstudien mit wiederholter Verabreichung? 2. Prädiktivität von Organgewichten - Organgewicht als Biomarker in der Toxikologie?
Schweiger, Julietta Ursula
: Escher, Sylvia (1. Gutachter); Stahlmann, Ralf (2. Gutachter)
Master Thesis
2014Alternative model for repeated dose inhalation toxicity using precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Sylvia; Schaudien, Dirk; Braun, Armin; Sewald, Katherina
Abstract
2014Analysing reproductive toxicity studies using the FeDTex database - does an F2-generation provide an additional benefit?
Schulz, Florian; Lewin, Geertje; Mangelsdorf, Inge; Batke, Monika; Escher, Sylvia
Journal Article, Conference Paper
2014Carcinogenicity and mutagenicity of nanoparticles - assessment of current knowledge as basis for regulation
Schröder, Katrin; Polenz-Michel, Christina; Simetska, Nelly; Voss, Jens-Uwe; Escher, Sylvia; Mangelsdorf, Inge
Report
2014Development of an in silico pre-screen for reproductive toxicity within the EU project ChemScreen
Lewin, Geertje; Burg, Bart van der; Batke, Monika; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2014Improvement of the TTC concept for oral and inhalation exposure and its application in an Integrated Testing Strategy (ITS) for the endpoint repeated-dose toxicity
Tluczkiewicz, Inga
: Schüürmann, Gerrit (Supervisor); Escher, Sylvia (Advisor)
Dissertation
2014A k-NN algorithm for predicting oral sub-chronic toxicity in the rat
Gadaleta, Domenico; Pizzo, Fabiola; Lombardo, Anna; Carotti, Angelo; Escher, Sylvia E.; Nicolotti, Orazio; Benfenati, Emilio
Journal Article
2014Route to route extrapolation factors for regulatory risk assessment - a probabilistic approach
Schröder, Katrin; Hoffmann-Dörr, Simone; Mangelsdorf, Inge; Escher, Sylvia
Abstract
2014Toxicogenomics directory of chemically exposed human hepatocytes
Grinberg, Marianna; Stöber, Regina M.; Edlund, Karolina; Rempel, Eugen; Godoy, Patricio; Reif, Raymond; Widera, Agata; Madjar, Katrin; Schmidt-Heck, Wolfgang; Marchan, Rosemarie; Sachinidis, Agapios; Spitkovsky, Dimitry; Hescheler, Jürgen; Carmo, Helena; Arbo, Marcelo D.; Water, Bob van de; Wink, Steven; Vinken, Mathieu; Rogiers, Vera; Escher, Sylvia; Hardy, Barry; Mitic, Dragana; Myatt, Glenn; Waldmann, Tanja; Mardinoglu, Adil; Damm, Georg; Seehofer, Daniel; Nüssler, Andreas; Weiss, Thomas S.; Oberemm, Axel; Lampen, Alfons; Schaap, Mirjam M.; Luijten, Mirjam; Steeg, Harry van; Thasler, Wolfgang E.; Kleinjans, Jos C.S.; Stierum, Rob H.; Leist, Marcel; Rahnenführer, Jürgen; Hengstler, Jan G.
Journal Article
2014Toxicological databases: Modern tools to reduce, refine and replace animal testing
Schröder, Katrin; Simetska, Nelly; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2014TTC: A new concept for inhalation exposure
Tluczkiewicz, Inga; Batke, Monika; Kühne, Ralph; Schüürmann, Gerrit; Mangelsdorf, Inge; Escher, Sylvia
Journal Article, Conference Paper
2014TTC: A new concept for inhalation exposure
Escher, Sylvia; Tluczkiewicz, Inga; Batke, Monika; Kühne, Ralf; Ebert, Ralf-Uwe; Schüürmann, Gerrit; Mangelsdorf, Inge
Abstract
2013Analysis of the indicative value of repeated dose toxicity studies for reproductive toxicity
Lewin, Geertje; Batke, Monika; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2013Assessment factors in human health risk assessment and their associated level of safety
Escher, Sylvia; Hoffmann-Doerr, S.; Batke, Monika; Mangelsdorf, Inge
Journal Article, Conference Paper
2013Development of a database on toxic effects of nano-objects
Schröder, Katrin; Pohlenz-Michel, Christina; Voß, Jens-Uwe; Simetska, Nelly; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2013FeDTex database - a versatile tool condensing data from developmental and reproductive toxicity studies
Schulz, Florian; Batke, Monika; Lewin, Geertje; Escher, Sylvia; Mangelsdorf, Inge
Journal Article, Conference Paper
2013Interspecies extrapolation based on the RepDose database
Escher, S.E.; Batke, M.; Hoffmann-Doerr, S.; Messinger, H.; Mangelsdorf, I.
Journal Article
2013The OSIRIS weight of evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS)
Tluczkiewicz, Inga; Batke, Monika; Kroese, Dinant; Buist, Harrie; Aldenberg, Tom; Pauné, Eduard; Grimm, Helvi; Kühne, Ralph; Schüürmann, Gerrit; Mangelsdorf, Inge; Escher, Sylvia E.
Journal Article
2013The OSIRIS weight of evidence approach: ITS mutagenicity and ITS carcinogenicity
Buist, Harrie; Aldenberg, Tom; Batke, Monika; Escher, Sylvia; Klein, Entink R.; Kühne, Ralph; Marquart, Hans; Pauné, Eduard; Rorije, Emiel; Schüürmann, Gerrit; Kroese, Dinant
Journal Article
2013OSIRIS, a quest for proof of principle for integrated testing strategies of chemicals for four human health endpoints
Vermeire, Theo; Aldenberg, Tom; Buist, Harrie; Escher, Sylvia; Mangelsdorf, Inge; Pauné, Eduard; Rorije, Emiel; Kroese, Dinant
Journal Article
2013Relevance of non-guideline studies for risk assessment. The coverage model based on most frequent targets in repeated dose toxicity studies
Batke, Monika; Aldenberg, Tom; Escher, Sylvia; Mangelsdorf, Inge
Journal Article
2012Derived values and databases for non-cancer endpoints: Considerations and concerns
Tluczkiewicz, Inga; Batke, Monika; Mangelsdorf, Inge; Escher, Sylvia
Journal Article, Conference Paper
2012Food for thought... A toxicology ontology roadmap
Hardy, B.; Apic, G.; Carthew, P.; Clark, D.; Cook, D.; Dix, I.; Escher, S.; Hastings, J.; Heard, D.J.; Jeliazkova, N.; Judson, P.; Matis-Mitchell, S.; Mitic, D.; Myatt, G.; Shah, I.; Spjuth, O.; Tcheremenskaia, O.; Toldo, L.; Watson, D.; White, A.; Yang, C.
Journal Article
2012OpenTox predictive toxicology framework
Tcheremenskaia, Olga; Benigni, Romualdo; Nikolova, Ivelina; Jeliazkova, Nina; Escher, Sylvia E.; Batke, Monika; Baier, Thomas; Poroikov, Vladimir; Lagunin, Alexey; Rautenberg, Micha; Hardy, Barry
Journal Article
2012Toxicology ontology perspectives
Hardy, B.; Apic, G.; Carthew, P.; Clark, D.; Cook, D.; Dix, I.; Escher, S.; Hastings, J.; Heard, D.J.; Jeliazkova, N.; Judson, P.; Matis-Mitchell, S.; Mitic, D.; Myatt, G.; Shah, I.; Spjuth, O.; Tcheremenskaia, O.; Toldo, L.; Watson, D.; White, A.; Yang, C.
Journal Article
2011Evaluation of time extrapolation factors based on the database RepDose
Batke, M.; Escher, S.; Hoffmann-Doerr, S.; Melber, C.; Messinger, H.; Mangelsdorf, I.
Journal Article
2011Improvement of the Cramer classification for oral exposure using the database TTC RepDose - A strategy description
Tluczkiewicz, I.; Buist, H.E.; Martin, M.T.; Mangelsdorf, I.; Escher, S.E.
Journal Article
2010CCR1- and CCR5-mediated inactivation of leukocytes by a nonglycosaminoglycan (non-GAG)-binding variant of n-Nonanoyl-CCL14 (NNY-CCL14)
Gupta, S.; Rieder, S.; Richter, R.; Schulz-Maronde, S.; Manns, J.; Escher, S.E.; Heitland, A.; Mack, M.; Forssmann, W.-G.; Elsner, J.; Forssmann, U.
Journal Article
2010Collaborative development of predictive toxicology applications
Hardy, B.; Douglas, N.; Helma, C.; Rautenberg, M.; Jeliazkova, N.; Jeliazkov, V.; Nikolova, I.; Benigni, R.; Tcheremenskaia, O.; Kramer, S.; Girschick, T.; Buchwald, F.; Wicker, J.; Karwath, A.; Gütlein, M.; Maunz, A.; Sarimveis, H.; Melagraki, G.; Afantitis, A.; Sopasakis, P.; Gallagher, D.; Poroikov, V.; Filimonov, D.; Zakharov, A.; Lagunin, A.; Gloriozova, T.; Novikov, S.; Skvortsova, N.; Druzhilovsky, D.; Chawla, S.; Ghosh, I.; Ray, S.; Patel, H.; Escher, S.
Journal Article
2010Data quality assessment for ini silico methods: A survey of approaches and needs
Nendza, M.; Aldenberg, T.; Benfenati, E.; Benigni, R.; Cronin, M.T.D.; Escher, S.; Fernandez, A.; Gabbert, S.; Giralt, F.; Hewitt, M.; Hrovat, M.; Jeram, S.; Kroese, D.; Madden, J.C.; Mangelsdorf, I.; Rallo, R.; Roncaglioni, A.; Rorije, E.; Segner, H.; Simon-Hettich, B.; Vermeire, T.G.
Book Article
2010Evaluation of inhalation TTC values with the database RepDose
Escher, S.E.; Tluczkiewicz, I.; Batke, M.; Bitsch, A.; Melber, C.; Kroese, E.D.; Buist, H.E.; Mangelsdorf, I.
Journal Article
2010Exposure-based waiving under REACH
Vermeire, T.; Bovenkamp, M. von de; Bruin, Y.B. de; Delmaar, C.; Engelen, J. van; Escher, S.; Marquart, H.; Meijster, T.
Journal Article
2010Use of combined databases RepDose (FhG), Toxbase (TNO), MunroDB and ToxRefDB (USEPA) to refine TTCs for oral exposure
Tluczkiewicz, I.; Mangelsdorf, I.; Buist, H.; Martin, M.; Escher, S.
Conference Paper, Journal Article
2009Analysis of target organs in repeated dose toxicity studies
Escher, S.; Batke, M.; Bitsch, A.; Licht, O.; Melber, C.; Simetska, N.; Mangelsdorf, I.
Abstract
2009Applicability domain of TTC (Threshold of Toxicological Concern) schemes - a conceptual approach
Schüürmann, G.; Ebert, R.-U.; Escher, S.; Mangelsdorf, I.; Kühne, R.
Abstract
2009Evaluation of risk assessment factors for inter-species and time-extrapolation
Escher, S.; Mangelsdorf, I.
Abstract
2009Evaluation of the TTC concept with the database RepDose
Escher, S.; Mangelsdorf, I.
Abstract
2009How valid are "old" repeated dose toxicity studies for chemical risk assessment?
Batke, M.; Escher, S.; Bitsch, A.; Melber, C.; Simetska, N.; Mangelsdorf, I.
Abstract
2009How valid are old repeated dose toxicity studies for chemical risk assessment?
Mangelsdorf, I.; Batke, M.; Escher, S.
Abstract
2009Refinement of TTC values: Identification of outliers in Cramer class 1-3
Tluczkiewicz, I.; Escher, S.; Bitsch, A.; Mangelsdorf, I.
Abstract
2009Sound oral to inhalation extrapolation factors for human health risk assessment
Escher, S.; Mangelsdorf, I.
Abstract
2009Toxicological categories - A necessary extension of the chemical category approach
Weiss, S.; Escher, S.; Bitsch, A.; Mangelsdorf, I.
Abstract
2008Breath - a database on occupational exposure limits and local irritation
Batke, M.; Escher, S.; Bitsch, A.; Melber, C.; Simetska, N.; Konieczko, K.; Czerczak, S.; Mangelsdorf, I.
Abstract
2008Influence of study parameters on TTC
Escher, S.; Bitsch, A.; Batke, M.; Melber, C.; Simetska, N.; Mangelsdorf, I.
Conference Paper, Journal Article
2008Intravascular inactivation of CCR5 by n-Nonanoyl-CC chemokine ligand 14 and inhibition of allergic airway inflammation
Gupta, S.; Fuchs, B.; Schulz-Maronde, S.; Heitland, A.; Escher, S.E.; Mack, M.; Tillmann, H.C.; Braun, A.; Forssmann, W.G.; Elsner, J.; Forssmann, U.
Journal Article
2008RepDose and FeDTex. Two databases focusing on systemic toxicity
Bitsch, A.; Escher, S.; Lewin, G.; Melber, C.; Simetska, N.; Mangelsdorf, I.
Conference Paper, Journal Article
2007Inhibition of airway inflammation and HIV entry by NNY-CCL14 treatment: Role of CCR1 and CCR5
Gupta, S.; Fuchs, B.; Schulz-Maronde, S.; Heitland, A.; Escher, S.E.; Münch, J.; Kirchhoff, F.; Mack, M.; Tillmann, H.C.; Braun, A.; Forssmann, W.G.; Forssmann, U.; Elsner, J.
Conference Paper, Journal Article
2006The allergy-associated chemokine receptors CCR3 and CCR5 can be inactivated by the modified chemokine NNY-CCL11
Manns, J.; Rieder, S.; Escher, S.; Eilers, B.; Forssmann, W.-G.; Elsner, J.; Forssmann, U.
Journal Article
2004n-Nonanoyl-CC chemokine ligand 14, a potent CC chemokine ligand 14 analogue that prevents the recruitment of eosinophils in allergic airway inflammation
Forssmann, U.; Hartung, I.; Bälder, R.; Fuchs, B.; Escher, S.E.; Spodsberg, N.; Dulkys, Y.; Walden, M.; Heitland, A.; Braun, A.; Forssmann, W.-G.; Elsner, J.
Journal Article