Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice
Dunkelmann, T.; Schemmert, S.; Honold, D.; Teichmann, K.; Butzküven, E.; Demuth, H.-U.; Shah, N.J.; Langen, K.-J.; Kutzsche, J.; Willbold, D.; Willuweit, A.
Journal Article
2018Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro
Antonyan, A.; Schlenzig, D.; Schilling, S.; Naumann, M.; Sharoyan, S.; Mardanyan, S.; Demuth, H.-U.
Journal Article
2018Kallikrein‐related peptidases are activators of the CC chemokine CCL14
Grünberg, M.; Quandt, D.; Cynis, H.; Demuth, H.-U.; Kindermann, A.; Magdolen, V.; Forssmann, W.-G.; Seliger, B.; Mägert, H.-J.
Journal Article
2017Glutaminyl cyclase inhibitor PQ912 improves cognition in mouse models of Alzheimer's disease - studies on relation to effective target occupancy
Hoffmann, T.; Meyer, A.; Heiser, U.; Kurat, S.; Böhme, L.; Kleinschmidt, M.; Bühring, K.-U.; Hutter-Paier, B.; Farcher, M.; Demuth, H.-U.; Lues, I.; Schilling, S.
Journal Article
2017N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity
Kehlen, A.; Haegele, M.; Böhme, L.; Cynis, H.; Hoffmann, T.; Demuth, H.-U.
Journal Article
2016Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation
Wagner, L.; Kaestner, F.; Wolf, R.; Stiller, H.; Heiser, U.; Manhart, S.; Hoffmann, T.; Rahfeld, J.-U.; Demuth, H.-U.; Rothermundt, M.; Hörsten, S. von
Journal Article
2016The pyroglutamate modification of toxic Aβ resulted new therapeutic aproaches: Inhibitors of glutaminyl cyclase and highly specific antibodies - a status report
Demuth, H.-U.; Schilling, S.; Lues, I.
Abstract
2015Proteolytic degradation of neuropeptide Y (NPY) from head to toe
Wagner, L.; Wolf, R.; Zeitschel, U.; Rossner, S.; Petersén, A.; Leavitt, B.R.; Kästner, F.; Rothermundt, M.; Gärtner, U.-T.; Gündel, D.; Schlenzig, D.; Frerker, N.; Schade, J.; Manhart, S.; Rahfeld, J.-U.; Demuth, H.-U.; Hörsten, S. von
Journal Article
2014Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death
Lison, H.; Happel, M.F.K.; Schneider, F.; Baldauf, K.; Kerbstat, S.; Seelbinder, B.; Schneeberg, J.; Zappe, M.; Goldschmidt, J.; Budinger, E.; Schröder, U.H.; Ohl, F.W.; Schilling, S.; Demuth, H.-U.; Scheich, H.; Reymann, K.G.; Rönicke, R.
Journal Article
2014Prämorbides Intelligenzniveau als Reservefunktion bei neurokognitiven Störungen des Alters
Schönfeld, R.; Kleinschmidt, M.; Demuth, H.-U.; Metzner, J.; Bittner, D.; Leplow, B.
Abstract
2013Glutaminyl cyclases
Cynis, H.; Schilling, S.; Demuth, H.-U.
Book Article
2013Glutaminyl cyclases as novel targets for the treatment of septic arthritis
Hellvard, A.; Maresz, K.; Schilling, S.; Graubner, S.; Heiser, U.; Jonsson, R.; Cynis, H.; Demuth, H.-U.; Potempa, J.; Mydel, P.
Journal Article
2013Proteases in the nervous system
Cynis, H.; Lichtenthaler, S.F.; Wagner, L.; Demuth, H.-U.
Book Article
2013Role of glutaminyl cyclases in thyroid carcinomas
Kehlen, A.; Haegele, M.; Menge, K.; Gans, K.; Immel, U.-D.; Hoang-Vu, C.; Klonisch, T.; Demuth, H.-U.
Journal Article
2013Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4
Kolenko, P.; Koch, B.; Rahfeld, J.-U.; Schilling, S.; Demuth, H.-U.; Stubbs, M.T.
Journal Article
2013Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold
Ramsbeck, D.; Buchholz, M.; Koch, B.; Böhme, L.; Hoffmann, T.; Demuth, H.-U.; Heiser, U.
Journal Article