Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer's disease
Hartlage-Rübsamen, Maike; Ratz, Veronika; Zeitschel, Ulrike; Finzel, Lukas; Machner, Lisa; Köppen, Janett; Schulze, Anja; Demuth, Hans-Ulrich; Hörsten, Stephan von; Höfling, Corinna; Roßner, Steffen
Journal Article
2018Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice
Dunkelmann, Tina; Teichmann, Kerstin; Ziehm, Tamar; Schemmert, Sarah; Frenzel, Daniel; Tusche, Markus; Dammers, Christina; Jürgens, Dagmar; Langen, Karl-Josef; Demuth, Hans-Ulrich; Shah, Nadim Jon; Kutzsche, Janine; Willuweit, Antje; Willbold, Dieter
Journal Article
2018Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
Schulze, Anja; Wermann, Michael; Demuth, Hans-Ulrich; Yoshimoto, Tadashi; Ramsbeck, Daniel; Schlenzig, Dagmar; Schilling, Stephan
Journal Article
2018Dipeptidyl-peptidase activity of meprin β links N-truncation of Aβ with glutaminyl cyclase-catalyzed pGlu-Aβ formation
Schlenzig, Dagmar; Cynis, Holger; Hartlage-Rübsamen, Maike; Zeitschel, Ulrike; Menge, Katja; Fothe, Anja; Ramsbeck, Daniel; Spahn, Claudia; Wermann, Michael; Roßner, Steffen; Buchholz, Mirko; Schilling, Stephan; Demuth, Hans-Ulrich
Journal Article
2018Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-abeta formation
Hartlage-Rübsamen, Maike; Bluhm, Alexandra; Piechotta, Anke; Linnert, Miriam; Rahfeld, Jens-Ulrich; Demuth, Hans-Ulrich; Lues, Inge; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F.; Roßner, Steffen; Höfling, Corinna
Journal Article
2017Posttranslational modification impact on the mechanism by which amyloid‐β induces synaptic dysfunction
Grochowska, Katarzyna M.; Yuanxiang, PingAn; Bär, Julia; Raman, Rajeev; Brugal, Gemma; Sahu, Giriraj; Schweizer, Michaela; Bikbaev, Arthur; Schilling, Stephan; Demuth, Hans-Ulrich; Kreutz, Michael R.
Journal Article
2017Recent progress in translational research on neurovascular and neurodegenerative disorders
Demuth, Hans-Ulrich; Dijkhuizen, Rick M.; Farr, Tracy D.; Gelderblom, Mathias; Horsburgh, Karen; Iadecola, Costantino; Mcleod, Damian D.; Michalski, Dominik; Murphy, Tim H.; Orbe, Josune; Otte, Wilem M.; Petzold, Gabor C.; Plesnila, Nikolaus; Reiser, Georg; Reymann, Klaus G.; Rueger, Maria P.; Saur, Dorothee; Savitz, Sean; Schilling, Stephan; Spratt, Neil J.; Turner, Renée J.; Vermuganti, Raghu; Vivien, Denis; Yepes, Manuel; Zille, Marietta; Boltze, Johannes
Journal Article
2016Enhanced fibril fragmentation of N-terminally truncated and Pyroglutamyl-modified Aβ peptides
Wulff, Melanie; Baumann, Monika; Thümmler, Anka; Yadav, Jay K.; Heinrich, Liesa; Knüpfer, Uwe; Schlenzig, Dagmar; Schierhorn, Angelika; Rahfeld, Jens-Ulrich; Horn, Uwe; Balbach, Jochen; Demuth, Hans-Ulrich; Fändrich, Marcus
Journal Article
2016Natural products from microalgae with potential against Alzheimer´s disease
Hielscher-Michael, Stephanie; Griehl, Carola; Buchholz, Mirko; Demuth, Hans-Ulrich; Arnold, Norbert; Wessjohann, Ludger A.
Journal Article
2016Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1–30 fragment
Wagner, Leona; Björkqvist, Maria; Lundh, Sofia Hult; Wolf, Raik; Börgel, Arne; Schlenzig, Dagmar; Ludwig, Hans-Henning; Rahfeld, Jens-Ulrich; Leavitt, Blair R.; Demuth, Hans-Ulrich; Petersén, Åsa; Hörsten, Stephan von
Journal Article
2015An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice
Frost, Jeffrey L.; Liu, Bin; Rahfeld, Jens-Ulrich; Kleinschmidt, Martin; O'Nuallain, Brian; Le, Kevin X.; Lues, Inge; Caldarone, Babara J.; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A.
Journal Article
2015Characterizing aging, mild cognitive impairment, and dementia with blood-based biomarkers and neuropsychology
Kleinschmidt, Martin; Schoenfeld, Robby; Göttlich, Claudia; Bittner, Daniel; Metzner, Jürgen Erich; Leplow, Bernd; Demuth, Hans-Ulrich
Journal Article
2015Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes
Waniek, Alexander; Hartlage-Rübsamen, Maike; Höfling, Corinna; Kehlen, Astrid; Schilling, Stephan; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2015Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease
Hartlage-Rübsamen, Maike; Waniek, Alexander; Meißner, Juliane; Morawski, Markus; Schilling, Stephan; Jäger, Carsten; Kleinschmidt, Martin; Cynis, Holger; Kehlen, Astrid; Arendt, Thomas; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2015The proteolytic profile of human cancer procoagulant suggests that it promotes cancer metastasis at the level of activation rather than degradation
Kee, Nalise Low Ah; Krause, Jason; Blatch, Gregory L.; Muramoto, Koji; Sakka, Kazuo; Sakka, Makiko; Naudé, Ryno J.; Wagner, Leona; Wolf, Raik; Rahfeld, Jens-Ulrich; Demuth, Hans-Ulrich; Mielicki, Wojciech P.; Frost, Carminita L.
Journal Article
2015Purification and characterization of recombinant N-terminally pyroglutamate-modified amyloid-beta variants and structural analysis by solution NMR spectroscopy
Dammers, Christina; Gremer, Lothar; Neudecker, Philipp; Demuth, Hans-Ulrich; Schwarten, Melanie; Willbold, Dieter
Journal Article
2015QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; Groen, Thomas van; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne A.; Nagel-Steger, Luitgard; Willbold, Dieter
Journal Article
2015Structural analysis and aggregation propensity of pyroglutamate Aβ(3-40) in aqueous trifluoroethanol
Dammers, Christina; Gremer, Lothar; Reiß, Kerstin; Klein, Antonia N.; Neudecker, Philipp; Hartmann, Rudolph; Sun, Na; Demuth, Hans-Ulrich; Schwarten, Melanie; Willbold, Dieter
Journal Article
2014Glutaminyl cyclase in human cortex: Correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease
Morawski, Markus; Schilling, Stephan; Kreuzberger, Moritz; Waniek, Alexander; Jäger, Carsten; Koch, Birgit; Cynis, Holger; Kehlen, Astrid; Arendt, Thomas; Hartlage-Rübsamen, Maike; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2014Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC
Höfling, Corinna; Indrischek, Henrike; Höpcke, Theodor; Waniek, Alexander; Cynis, Holger; Koch, Birgit; Schilling, Stephan; Morawski, Markus; Demuth, Hans-Ulrich; Roßner, Steffen; Hartlage-Rübsamen, Maike
Journal Article
2014A non-canonical function of eukaryotic elongation factor 1A1: Regulation of interleukin-6 expression
Schulz, Ingo; Engel, Claudia; Niestroj, André J.; Kehlen, Astrid; Rahfeld, Jens-Ulrich; Kleinschmidt, Martin; Lehmann, Karola; Roßner, Steffen; Demuth, Hans-Ulrich
Journal Article
2014Pyroglutamate-Amyloid-β and Glutaminyl Cyclase are Colocalized with Amyloid-β in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion
Cynis, Holger; Funkelstein, Lydiane; Toneff, T.; Mosier, C.; Ziegler, M.; Koch, Birgit; Demuth, Hans-Ulrich; Hook, V.
Journal Article
2013Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration
Becker, Andreas; Kohlmann, Stephanie; Alexandru, Anca; Jagla, Wolfgang; Canneva, Fabio; Bäuscher, Christoph; Cynis, Holger; Sedlmeier, Reinhard; Graubner, Sigrid; Schilling, Stephan; Demuth, Hans-Ulrich; Hörsten, Stephan von
Journal Article
2013Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice
Cynis, Holger; Kehlen, Astrid; Haegele, Monique; Hoffmann, Torsten; Heiser, Ulrich; Fujii, Masato; Shibazaki, Yuichiro; Yoneyama, Hiroyuki; Schilling, Stephan; Demuth, Hans-Ulrich
Journal Article
2013Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease–like transgenic mouse models
Frost, Jeffrey L.; Le, Kevin X.; Cynis, H.; Ekpo, Elisabeth; Kleinschmidt, Martin; Palmour, Roberta M.; Ervin, Frank R.; Snigdha, Shikha; Cotman, Carl W.; Saido, Takaomi C.; Vassar, Robert J.; George-Hyslop, Peter S.; Ikezu, Tsuneya; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A.
Journal Article
2012Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy
Sun, Na; Hartmann, Rudolf; Lecher, Justin; Stoldt, Matthias; Funke, Susanne Aileen; Gremer, Lothar; Ludwig, Hans-Henning; Demuth, Hans-Ulrich; Kleinschmidt, Martin; Willbold, Dieter
Journal Article