Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Konzok, Sebastian; Obernolte, Helena; Dehmel, Susann; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Zardo, Patrick; Warnecke, Gregor; Martin, Christian; Braun, Armin; Sewald, Katherina
Journal Article
2018Characterization of human precision cut liver slices by various viability andfunctional parameters during 24 hour culture
Elenschneider, Leroy; Knebel, Jan; Braun, Armin; Fangmann, J.; Hansen, Tanja
Abstract
2018A computational framework for complex disease stratification from multiple large-scale datasets
Meulder, Bertrand de; Lefaudeux, Diane; Bansal, Aruna T.; Mazein, Alexander; Chaiboonchoe, Amphun; Ahmed, Hassan; Balaur, Irina; Saqi, Mansoor; Pellet, Johann; Ballereau, Stephane; Lemonnier, Nathanaël; Sun, Kai; Pandis, Ioannis; Yang, Xian; Batuwitage, Manohara; Kretsos, Kosmas; Eyll, Jonathan van; Bedding, Alun; Davison, Timothy; Dodson, Paul; Larminie, Christopher; Postle, Anthony; Corfield, Julie; Djukanović, Ratko; Chung, Kian Fan; Adcock, Ian M.; Guo, Yi-Ke; Sterk, Peter J.; Manta, Alexander; Rowe, Anthony; Baribaud, Frédéric; Auffray, Charles; Badorrek, Philipp; Faulenbach, Cornelia; Braun, Armin; Hohlfeld, Jens; Krug, Norbert
Journal Article
2018Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin
Müller, Laura; Murgia, Xabier; Siebenburger, Lorenz; Börger, Carsten; Schwarzkopf, Konrad; Sewald, Katherina; Häussler, Susanne; Braun, Armin; Lehr, Claus-Michael; Hittinger, Marius; Wronski, Sabine
Journal Article
2018Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs
Danov, Olga; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Seehase, Sophie; Dehmel, Susann; Braubach, Peter; Fieguth, Hans-Gerd; Matschiner, Gabriele; Fitzgerald, Mary; Jonigk, Danny; Knauf, Sascha; Pfennig, Olaf; Warnecke, Gregor; Wichmann, Judy; Braun, Armin; Sewald, Katherina
Journal Article
2018Human teratoma-derived hematopoiesis is a highly polyclonal process supported by human umbilical vein endothelial cells
Philipp, Friederike; Selich, Anton; Rothe, Michael; Hoffmann, Dirk; Rittinghausen, Susanne; Morgan, Michael A.; Klatt, Denise; Glage, Silke; Lienenklaus, Stefan; Neuhaus, Vanessa; Sewald, Katherina; Braun, Armin; Schambach, Axel
Journal Article
2018An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages
Beneke, Valerie; Küster, Fennja; Neehus, Anna-Lena; Hesse, Christina; Lopez-Rodriguez, Elena; Haake, Kathrin; Rafiei Hashtchin, Anna; Schott, Juliane Wilhelmine; Walter, Dorothee; Braun, Armin; Wolkers, Willem F.; Ackermann, Mania; Lachmann, Nico
Journal Article
2018Importance of the IL-1 axis in haemophilus influenzae-stimulated M1 macrophages driving transepithelial signaling
Mang, Samuel; Braun, Armin; Pairet, Nicolas; Lamb, David J.
Journal Article
2018Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients
Tschernig, Thomas; Pabst, Reinhard; Prenzler, Frauke; Rittinghausen, Susanne; Braun, Armin; Hohlfeld, Jens M.
Journal Article
2018TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1
Zmora, Pawel; Hoffmann, Markus; Kollmus, Heike; Moldenhauer, Anna-Sophie; Danov, Olga; Braun, Armin; Winkler, Michael; Schughart, Klaus; Pöhlmann, Stefan
Journal Article
2017Evaluation of a human in vitro hepatocyte-NPC co-culture model for the prediction of idiosyncratic drug-induced liver injury: A pilot study
Granitzny, Anne; Knebel, Jan; Müller, Meike; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Journal Article
2017Human effector memory T helper cells engage with mouse macrophages and cause Graft-versus-Host-like pathology in skin of humanized mice used in a nonclinical immunization study
Sundarasetty, Balasai; Volk, Valery; Theobald, Sebastian J.; Rittinghausen, Susanne; Schaudien, Dirk; Neuhaus, Vanessa; Figueiredo, Constanca; Schneider, Andreas; Gerasch, Laura; Mucci, Adele; Moritz, Thomas; Kaisenberg, Constantin von; Spineli, Loukia M.; Sewald, Katherina; Braun, Armin; Weigt, Henning; Ganser, Arnold; Stripecke, Renata
Journal Article
2017Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy
Veres, Tibor Z.; Kopcsányi, Támas; Tirri, Marko; Braun, Armin; Miyasaka, Masayuki; Germain, Ronald N.; Jalkanen, Sirpa; Salmi, Marko
Journal Article
2017Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound
Granitzny, Anne; Knebel, Jan; Schaudien, Dirk; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Journal Article
2017Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin
Zmora, Pawel; Molau-Blazejewska, Paulina; Bertram, Stephanie; Walendy-Gnirß, Kerstin; Nehlmeier, Inga; Hartleib, Anika; Moldenhauer, Anna-Sophie; Konzok, Sebastian; Dehmel, Susann; Sewald, Katherina; Brinkmann, Constantin; Curths, Christoph; Knauf, Sascha; Gruber, Jens; Mätz-Rensing, Kerstin; Dahlmann, Franziska; Braun, Armin; Pöhlmann, Stefan
Journal Article
2017Pseudomonas aeruginosa induziert eine angeborene Immunantwort in frischem Lungengewebe ex vivo
Kraemer, Nadine
: Braun, Armin (1. Prüfer); Häußler, Susanne (2. Prüfer); Wronski, Sabine (Betr.); Müller, Laura (Betr.)
Master Thesis
2016BI 1002494, a novel potent and selective oral spleen tyrosine kinase inhibitor, displays differential potency in human basophils and B cells
Lamb, David J.; Wollin, Stefan Lutz; Schnapp, Andreas; Bischoff, Daniel; Erb, Klaus J.; Bouyssou, Thierry; Guilliard, Bernd; Strasser, Christine; Wex, Eva; Blum, Sylvia; Thaler, Eva; Nickel, Helga; Radmacher, Oliver; Haas, Hannah; Swantek, Jennifer L.; Souza, Don; Canfield, Melissa; White, Della; Panzenbeck, Mark; Kashem, Mohammed A.; Sanville-Ross, Mary; Kono, Takeshi; Sewald, Katherina; Braun, Armin; Obernolte, Helena; Danov, Olga; Schaenzle, Gerhard; Rast, Georg; Maier, Gerd-Michael; Hoffmann, Matthias
Journal Article
2016Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture
Tran, Doan Duy Hai; Koch, Alexandra; Saran, Shashank; Armbrecht, Marcel; Ewald, Florian; Koch, Martina; Wahlicht, Tom; Wirth, Dagmar; Braun, Armin; Nashan, Bjorn; Gaestel, Matthias; Tamura, Teruko
Journal Article
2016Morphology and staining behavior of neutrophilic and eosinophilic granulocytes of the common marmoset (Callithrix jacchus)
Bleyer, Martina; Curths, Christoph; Dahlmann, Franziska; Wichmann, Judy; Bauer, Natali; Moritz, Andreas; Braun, Armin; Knauf, Sascha; Kaup, Franz-Josef; Gruber-Dujardin, Eva
Journal Article
2016Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity
Hess, A.; Wang-Lauenstein, Lan; Braun, Armin; Kolle, S.N.; Landsiedel, Robert; Liebsch, M.; Ma-Hock, Lan; Pirow, R.; Schneider, X.; Steinfath, M.; Vogel, S.; Martin, C.; Sewald, Katherina
Journal Article
2016Steroid treatment reduces allergic airway inflammation and does not alter the increased numbers of dendritic cells and calcitonin gene-related peptide-expressing neurons in airway sensory ganglia
Le, Duc Dung; Funck, Ulrike; Wronski, Sabine; Heck, Sebastian; Tschernig, Thomas; Bischoff, Markus; Sester, Martina; Herr, Christian; Bals, Robert; Welte, Tobias; Braun, Armin; Dinh, Quoc Thai
Journal Article
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices
Obernolte, Helena; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Comparison of fibrotic and emphysematous alterations in the lungs of bleomycin-treated rats and hamsters
Hoymann, Heinz-G.; Schaudien, Dirk; Hansen, Tanja; Müller, Meike; Braun, Armin
Abstract
2015Development of a human organotypic tumor invasion model of cancer cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS)
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Eosinophils of the marmoset monkey (callithrix jacchus)
Gruber-Dujardin, E.; Curths, Christoph; Bleyer, Martina; Taubert, S.; Bauer, N.; Moritz, A.; Dahlmann, Franziska; Braun, Armin; Knauf, Sascha; Kaup, Franz Josef
Abstract
2015House-dust-mite induced features of asthma in marmoset monkeys
Curths, Christoph; Dahlmann, Franziska; Wichmann, Judy; Becker, Tamara; Knauf, Y.; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Abstract
2015Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Niedrig dosierte inhalative Endotoxin Provokation bei gesunden Probanden als Modell in der klinischen Atemwegsforschung
Janssen, Ole
: Hohlfeld, Jens M. (Betreuer); Braun, Armin (Referent); Dittrich, Anna-Maria (Korreferent)
Dissertation
2015A novel human organotypic tumor invasion model of cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS) to reduce animal experiments in preclinical oncology
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Peripheral sensory nerves stimulation lead to bronchoconstriction-augment in passive sensitized human precision-cut lung slices and Is histamine 1 receptor dependent
Jiménez Delgado, Sharon Melissa; Schindler, Susann; Sewald, Katherina; Braun, Armin
Abstract
2015Precision-cut lung slices as an alternative model for repeated-dose inhalation toxicity
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Syliva; Braun, Armin; Sewald, Katherina
Abstract
2015Risk assessment of inhalable read-across chemicals with different mode of action showed great differences in cytotoxicity in rat and human precision-cut lung slices
Danov, Olga; Schröder, Katrin; Braubach, Peter; Jonigk, D.; Warnecke, G.; Braun, Armin; Escher, Syliva; Sewald, Katherina
Abstract
2015The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells
Holst, Katrin; Guseva, Daria; Schindler, Susann; Sixt, Michael; Braun, Armin; Chopra, Himpriya; Pabst, Oliver; Ponimaskin, Evgeni
Journal Article
2015Species comparison of rat and human precision-cut lung slices as an alternative in risk assessment based on read-across approach
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Bersch, Claus; Braubach, Peter; Jonigk, Danny; Pfennig, Olaf; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015TRPA1 agonists modulate the trachealis muscle tone via two independent mechanisms
Haider, Georg; Lee, Jae Hwa; Wiegand, Silke; Spies, Emma; Hoymann, Heinz-Gerd; Kummer, Wolfgang; Braun, Armin; Nassenstein, Christina
Abstract
2014Airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets (Callithrix jacchus)
Curths, Christoph; Wichmann, Judy; Dunker, Sarah; Windt, Horst; Hoymann, Heinz-Gerd; Lauenstein, Hans D.; Hohlfeld, Jens M.; Becker, Tamara; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Journal Article
2014Allergische Atemwegsentzündung induziert eine Zunahme von Dendritischen Zellen in den Atemwegsganglien der Maus
Le, Duc Dung; Rochlitzer, Sabine; Heck, Sebastian; Bals, Robert; Braun, Armin; Welte, Tobias; Dinh, Quoc Thai
Abstract
2014Alternative model for repeated dose inhalation toxicity using precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Sylvia; Schaudien, Dirk; Braun, Armin; Sewald, Katherina
Abstract
2014Biological impact of modified inhalable carbon black nanoparticles assessed in cell and tissue culture models
Danov, Olga; Kopf, Johannes; Ströbele, M.; Bockhorn, H.; Fehrenbach, H.; Braun, Armin; Sewald, Katherina; Hansen, Tanja
Abstract
2014Biomarker for eosinophil and T-cell recruitment induced by interleukin-13 as a therapeutic target for allergic asthma tested in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, H.; Pfennig, Olaf; Förster, C.; Hohlbaum, A.; Audoly, L.; Braun, Armin; Sewald, Katherina
Abstract
2014Biotechnologie statt Tierversuche
Braun, Armin
Journal Article
2014Characterization of ex vivo immunostimulated dendritic cells in murine lung tissue
Brandstetter, Ronja Lorena
: Braun, Armin (Gutachter); Schwinzer, Reinhard (Gutachter)
Master Thesis
2014Characterization of IL-13- and allergen-induced airway hyperreactivity in precision-cut lung slices of different species
Drake, Helena
: Förster, Irmgard (Supervisor); Burgdorf, Sven (Supervisor); Sewald, Katherina (Advisor); Braun, Armin (Advisor)
Master Thesis
2014Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study
Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Othmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert
Journal Article
2014Ex vivo models for asthma, COPD and lung injury in precision cut lung slices (PCLS)
Sewald, Katherina; Braun, Armin
Abstract
2014Frühe Phase der Allergen-induzierten Atemwegsreaktion beim Weißbüschelaffen nach passiver Sensibilisierung von Lungengewebe mit humanem Blutplasma
Wichmann, Judy; Jiménez Delgado, Sharon Melissa; Curths, Christoph; Becker, Tamara; Kaup, Franz Josef; Braun, Armin; Sewald, Katherina; Knauf, Sascha
Abstract
2014A human in vitro allergy model showing allergen specific immune responses using house dust mite or grass pollen allergen
Müller, Meike; Schaumann, Frank; Braun, Armin
Abstract
2014Human organotypic cancer model
Konzok, Sebastian; Schindler, Susann; Braun, Armin; Sewald, Katherina
Abstract
2014IL-13 induced asthma model in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, H.; Seehase, Sophie; Hohlbaum, A.M.; Bersch, C.; Jonigk, D.; Warnecke, G.; Braun, Armin; Sewald, Katherina
Abstract
2014Interleukin-13 as a therapeutic target for allergic asthma tested in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Pfennig, Olaf; Forster, Christine; Hohlbaum, Andreas; Audoly, Laurent; Braun, Armin; Sewald, Katherina
Abstract
2014Invasion, proliferation and influence of cancer cell line MDA-MB-231 on organotypic tissue using Precision Cut Lung Slices (PCLS)
Konzok, Sebastian
: Braun, Armin (Supervisor); Tamura-Niemann, Teruko (Supervisor)
Master Thesis
2014Invasive but repetitive lung function measurements in a rodent model of pulmonary fibrosis
Hoymann, Heinz-Gerd; Ernst, Heinrich; Creutzenberg, Otto H.; Schaudien, Dirk; Müller, Meike; Knudsen, Lars; Braun, Armin
Abstract
2014Kinetikanalysen des Aktivierungszustandes von ex vivo stimulierten dendritischen Zellen im murinen PCLS Modell
Baron, Lena
: Braun, Armin (1. Gutachter); Schwinzer, Reinhard (2. Gutachter)
Master Thesis
2014Lung function assessment in nonhuman primate models of obstructive pulmonary diseases
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz-Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Lung function assessment in the common marmoset (Callithrix jacchus) for the evaluation of translational nonhuman primate models of lung inflammation
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Lung tissue culture model for assessment of cytotoxicity and inflammation induced by inhalable carbon black nanoparticles
Braun, Armin; Danov, Olga; Kopf, Johannes Claudius; Ströbele, Michael; Hansen, Tanja; Fehrenbach, Heinz; Sewald, Katherina
Abstract
2014A model of neuronal hyperreactivity in passive sensitized human organotypic tissue
Schindler, Susann; Jiménez Delgado, Sharon Melissa; Braun, Armin
Abstract
2014Murine precision-cut liver slices (PCLS): A new tool for studying tumor microenvironments and cell signaling ex vivo
Koch, Alexandra; Saran, Shashank; Tran, Doan Duy Hai; Klebba-Färber, Sabine; Thiesler, Hauke; Sewald, Katherina; Schindler, Susann; Braun, Armin; Klopfleisch, Robert; Tamura, Teruko
Journal Article
2014Neuronale Plastizität in NGF-transgenen Mäusen bei allergischen Atemwegentzündungen
Dinh, Quoc Thai; Quarcoo, David; Braun, Armin; Welte, Tobias; Bals, Robert; Fischer, A.
Abstract
2014A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung
Neuhaus, Vanessa; Chichester, Jessica A.; Ebensen, Thomas; Schwarz, Katharina; Cartman, Caitlin E.; Shoji, Yoko; Guzman, Carlos A.; Yusibov, Vidadi; Sewald, Katherina; Braun, Armin
Journal Article
2014New treatment strategies for respiratory diseases: Ex vivo and in vivo evaluation of pharmacological immunomodulations using a nanoparticle-based drug delivery system
Neuhaus, Vanessa
: Braun, Armin (Supervisor); Dittrich, Anna-Maria (Cosupervisor); Müller-Goymann, Christel (Cosupervisor)
Dissertation
2014No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model
Rochlitzer, Sabine; Hoymann, Heinz-Gerd; Müller, Meike; Braun, Armin
Journal Article
2014Passively sensitized precision-cut lung slices from marmoset monkeys as a preclinical assay to test novel IgE inhibitors
Wichmann, Judy; Jiménez Delgado, Sharon Melissa; Curths, Christoph; Becker, Tamara; Eggel, Alexander; Kaup, Franz-Josef; Braun, Armin; Sewald, Katherina; Knauf, Sascha
Abstract
2014Pre-validation of the ex vivo model precision-cut lung slices (PCLS) for prediction of acute inhalation toxicity
Sewald, Katherina; Lauenstein, Lan; Schneider, X.; Pirow, R.; Steinfath, M.; Ma-Hock, L.; Liebsch, M.; Landsiedel, R.; Braun, Armin; Martin, C.
Abstract
2014Precision-cut lung slices as alternative to mimic inflammation, lung injury and bronchoconstriction after short and long-term maintenance in culture
Neuhaus, Vanessa; Schaudien, Dirk; Sewald, Katherina; Braun, Armin
Abstract
2014Prevalidation of the ex vivo model PCLS for the prediction of acute inhalation toxicity
Sewald, Katherina; Hess, A.; Lauenstein, Lan; Schneider, X.; Vogel, S.; Steinfath, M.; Pirow, R.; Liebsch, M.; Kolle, S.; Ma-Hock, L.; Landsiedel, R.; Martin, C.; Braun, Armin
Abstract
2014Rhinovirus infection in human and mouse precision cut lung slices
Rochlitzer, Sabine; Müller, Meike; Sewald, Katherina; Braun, Armin
Abstract
2014Species comparison of interleukin-13 induced airway hyperreactivity in precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, Helena; Schindler, Susann; Pfennig, Olaf; Förster, Christine; Braun, Armin; Sewald, Katherina
Journal Article, Conference Paper
2014Toxicity testing of sildenafil base-loaded liposomes in in vitro and ex vivo models for pulmonary application
Paranjpe, Mukta; Neuhaus, Vanessa; Braun, Armin; Müller-Goymann, Christel C.
Journal Article
2014Use of rat precision-cut lung slices for long-term functional evaluation
Neuhaus, Vanessa; Braun, Armin; Sewald, Katherina
Abstract
2014Veränderung von MHC-II positiven Zellen der Atemwegsganglien bei chronischem Hausstaubmilben-Mausmodell und HRV1B Infektion
Funck, Ulrike; Le, Duc Dung; Rochlitzer, Sabine; Heck, Sebastian; Bals, Robert; Braun, Armin; Welte, Tobias; Dinh, Quoc Thai
Abstract
2013Aeroallergen challenge promotes dendritic cell proliferation in the airways
Veres, Tibor Z.; Voedisch, Sabrina; Spies, Emma; Valtonen, Joona; Prenzler, Frauke; Braun, Armin
Journal Article
2013Anti-inflammatory and immunomodulatory properties of alpha1-antitrypsin without inhibition of elastase
Jonigk, Danny; Al-Omari, Mariam; Maegel, Lavinia; Müller, Meike; Izykowski, Nicole; Hong, Jaewoo; Hong, Kwangwon; Kim, Soo-Hyun; Dorsch, Martina; Mahadeva, Riva; Laenger, Florian; Kreipe, Hans; Braun, Armin; Shahaf, Galit; Lewis, Eli C.; Welte, Tobias; Dinarello, Charles A.; Janciauskiene, Sabina
Journal Article
2013Assessment of immunotoxicity using precision-cut tissue slices
Sewald, Katherina; Braun, Armin
Journal Article
2013Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice
Hox, Valérie; Vanoirbeek, Jeron A.; Alpizar, Yeranddy Aguiar; Voedisch, Sabrina; Callebaut, Ina; Bobic, Sonja; Sharify, Ali; Vooght, Vanessa de; Gerven, Laura van; Devos, Fien; Liston, Adrian; Voets, Thomas; Vennekens, Rudi; Bullens, Dominique M.A.; Vries, Annick de; Hoet, Peter; Braun, Armin; Ceuppens, Jan L.; Talavera, Karel; Nemery, Benoit; Hellings, Peter W.
Journal Article
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Journal Article
2013Effects of carbon black nanoparticles on human pulmonary cell lines and precision cut lung slices
Hansen, Tanja; Kopf, Johannes Claudius; Danov, Olga; Ströbele, M.; Braun, Armin; Sewald, Katherina; Steinberg, P.; Fehrenbach, H.
Journal Article, Conference Paper
2013Effects of dipeptidyl peptidase-4 inhibition in an animal model of experimental asthma: A matter of dose, route, and time
Stephan, Michael; Suhling, Hendrik; Schade, Jutta; Wittlake, Mareike; Tasic, Tihana; Klemann, Christian; Pabst, Reinhard; Jurawitz, Marie-Charlot; Raber, Kerstin A.; Hoymann, Heinz G.; Braun, Armin; Glaab, Thomas; Hoffmann, Torsten; Schmiedl, Andreas; Hoersten, S. von
Journal Article
2013Expression of VPAC1 in a murine model of allergic asthma
Lauenstein, Hans D.; Quarcoo, David; Welte, Tobias; Braun, Armin; Groneberg, David A.
Journal Article
2013Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique
Neuhaus, Vanessa; Schwarz, Katharina; Klee, Anna; Seehase, Sophie; Förster, Christine; Pfennig, Olaf; Jonigk, Danny; Fieguth, Hans-Gerd; Koch, Wolfgang; Warnecke, Gregor; Yusibov, Vidadi; Sewald, Katherina; Braun, Armin
Journal Article
2013IL-13-induced cytokine release and hyperresponsiveness in precision cut lung slices of different species - characterization of a model potentially suitable for translational research of asthma cellular events
Jiménez Delgado, Sharon Melissa; Danov, Olga; Braun, Armin; Pfenning, Olaf; Förster, Christine; Hohlbaum, Andreas; Audoly, Laurent; Hohlfeld, Jens; Sewald, Katherina
Journal Article, Conference Paper
2013IL-13-induced inflammation and hyperreagibility in precision-cut lung slices of different species
Jiménez Delgado, Sharon Melissa
: Braun, Armin (Supervisor); Schuberth, Hans-Joachim (Supervisor)
Master Thesis
2013In vitro and ex vivo toxicity screening for predicting toxicological effects of synthetic carbon black nanoparticles in humans
Hansen, Tanja; Kopf, Johannes; Danov, Olga; Ströbele, Michael; Braun, Armin; Sewald, Katherina; Bockhorn, H.; Fehrenbach, Heinz
Journal Article, Conference Paper
2013Invasive lung function measurement in common marmosets (Callithrix jacchus)
Wichmann, Judi; Curths, Christoph; Dunker, Sarah; Windt, Horst; Hoymann, Heinz Gerd; Lauenstein, Hans Dieter; Becker, Tamara; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Pre-validation of the ex vivo model precision cut lung slices (PCLuS) for the prediction of respiratory toxicology
Hess, A.; Lauenstein, Lan; Schneider, X.; Vogel, S.; Ma-Hock, L.; Kolle, S.; Martin, C.; Pirow, R.; Steinfath, M.; Liebsch, M.; Landsiedel, R.; Braun, Armin; Sewald, Katherina
Journal Article, Conference Paper
2013Prevalidation of the ex vivo model precision cut lung slices (PCLS) for the prediction of respiratory toxicology
Sewald, Katherina; Lauenstein, Lan; Vogel, S.; Hess, A.; Schneider, X.; Martin, C.; Pirow, R.; Liebsch, M.; Landsiedel, R.; Braun, Armin
Journal Article, Conference Paper
2013Severity of allergic airway disease due to house dust mite allergen is not increased after clinical recovery of lung infection with chlamydia pneumoniae in mice
Dutow, Pavel; Lingner, Sandra; Laudeley, Robert; Glage, Silke; Hoymann, Heinz-Gerd; Dittrich, Anna-Maria; Fehlhaber, Beate; Müller, Meike; Braun, Armin; Klos, Andreas
Journal Article
2013A translational non-human primate model for human asthma in the common marmoset (Callithrix Jacchus)
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens M.; Sewald, Katherina; Windt, Horst; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales LPS-Modell zur präklinischen Testung anti-inflammatorischer Substanzen im Weißbüschelaffen (Callithrix jacchus)
Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz Josef; Schlumbohm, Christina; Fuchs, E.; Lauenstein, Hans Dieter; Sewald, Katherina; Hohlfeld, Jens M.; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales Tiermodel für das allergische Asthma des Menschen im Weißbüschelaffen (Callithrix jacchus)
Curths, Christoph; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales Tiermodell für das allergische Asthma des Menschen im Weißbüschelaffen (Callithrix jacchus)
Curths, Christoph; Becker, T.; Kaup, Franz Josef; Schlumbohm, Christina; Sewald, Katherina; Hohlfeld, Jens M.; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2012Acute cigarette smoke exposure induces cytotoxicity and inflammation in living tissue of precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Ritter, Detlef; Knebel, Jan; Dasenbrock, Clemens; Braun, Armin; Sewald, Katherina
Abstract
2012Assessment of lung toxicity induced by chemical allergens in human precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Prenzler, Frauke; Pfennig, Olaf; Förster, Christine; Braun, Armin; Sewald, Katherina
Abstract
2012Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function
Langer, Marybeth; Duggan, Elizabeth S.; Booth, John L.; Patel, Vineet I.; Zander, Ryan A.; Silasi-Mansat, Robert; Ramani, Vijay; Veres, Tibor Z.; Prenzler, Frauke; Sewald, Katherina; Williams, Daniel M.; Coggeshall, Kenneth M.; Awasthi, Shanjana; Lupu, Florea; Burian, Dennis; Ballard, Jimmy D.; Braun, Armin; Metcalf, Jordan P.
Journal Article
2012Bacterial infection triggers exacerbation of established pulmonary fibrosis in mice: Impact on lung protective immunity
Ueberberg, Bianca; Janze, Ann-Kathrin; Steinwede, Kathrin; Maus, Regina; Magel, Lavinia; Hoymann, Heinz-Gerd; Braun, Armin; Langer, Florian; Jonigk, Danny; Kolb, Martin; Gauldie, Jack; Welte, Tobias; Maus, Ulrich A.
Abstract
2012Cathepsin G and neutrophil elastase contribute to lung protective immunity against mycobacterial infections in mice
Steinwede, Kathrin; Maus, Regina; Bohling, Jennifer; Voedisch, Sabrina; Braun, Armin; Ochs, Matthias; Schmiedl, Andreas; Walter, Kerstin; Bange, Franz; Welte, Tobias; Ehlers, Stefan; Maus, Ulrich A.
Abstract
2012Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice
Steinwede, Kathrin; Maus, Regina; Bohling, Jennifer; Voedisch, Sabrina; Braun, Armin; Ochs, Matthias; Schmiedl, Andreas; Länger, Florian; Gauthier, Francis; Roes, Jürgen; Welte, Tobias; Bange, Franz C.; Niederweis, Michael; Bühling, Frank; Maus, Ulrich A.
Journal Article
2012Effect of Tiotropium on in vivo and ex vivo lung function in a rat model of bronchoconstriction
Seehase, Sophie; Köhncke, Sarah-Philine; Hoymann, Heinz-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2012Ex vivo lung culture models of marmoset monkeys and humans for anti-inflammatory drug testing
Seehase, Sophie; Neuhaus, Vanessa; Kaup, Franz-Josef; Pfennig, O.; Förster, Christine; Hohlfeld, Jens Michael; Knauf, Sascha; Braun, Armin; Sewald, Katherina
Abstract
2012Human alveolar epithelial barrier function is impaired by bacillus anthracis lethal toxin
Langer, Marybeth; Booth, John L.; Patel, Vineet I.; Duggan, Elizabeth S.; Braun, Armin; Ramani, Vijay; Awasthi, Shanjana; Silasi-Mansat, Robert; Lupu, Florea; Coggeshall, Kenneth M.; Metcalf, Jordan P.
Abstract
2012Immunotoxic characterization of a nanoparticle-based inhalable influenza vaccine in murine and human precision cut lung slices
Neuhaus, Vanessa; Schwarz, Katharina; Koch, Wolfgang; Sewald, Katherina; Yusibov, V.; Braun, Armin
Abstract
2012Marmoset monkeys as a preclinical model in respiratory research
Seehase, Sophie
: Kaup, Franz-Josef (1. Gutachter); Zimmermann, Elke (2. Gutachterin); Braun, Armin (Wiss. Betreuung)
Dissertation
2012Neuro-immune interaction in allergic airway inflammation: Expression and function of dendritic cells in sensory airway ganglia neurons
Le, Dung D.; Rochlitzer, Sabine; Funck, Ulrke; Suhling, Hendrik; Braun, Armin; Welte, Tobias; Din, Quoc Thai
Abstract
2012Neuropeptides influence airway dendritic cell behavior
Braun, Armin; Spies, Emma; Rochlitzer, Sabine; Voedisch, Sabrina
Abstract
2012A new model for testing human specific anti-inflammatory drugs: LPS-induced lung inflammation in the common marmoset
Knauf, Sascha; Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz-Josef; Schlumbohm, Christina; Fuchs, Eberhard; Lauenstein, Hand D.; Sewald, Katherina; Hohlfeld, Jens Michael; Braun, Armin
Abstract
2012The respiratory tract
Braun, Armin; Ernst, Heinrich; Schaudien, Dirk; Hoymann, Heinz-Gerd; Rittinghausen, Susanne
Book Article
2012Rhinovirus application on the background of allergic airway inflammation in a chronic house dust mite model
Rochlitzer, Sabine; Hoymann, Heinz-Gerd; Müller, Meike; Braun, Armin
Abstract
2012Surfactant protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
Schleh, Carsten; Rothen-Rutishauser, Barbara M.; Blank, Fabian; Lauenstein, Hans D.; Nassimi, Matthias; Krug, Norbert; Braun, Armin; Erpenbeck, Veit; Gehr, Peter; Hohlfeld, Jens M.
Journal Article
2011Characterization of local respiratory irritation and inflammation after acute exposure to biological and chemical substances in PCLS
Switalla, S.
: Steinhagen, D. (Referent); Braun, Armin (Korreferent); Bicker, Gerd (Korreferent)
Dissertation
2011Mechanisms of bronchoconstriction in precision-cut lung slices of non-human primates are comparable to human
Seehase, Sophie; Schlepütz, M.; Switalla, Simone; Fuchs, E.; Kaup, F.-J.; Ressmeyer, A.R.; Uhlig, S.; Lauenstein, Hans-Dieter; Braun, Armin; Martin, C.; Sewald, Katherina
Conference Paper, Journal Article
2011Neuronale Kontrolle bei chronisch entzündlichen und obstruktiven Lungenerkrankungen wie Asthma bronchiale und COPD
Dinh, Q.T.; Suhling, H.; Fischer, A.; Braun, Armin; Welte, Tobias
Journal Article
2011The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function
Rochlitzer, Sabine; Veres, Tibor Z.; Kühne, Kathleen; Prenzler, Frauke; Pilzner, Carolin; Knothe, Saskia; Winkler, Carla; Lauenstein, Hans-Dieter; Willart, M.; Hammad, H.; Müller, Meike; Krug, Norbert; Lambrecht, Bart N.; Braun, Armin
Journal Article
2011PCLS: From learning about 'in vivo' to reduction and replacement
Sewald, Katherina; Braun, Armin
Book Article
2011The phosphodiesterase-4-inhibitor Roflumilast reduces LPS-induced lung inflammation in common marmoset monkeys
Seehase, Sophie; Switalla, Simone; Prenzler, Frauke; Fuchs, E.; Schlumbohm, C.; Kaup, F.-J.; Sewald, Katherina; Lauenstein, Hans-Dieter; Braun, Armin
Conference Paper, Journal Article
2011Spatiotemporal and functional behavior of airway dendritic cells visualized by two-photon microscopy
Veres, Tibor Z.; Voedisch, Sabrina; Spies, Emma; Tschernig, Thomas; Braun, Armin
Journal Article