Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2016Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins
Arfi, Z.A.; Hellwig, S.; Drossard, J.; Fischer, R.; Buyel, J.F.
Journal Article
2016Production, quality control, stability and pharmacotoxicity of a malaria vaccine comprising three highly similar PfAMA1 protein molecules to overcome antigenic variation
Faber, B.W.; Hellwig, S.; Houard, S.; Havelange, N.; Drossard, J.; Mertens, H.; Croon, A.; Kastilan, R.; Byrne, R.; Werff, N. van der; Eijk, M. van der; Thomas, A.W.; Kocken, C.H.M.; Remarque, E.J.
Journal Article
2015From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants
Sack, M.; Rademacher, T.; Spiegel, H.; Boes, A.; Hellwig, S.; Drossard, J.; Stoger, E.; Fischer, R.
Journal Article
2015Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants
Ma, J.K.-C.; Drossard, J.; Lewis, D.; Altmann, F.; Boyle, J.; Christou, P.; Cole, T.; Dale, P.; Dolleweerd, C.J. van; Isitt, V.; Katinger, D.; Lobedan, M.; Mertens, H.; Paul, M.J.; Rademacher, T.; Sack, M.; Hundleby, P.A.C.; Stiegler, G.; Stoger, E.; Twyman, R.M.; Vcelar, B.; Fischer, R.
Journal Article
2014Molecular Farming: Innovative Produktion pharmazeutischer Proteine in Pflanzen
Buyel, J.F.; Reimann, A.; Drossard, J.; Fischer, R.
Journal Article
2012GMP issues for recombinant plant-derived pharmaceutical proteins
Fischer, R.; Schillberg, S.; Hellwig, S.; Twyman, R.M.; Drossard, J.
Journal Article
2008Modulation of polyamine biosynthesis in transformed tobacco plants by targeting ornithine decarboxylase to an atypical subcellular compartment
Nölke, G.; Schneider, B.; Agdour, S.; Drossard, J.; Fischer, R.; Schillberg, S.
Journal Article
2008New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants
Platis, D.; Drossard, J.; Fischer, R.; Ma, J.K.-C.; Labrou, N.E.
Journal Article
2007Facing the future with pharmaceuticals from plants
Fischer, R.; Twyman, R.M.; Hellwig, S.; Drossard, J.; Schillberg, S.
Conference Paper
2005Plant cells
Fischer, R.; Twyman, R.M.; Drossard, J.; Hellwig, S.; Schillberg, S.
Book Article
2004Plant cell cultures for the production of recombinant proteins
Hellwig, S.; Drossard, J.; Twyman, R.M.; Fischer, R.
Journal Article
2003Using plants as a production system for N-Glycosylated proteins of therapeutic relevance
Hellwig, S.; Sack, M.; Spiegel, H.; Drossard, J.; Fischer, R.
Journal Article
2002A carcinoembryonic antigen-specific diabody produced in tobacco
Vaquero, C.; Sack, M.; Schuster, F.; Finnern, R.; Drossard, J.; Schumann, D.; Reimann, A.; Fischer, R.
Journal Article
2000Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies
Stöger, E.; Vaquero, C.; Torres, E.; Sack, M.; Nicholson, L.; Drossard, J.; Williams, S.; Keen, D.; Perrin, Y.; Christou, P.; Fischer, R.
Journal Article
2000Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy
Perrin, Y.; Vaquero, C.; Gerrard, I.; Sack, M.; Drossard, J.; Stöger, E.; Christou, P.; Fischer, R.
Journal Article
2000Yeast and plant cells as biofactories for recombinant proteins. Evaluation of novel expression and downstream processing strategies
Drossard, J.
Dissertation
1999Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture
Fischer, R.; Liao, Y.C.; Drossard, J.
Journal Article
1999Engineering and expression of bispecific single chain Fv fragments in transgenic tobacco plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Production of carcinoembryonic antigen (CEA) N-A3 domain in Pichia pastoris by fermentation
Hellwig, S.; Robin, F.; Drossard, J.; Raven, N.P.G.; Vaquero-Martin, C.; Shively, J.E.; Fischer, R.
Journal Article
1999Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies
Torres, E.; Vaquero, C.; Nicholson, L.; Sack, M.; Stöger, E.; Drossard, J.; Christou, P.; Fischer, R.; Perrin, Y.
Journal Article
1999Towards molecular farming in the future: moving from diagnostic protein and antibody production in microbes to plants
Fischer, R.; Drossard, J.; Commandeur, U.; Schillberg, S.; Emans, N.
Journal Article
1999Towards molecular farming in the future: Pichia pastoris-based production of single-chain antibody fragments
Fischer, R.; Drossard, J.; Emans, N.; Commandeur, U.; Hellwig, S.
Journal Article
1999Towards molecular farming in the future: transient protein expression in plants
Fischer, R.; Vaquero-Martin, C.; Sack, M.; Drossard, J.; Emans, N.; Commandeur, U.
Journal Article
1999Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors
Fischer, R.; Emans, N.; Schuster, F.; Hellwig, S.; Drossard, J.
Journal Article
1999Transgenic plants as bioreactors for the expression of recombinant antibodies and their downstream processing
Fischer, R.; Hellwig, S.; Drossard, J.; Emans, N.; Schillberg, S.
Conference Paper
1999Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves
Vaquero, C.; Sack, M.; Chandler, J.; Drossard, J.; Schuster, F.; Monecke, M.; Schillberg, S.; Fischer, R.
Journal Article
1998Transgenic plants as bioreactors for the expression of recombinant antibodies
Fischer, R.; Drossard, J.; Hellwig, S.; Emans, N.; Schillberg, S.
Conference Paper
1997Production of engineered antibodies in tobacco plants and cell suspension cultures
Drossard, J.; Nähring, J.M.; Hellwig, S.; Fischer, R.
Conference Paper