Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020Antifibrotic effects of amyloid-beta and its loss in cirrhotic liver
Buniatian, Gayane Hrachia; Weiskirchen, Ralf; Weiss, Thomas S.; Schwinghammer, Ute; Fritz, Martin; Seferyan, Torgom; Proksch, Barbara; Glaser, Michael; Lourhmati, Ali; Buadze, Marine; Borkham-Kamphorst, Erawan; Gaunitz, Frank; Gleiter, Christoph H.; Lang, Thomas; Schaeffeler, Elke; Tremmel, Roman; Cynis, Holger; Frey II, William H.; Gebhardt, Rolf; Friedmann, Scott L.; Mikulits, Wolfgang; Schwab, Matthias; Danielyan, Lusine
Journal Article
2019Identification of human endogenous retrovirus transcripts in Hodgkin Lymphoma cells
Barth, Marie; Gröger, Victoria; Cynis, Holger; Staege, Martin Sebastian
Journal Article
2019Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity
Lienau, Claudia; Gräwert, Tobias; Alves Avelar, Leandro A.; Illarionov, Boris; Held, Jana; Knaab, Tanja C.; Lungerich, Beate; Geelen, Lasse van; Meier, Dieter; Geißler, Stefanie; Cynis, Holger; Riederer, Ulrich; Buchholz, Mirko; Kalscheuer, Rainer; Bacher, Adelbert; Mordmüller, Benjamin; Fischer, Markus; Kurz, Thomas
Journal Article
2018Dipeptidyl-peptidase activity of meprin β links N-truncation of Aβ with glutaminyl cyclase-catalyzed pGlu-Aβ formation
Schlenzig, Dagmar; Cynis, Holger; Hartlage-Rübsamen, Maike; Zeitschel, Ulrike; Menge, Katja; Fothe, Anja; Ramsbeck, Daniel; Spahn, Claudia; Wermann, Michael; Roßner, Steffen; Buchholz, Mirko; Schilling, Stephan; Demuth, Hans-Ulrich
Journal Article
2018Human endogenous retroviruses and their putative role in the development of autoimmune disorders such as multiple sclerosis
Gröger, Victoria; Cynis, Holger
Journal Article
2018Structure-guided design, synthesis, and characterization of next-generation meprin β inhibitors
Ramsbeck, Daniel; Hamann, Antje; Richter, Georg; Schlenzig, Dagmar; Geißler, Stefanie; Nykiel, Vera; Cynis, Holger; Schilling, Stephan; Buchholz, Mirko
Journal Article
2016Immunotherapy targeting pyroglutamate-3 Aβ
Cynis, Holger; Frost, Jeffrey L.; Crehan, Helen; Lemere, Cynthia A.
Journal Article
2015Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease
Hartlage-Rübsamen, Maike; Waniek, Alexander; Meißner, Juliane; Morawski, Markus; Schilling, Stephan; Jäger, Carsten; Kleinschmidt, Martin; Cynis, Holger; Kehlen, Astrid; Arendt, Thomas; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2015Isolation und Kultivierung von Mikrogliazellen aus murinen Hirngewebe und deren Stimulation zur Generierung eines ruhenden adulten Phänotyps
Hietel, Benjamin
: Stohwasser, Ralf (Gutachter); Cynis, Holger (Gutachter)
Bachelor Thesis
2015Klonierung, Expression und Reinigung von Hüllproteinen Humaner Endogener Retroviren als Zielproteine in der Multiple Sklerose-Forschung
Zhang, Ziyun
: Mägert, Hans-Jürgen (Gutachter); Cynis, Holger (Gutachter)
Master Thesis
2014Glutaminyl cyclase in human cortex: Correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease
Morawski, Markus; Schilling, Stephan; Kreuzberger, Moritz; Waniek, Alexander; Jäger, Carsten; Koch, Birgit; Cynis, Holger; Kehlen, Astrid; Arendt, Thomas; Hartlage-Rübsamen, Maike; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2014Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC
Höfling, Corinna; Indrischek, Henrike; Höpcke, Theodor; Waniek, Alexander; Cynis, Holger; Koch, Birgit; Schilling, Stephan; Morawski, Markus; Demuth, Hans-Ulrich; Roßner, Steffen; Hartlage-Rübsamen, Maike
Journal Article
2014Pyroglutamate-Amyloid-β and Glutaminyl Cyclase are Colocalized with Amyloid-β in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion
Cynis, Holger; Funkelstein, Lydiane; Toneff, T.; Mosier, C.; Ziegler, M.; Koch, Birgit; Demuth, Hans-Ulrich; Hook, V.
Journal Article
2013Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration
Becker, Andreas; Kohlmann, Stephanie; Alexandru, Anca; Jagla, Wolfgang; Canneva, Fabio; Bäuscher, Christoph; Cynis, Holger; Sedlmeier, Reinhard; Graubner, Sigrid; Schilling, Stephan; Demuth, Hans-Ulrich; Hörsten, Stephan von
Journal Article
2013Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice
Cynis, Holger; Kehlen, Astrid; Haegele, Monique; Hoffmann, Torsten; Heiser, Ulrich; Fujii, Masato; Shibazaki, Yuichiro; Yoneyama, Hiroyuki; Schilling, Stephan; Demuth, Hans-Ulrich
Journal Article
2013A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues
Güttler, Bert H.-O.; Cynis, Holger; Seifert, Franziska; Ludwig, Hans-Henning; Porzel, Andrea; Schilling, Stephan
Journal Article