Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar, Z.; Östling, J.; Ax, E.; Calven, J.; Thörn, K.; Israelsson, E.; Öberg, L.; Singhania, A.; Lau, L.C.K.; Wilson, S.J.; Ward, J.A.; Chauhan, A.; Sousa, A.R.; Meulder, B. de; Loza, M.J.; Baribaud, F.; Sterk, P.J.; Chung, K.F.; Sun, K.; Guo, Y.; Adcock, I.M.; Payne, D.; Dahlen, B.; Chanez, P.; Shaw, D.E.; Krug, Norbert; Hohlfeld, Jens M.; Sandström, T.; Djukanovic, R.; James, A.; Hinks, T.S.C.; Howarth, P.H.; Vaarala, O.; Geest, M. van; Olsson, H.; Adcock, I.M.; Ahmed, H.; Auffray, C.; Bakke, P.; Bansal, A.T.; Baribaud, F.; Bates, S.; Bel, E.H.; Bigler, J.; Bisgaard, H.; Boedigheimer, M.J.; Bonnelykke, K.; Brandsma, J.; Brinkman, P.; Bucchioni, E.; Burg, D.; Bush, A.; Caruso, M.; Chaiboonchoe, A.; Chanez, P.; Chung, F.K.; Compton, C.H.; Corfield, J.; D'Amico, A.; Dahlen, S.E.; De Meulder, B.; Djukanovic, R.; Erpenbeck, V.J.; Erzen, D.; Fichtner, K.; Fitch, N.; Fleming, L.J.; Formaggio, E.; Fowler, S.J.; Frey, U.; Gahlemann, M.; Geiser, T.; Goss, V.; Guo, Y.; Hashimoto, S.; Haughney, J.; Hedlin,
Journal Article
2015Controlled exposure to grass pollen in an environmental challenge chamber induces a worsening of cutaneous symptoms in patients with atopic dermatitis
Heratizadeh, A.; Badorrek, P.; Kapp, A.; Niebuhr, M.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Loesche, C.; Jung, T.; Krug, N.; Hohlfeld, J.M.; Werfel, T.
Abstract
2015Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
Werfel, T.; Heratizadeh, A.; Niebuhr, M.; Kapp, A.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Lösche, C.; Jung, T.; Krug, N.; Badorrek, P.; Hohlfeld, J.M.
Journal Article
2011Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
Winkler, C.; Atochina-Vasserman, E.N.; Holz, O.; Beers, M.F.; Erpenbeck, V.J.; Krug, N.; Roepcke, S.; Lauer, G.; Elmlinger, M.; Hohlfeld, J.M.
Journal Article
2010Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
Schleh, C.; Erpenbeck, V.J.; Winkler, C.; Lauenstein, H.D.; Nassimi, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2010Surfactant protein D modulates pulmonary clearance of pollen starch granules
Winkler, C.; Hüper, K.; Wedekind, A-C.; Rochlitzer, S.; Hartwig, C.; Müller, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.; Erpenbeck, V.J.
Journal Article
2009The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure
Schleh, C.; Mühlfeld, C.; Pulskamp, K.; Schmiedl, S.; Nassimi, M.; Lauenstein, H.D.; Braun, A.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Journal Article
2009Die Interaktion zwischen pulmonalem Surfactant und inhalierbaren Partikeln
Schleh, C.
: Ngezahayo, A.; Erpenbeck, V.J.
Dissertation
2009Therapeutic surfactants modulate the viability of Eosinophils and induce inflammatory mediator release
Erpenbeck, V.J.; Fischer, I.; Wiese, K.; Schaumann, F.; Schmiedl, A.; Nassenstein, C.; Krug, N.; Hohlfeld, J.M.
Journal Article
2009Therapeutic use of surfactant components in allergic asthma
Erpenbeck, V.J.; Krug, N.; Hohlfeld, J.M.
Journal Article
2008Engineered nanoparticles induce a pulmonary surfactant dysfunction after surface area cycling in vitro
Schleh, C.; Nassimi, M.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Conference Paper
2007Effect of nanosized particles on pulmonary surfactant function
Schleh, C.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Conference Paper, Journal Article
2006Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
Thum, T.; Erpenbeck, V.J.; Moeller, J.; Hohlfeld, J.M.; Krug, N.; Borlak, J.
Journal Article
2006Lung fibroblasts from patients with emphysema show markers of senescence in vitro
Müller, K.C.; Welker, L.; Paasch, K.; Feindt, B.; Erpenbeck, V.J.; Hohlfeld, J.M.; Krug, N.; Nakashima, M.; Branscheid, D.; Magnussen, H.; Jörres, R.A.; Holz, O.
Journal Article
2006Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma
Nassenstein, C.; Dawbarn, D.; Pollock, K.; Allen, S.J.; Erpenbeck, V.J.; Spies, E.; Krug, N.; Braun, A.
Journal Article
2006Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge
Erpenbeck, V.J.; Hagenberg, A.; Krentel, H.; Discher, M.; Braun, A.; Hohlfeld, J.M.; Krug, N.
Journal Article
2006Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice
Erpenbeck, V.J.; Ziegert, M.; Cavalet-Blanco, D.; Martin, C.; Bälder, R.; Glaab, T.; Braun, A.; Steinhilber, W.; Luettig, B.; Uhlig, S.; Hoymann, H.G.; Krug, N.; Hohlfeld, J.M.
Journal Article
2006Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma
Erpenbeck, V.J.; Schmidt, R.; Gunther, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2005beta2-Adrenoceptor-mediated suppression of human intestinal mast cell functions is caused by disruption of filamentous actin dynamics
Gebhardt, T.; Gerhard, R.; Bedoui, S.; Erpenbeck, V.J.; Hoffmann, M.W.; Manns, M.P.; Bischoff, S.C.
Journal Article
2005The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S.
Journal Article
2005The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Lehr, H.A.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S.
Journal Article
2005Local nitric oxide levels reflect the degree of allergic airway inflammation after segmental allergen challenge in asthmatics
Erpenbeck, V.J.; Jörres, R.A.; Discher, M.; Luettig, B.; Krug, N.; Hohlfeld, J.M.
Journal Article
2005Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules
Erpenbeck, V.J.; Malherbe, D.C.; Sommer, S.; Schmiedl, A.; Steinhilber, W.; Ghio, A.J.; Krug, N.; Wright, J.R.; Hohlfeld, J.M.
Journal Article
2004Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma
Hohlfeld, J.M.; Schmiedl, A.; Erpenbeck, V.J.; Venge, P.; Krug, N.
Journal Article
2004Natural porcine surfactant augments airway inflammation after allergen challenge in patients with asthma
Erpenbeck, V.J.; Hagenberg, A.; Dulkys, Y.; Elsner, J.; Balder, R.; Krentel, H.; Discher, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2003Divergence in urinary 8-iso-PGF[2alpha] (iPF[2alpha],-III, 15-F2t-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF[2alpha]
Tsikas, D.; Schwedhelm, E.; Suchy, M.-T.; Niemann, J.; Gutzki, F.-M.; Erpenbeck, V.J.; Hohlfeld, J.M.; Surdacki, A.; Frölich, J.C.
Journal Article
2003Increased expression of interleukin-9 messenger RNA after segmental allergen challenge in allergic asthmatics
Erpenbeck, V.J.; Hohlfeld, J.M.; Discher, M.; Krentel, H.; Hagenberg, A.; Braun, A.; Krug, N.
Journal Article, Conference Paper
2003Local release of eosinophil peroxidase following segmental allergen provocation in asthma
Erpenbeck, V.J.; Hohlfeld, J.M.; Petschallies, J.; Eklund, E.; Peterson, C.G.B.; Fabel, H.; Krug, N.
Journal Article
2003The neurotrophins nerve growth factor, brain-derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 are survival and activation factors for Eosinophils in patients with allergic bronchial asthma
Nassenstein, C.; Braun, A.; Erpenbeck, V.J.; Lommatzsch, M.; Schmidt, S.; Krug, N.; Luttmann, W.; Renz, H.; Virchow, J.C.
Journal Article
2003Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes
Erpenbeck, V.J.; Hohlfeld, J.M.; Volkmann, B.; Hagenberg, A.; Geldmacher, H.; Braun, A.; Krug, N.
Journal Article
2003Surfactant proteins SP-A and SP-D as modulators of the allergic inflammation in asthma
Hohlfeld, J.M.; Erpenbeck, V.J.; Krug, N.
Conference Paper, Journal Article
2001Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma
Krug, N.; Tschernig, T.; Erpenbeck, V.J.; Hohlfeld, J.M.; Köhl, J.
Journal Article
2001Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gamma delta T cells in people with asthma after segmental allergen challenge
Krug, N.; Erpenbeck, V.J.; Balke, K.; Petschallies, J.; Tschernig, T.; Hohlfeld, J.M.; Fabel, H.
Journal Article
2001Die Expression von T-Zell-Zytokinen bei Patienten mit allergischem Asthma nach segmentaler Allergenprovokation
Erpenbeck, V.J.
: Freihorst, J. (Prüfer); Kleine, P. (Prüfer); Fabel, H. (Prüfer); Krug, N. (Prüfer)
Dissertation
2000Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma
Krug, N.; Cruikshank, W.W.; Tschernig, T.; Erpenbeck, V.J.; Balke, K.; Hohlfeld, J.M.; Center, D.M.; Fabel, H.
Journal Article
1999Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Enhorning, G.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.-G.; Fabel, H.; Krug, N.
Journal Article
1998Pulmonary surfactant function is impaired in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H.
Journal Article
1998Störung der Surfactantfunktion bei Asthmatikern nach segmentaler Allergenprovokation
Hohlfeld, J.M.; Ahlf, K.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H.
Journal Article