Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins
Fuhrmann, D.C.; Olesch, C.; Kurrle, N.; Schnütgen, F.; Zukunft, S.; Fleming, I.; Brüne, B.
Journal Article
2019Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells
Trümper, V.; Knethen, A. von; Preuß, A.; Ermilov, E.; Hackbarth, S.; Kuchler, L.; Gunne, S.; Schäfer, A.; Bornhütter, T.; Vereb, G.; Ujlaky-Nagy, L.; Brüne, B.; Röder, B.; Schindler, M.; Parnham, M.J.; Knape, T.
Journal Article
2019GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells
Wegner, M.-S.; Gruber, L.; Schömel, N.; Trautmann, S.; Brachtendorf, S.; Fuhrmann, D.; Schreiber, Y.; Olesch, C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2019Histone Deacetylation Inhibitors as Therapy Concept in Sepsis. Review
Knethen, A. von; Brüne, B.
Journal Article
2019IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells
Han, Y.; Mora, J.; Huard, A.; Silva, P. da; Wiechmann, S.; Putyrski, M.; Schuster, C.; Elwakeel, E.; Lang, G.; Scholz, A.; Scholz, T.; Schmid, T.; Bruin, N. de; Billuart, P.; Sala, C.; Burkhardt, H.; Parnham, M.J.; Ernst, A.; Brüne, B.; Weigert, A.
Journal Article
2019Iron as a Central Player and Promising Target in Cancer Progression. Review
Jung, M.; Mertens, C.; Tomat, E.; Brüne, B.
Journal Article
2019Macrophage HIF‐2α regulates tumor-suppressive Spint1 in the tumor microenvironment
Susen, R.M.; Bauer, R.; Olesch, C.; Fuhrmann, D.C.; Fink, A.F.; Dehne, N.; Jain, A.; Ebersberger, I.; Schmid, T.; Brüne, B.
Journal Article
2019Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation
Weigert, A.; Knethen, A. von; Thomas, D.; Faria, I.; Namgaladze, D.; Zezina, E.; Fuhrmann, D.; Petcherski, A.; Meyer zu Heringdorf, D.; Radeke, H.H.; Brüne, B.
Journal Article
2019Sphingosine-1-Phosphate and Macrophage Biology - How the Sphinx Tames the Big Eater
Weigert, A.; Olesch, C.; Brüne, B.
Journal Article
2019Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis
Knethen, A. von; Schäfer, A.; Kuchler, L.; Knape, T.; Christen, U.; Hintermann, E.; Fißlthaler, B.; Schröder, K.; Brandes, R.P.; Genz, B.; Abshagen, K.; Pützer, B.M.; Sha, L.K.; Weigert, A.; Syed, S.N.; Schulz, M.; Shah, A.M.; Ernst, A.; Putyrski, M.; Finkelmeier, F.; Pesic, M.; Greten, F.; Hogardt, M.; Kempf, V.A.J.; Gunne, S.; Parnham, M.J.; Brüne, B.
Journal Article
20188-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model
Shirsath, N.; Wagner, K.; Tangermann, S.; Schlederer, M.; Ringel, C.; Kenner, L.; Brüne, B.; Wolf, P.
Journal Article
2018AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages
Kirchner, J.; Brüne, B.; Namgaladze, D.
Journal Article
2018Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
Ringleb, J.; Strack, E.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Weigert, A.; Brüne, B.
Journal Article
2018C5aR activation in the absence of C5a
Syed, S.N.; Rau, E.; Ziegelmann, M.; Sogkas, G.; Brüne, B.; Schmidt, R.E.
Journal Article
2018Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
Brachtendorf, S.; Wanger, R.A.; Birod, K.; Thomas, D.; Trautmann, S.; Wegner, M.-S.; Fuhrmann, D.C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2018Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma
Sekar, D.; Govene, L.; Del Río, M.-L.; Sirait-Fischer, E.; Fink, A.F.; Brüne, B.; Rodriguez-Barbosa, J.I.; Weigert, A.
Journal Article
2018Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses
Zezina, E.; Snodgrass, R.G.; Schreiber, Y.; Zukunft, S.; Schürmann, C.; Meyer zu Heringdorff, D.; Geisslinger, G.; Fleming, I.; Brandes, R.P.; Brüne, B.; Namgaladze, D.
Journal Article
2018The portal vein as a distinct immunological compartment
Queck, A.; Rueschenbaum, S.; Kubesch, A.; Cai, C.; Zeuzem, S.; Weigert, A.; Brüne, B.; Nour-Eldin, A.; Gruber-Rouh, T.; Vogl, T.; Lange, C.M.
Journal Article
2018The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage
Treutlein, E.-M.; Kern, K.; Weigert, A.; Tarighi, N.; Schuh, C.-D.; Nüsing, R.M.; Schreiber, Y.; Ferreirós, N.; Brüne, B.; Geisslinger, G.; Pierre, S.; Scholich, K.
Journal Article
2018Redox-signals and macrophage biology
Weigert, A.; Knethen, A. von; Fuhrmann, D.; Dehne, N.; Brüne, B.
Journal Article
2017Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis
Netzer, C.; Knape, T.; Kuchler, L.; Weigert, A.; Zacharowski, K.; Pfeilschifter, W.; Sempowski, G.; Parnham, M.J.; Brüne, B.; Knethen, A. von
Journal Article
2017Beyond Immune Cell Migration
Olesch, C.; Ringel, C.; Brüne, B.; Weigert, A.
Journal Article
2017Cancer cell and macrophage cross-talk in the tumor microenvironment
Dehne, N.; Mora, J.; Namgaladze, D.; Weigert, A.; Brüne, B.
Journal Article
2017Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice
Oertel, S.; Scholich, K.; Weigert, A.; Thomas, D.; Schmetzer, J.; Trautmann, S.; Wegner, M.S.; Radeke, H.H.; Filmann, N.; Brüne, B.; Geisslinger, G.; Tegeder, I.; Grösch, S.
Journal Article
2017Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis
Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Knape, T.; Angioni, C.; Ferreiros, N.; Schmidt, M.V.; Weigert, A.; Brüne, B.; Knethen, A. von
Journal Article
2017GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency
Scholz, T.; Weigert, A.; Brüne, B.; Sadik, C.D.; Böhm, B.; Burkhardt, H.
Journal Article
2017Iron handling in tumor-associated macrophages - is there a new role for lipocalin-2?
Jung, M.; Weigert, A.; Mertens, C.; Rehwald, C.; Brüne, B.
Journal Article
2017Lipocalin-2 and iron trafficking in the tumor microenvironment
Jung, M.; Mertens, C.; Bauer, R.; Rehwald, C.; Brüne, B.
Journal Article
2017Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
Mertens, C.; Mora, J.; Ören, B.; Grein, S.; Winslow, S.; Scholich, K.; Weigert, A.; Malmström, P.; Forsare, C.; Fernö, M.; Schmid, T.; Brüne, B.; Jung, M.
Journal Article
2017Mitochondrial composition and function under the control of hypoxia
Fuhrmann, D.C.; Brüne, B.
Journal Article
2017Nrf2, the master regulator of anti-oxidative responses
Vomund, S.; Schäfer, A.; Parnham, M.J.; Brüne, B.; Knethen, A. von
Journal Article
2017PPARgamma as a putative stress marker in T cells following kidney transplantation
Aghajaanpour, R.; Brenneis, M.; Köhler, N.; Knape, T.; Büttner, S.; Kuchler, L.; Parnham, M.J.; Bruene, B.; Hauser, I.A.; Knethen, A. von
Abstract
2017S1P provokes tumor lymphangiogenesis via macrophage-derived mediators such as IL-1β or Lipocalin-2
Syed, S.N.; Jung, M.; Weigert, A.; Brüne, B.
Journal Article
2017S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β
Weichand, B.; Popp, R.; Dziumbla, S.; Mora, J.; Strack, E.; Elwakeel, E.; Frank, A.-C.; Scholich, K.; Pierre, S.; Syed, S.N.; Olesch, C.; Ringleb, J.; Ören, B.; Döring, C.; Savai, R.; Jung, M.; Knethen, A. von; Levkau, B.; Fleming, I.; Weigert, A.; Brüne, B.
Journal Article
2016AMPK-independent inhibition of human macrophage ER stress response by AICAR
Boß, M.; Newbatt, Y.; Gupta, S.; Collins, I.; Brüne, B.; Namgaladze, D.
Journal Article
2016Apoptosis-induced tolerance. Role of the novel cytokine IL-38
Mora, J.; Han, Y.; Wittig, I.; Putyrski, M.; Ernst, A.; Brüne, B.; Weigert, A.
Abstract
2016Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4
Schmid, T.; Blees, J.S.; Bajer, M.M.; Wild, J.; Pescatori, L.; Crucitti, C.; Scipione, L.; Costi, R.; Henrich, C.J.; Brüne, B.; Colburn, N.H.; Santo, R. di
Journal Article
2016Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses
Mora, J.; Schlemmer, A.; Wittig, I.; Richter, F.; Putyrski, M.; Frank, A.-C.; Han, Y.; Jung, M.; Ernst, A.; Weigert, A.; Brüne, B.
Journal Article
2016Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model
Henke, N.; Ferreirós, N.; Geisslinger, G.; Ding, M.G.; Essler, S.; Fuhrmann, D.C.; Geis, T.; Namgaladze, D.; Dehne, N.; Brüne, B.
Journal Article
2016Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation
Namgaladze, D.; Brüne, B.
Journal Article
2016N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators
Blöcher, R.; Lamers, C.; Wittmann, S.K.; Merk, D.; Hartmann, M.; Weizel, L.; Diehl, O.; Brüggerhoff, A.; Boss, M.; Kaiser, A.; Schader, T.; Gobel, T.; Grundmann, M.; Angioni, C.; Heering, J.; Geisslinger, G.; Wurglics, M.; Kostenis, E.; Brüne, B.; Steinhilber, D.; Schubert-Zsilavecz, M.; Kahnt, A.S.; Proschak, E.
Journal Article
2016N-terminally truncated interleukin-38
Weigert, Andreas; Mora, Javier; Brüne, Bernhard; Dillmann, Christina; Parnham, Michael John
Patent
2016Tumour stroma‐derived lipocalin‐2 promotes breast cancer metastasis
Ören, B.; Urosevic, J.; Mertens, C.; Mora, J.; Guiu, M.; Gomis, R.R.; Weigert, A.; Schmid, T.; Grein, S.; Brüne, B.; Jung, M.
Journal Article
2015Activation of the peroxisome proliferator-activated receptor γ counteracts sepsis-induced T cell cytotoxicity toward alloantigenic target cells
Knethen, A. von; Sha, L.K.; Knape, T.; Kuchler, L.; Giegerich, A.K.; Schulz, M.; Hauser, I.A.; Brüne, B.
Journal Article
2015AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages
Namgaladze, D.; Snodgrass, R.G.; Angioni, C.; Grossmann, N.; Dehne, N.; Geisslinger, G.; Brüne, B.
Journal Article
2015Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling
Winkel, A.F.; Engel, C.K.; Margerie, D.; Kannt, A.; Szillat, H.; Glombik, H.; Kallus, C.; Ruf, S.; Güssregen, S.; Riedel, J.; Herling, A.W.; Knethen, A. von; Weigert, A.; Brüne, B.; Schmoll, D.
Journal Article
2015Identification and characterisation of a prototype for a new class of competitive PPAR gamma antagonists
Knape, T.; Flesch, D.; Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Labocha, S.; Ferreirós, N.; Schmid, T.; Wurglics, M.; Schubert-Zsilavecz, M.; Proschak, E.; Brüne, B.; Parnham, M.J.; Knethen, A. von
Journal Article
2015Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability
Sha, L.K.; Sha, W.; Kuchler, L.; Daiber, A.; Giegerich, A.K.; Weigert, A.; Knape, T.; Snodgrass, R.; Schröder, K.; Brandes, R.P.; Brüne, B.; Knethen, A. von
Journal Article
2015MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer
Olesch, C.; Sha, W.; Angioni, C.; Sha, L.K.; Acaf, E.; Patrignani, P.; Jakobsson, P.-J.; Radeke, H.H.; Grösch, S.; Geisslinger, G.; Knethen, A. von; Weigert, A.; Brüne, B.
Journal Article
2015PPAR(3) expression in human T cells may serve as a new prognostic marker for sepsis outcome
Brenneis, M.; Aghajaanpour, R.; Knape, T.; Hauser, I.A.; Büttner, S.; Neb, H.; Meybohm, P.; Zacharowski, K.; Parnham, M.J.; Brüne, B.; Knethen, A.
Abstract
2014Activation of the peroxisome proliferator activated receptor γ counteracts sepsis-induced T-cell cytotoxicity towards alloantigenic target cells
Knethen, A. von; Sha, L.K.; Knape, T.; Kuchler, L.; Giegerich, A.K.; Schulz, M.; Hauser, I.A.; Brüne, B.
Abstract
2014Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression
Giegerich, A.K.; Kuchler, L.; Sha, L.K.; Knape, T.; Heide, H.; Wittig, I.; Behrends, C.; Brüne, B.; Knethen, A. von
Journal Article
2014Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses
Namgaladze, D.; Lips, S.; Leiker, T.J.; Murphy, R.C.; Ekroos, K.; Ferreiros, N.; Geisslinger, G.; Brüne, B.
Journal Article
2014Lipoxin A4: Problems with its determination using reversed phase chromatography-tandem mass spectrometry and confirmation with chiral chromatography
Ferreiros, N.; Homann, J.; Labocha, S.; Grossmann, N.; Hahn, J.S.; Brüne, B.; Geisslinger, G.
Journal Article
2014Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity
Kallenborn-Gerhardt, W.; Hohmann, S.W.; Syhr, K.M.J.; Schröder, K.; Sisignano, M.; Weigert, A.; Lorenz, J.E.; Lu, R.R.; Brüne, B.; Brandes, R.P.; Geisslinger, G.; Schmidtko, A.
Journal Article
2014PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis
Schiffmann, S.; Weigert, A.; Männich, J.; Eberle, M.; Birod, K.; Häussler, A.; Ferreiros, N.; Schreiber, Y.; Kunkel, H.; Grez, M.; Weichand, B.; Brüne, B.; Pfeilschifter, W.; Nüsing, R.; Niederberger, E.; Grösch, S.; Scholich, K.; Geisslinger, G.
Journal Article
2014Prostacyclin mediates neuropathic pain through interleukin 1β‐expressing resident macrophages
Schuh, C.D.; Pierre, S.; Weigert, A.; Weichand, B.; Altenrath, K.; Schreiber, Y.; Ferreirós, N.; Zhang, D.D.; Suo, J.; Treutlein, E.M.; Henke, M.; Kunkel, H.; Grez, M.; Nüsing, R.; Brüne, B.; Geisslinger, G.; Scholich, K.
Journal Article
2014Sphingosine-1 phosphate promotes thymic atrophy during sepsis progression
Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Knape, T.; Weigert, A.; Brüne, B.; Knethen, A. von
Abstract
2014SYNCRIP-dependent Nox2 mRNA destabilization impairs ROS formation in M2-polarized macrophages
Kuchler, L.; Giegerich, A.K.; Sha, L.K.; Knape, T.; Wong, M.S.K.; Schröder, K.; Brandes, R.P.; Heide, H.; Wittig, I.; Brüne, B.; Knethen, A. von
Journal Article