Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Ready-to-Use Stocks of Agrobacterium tumefaciens can Simplify Process Development for the Production of Recombinant Proteins by Transient Expression in Plants
Spiegel, H.; Boes, A.; Perales Morales, C.; Rademacher, T.; Buyel, J.F.
Journal Article
2018Downstream processing of a plant-derived malaria transmission-blocking vaccine candidate
Menzel, S.; Holland, T.; Boes, A.; Spiegel, H.; Fischer, R.; Buyel, J.F.
Journal Article
2017Herausforderungen an der Schnittstelle von Informatik und Gesellschaft: Institutionalisierte Erforschung der Digitalisierung zur Sicherung von Wohlstand und Fortschritt
Anding, M.; Boes, A.; Eckert, C.; Harhoff, D.; Hess, T.; Münch, U.; Pretschner, A.
Journal Article
2017Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candiate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRpm2 Does Not Improve the In Vitro Efficacy
Spiegel, H.; Boes, A.; Fendel, R.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2017Improvement of a fermentation process for the production of two PfAMA1-DiCo-based malaria vaccine candidates in Pichia pastoris
Kastilan, R.; Boes, A.; Spiegel, H.; Voepel, N.; Chudobova, I.; Hellwig, S.; Buyel, J.F.; Reimann, A.; Fischer, R.
Journal Article
2016Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail
Boes, A.; Spiegel, H.; Kastilan, R.; Bethke, S.; Voepel, N.; Chudobova, I.; Bolscher, J.M.; Dechering, K.J.; Fendel, R.; Buyel, J.F.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2016Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant-derived malaria vaccine candidates
Menzel, S.; Holland, T.; Boes, A.; Spiegel, H.; Bolzenius, J.; Fischer, R.; Buyel, J.F.
Journal Article
2016A Plant-Based Transient Expression System for the Rapid Production of Malaria Vaccine Candidates
Boes, A.; Reimann, A.; Twyman, R.M.; Fischer, R.; Schillberg, S.; Spiegel, H.
Book Article
2015Analysis of a multi-component multi-stage malaria vaccine candidate-tackling the cocktail challenge
Boes, A.; Spiegel, H.; Voepel, N.; Edgue, G.; Beiss, V.; Kapelski, S.; Fendel, R.; Scheuermayer, M.; Pradel, G.; Bolscher, J.M.; Behet, M.C.; Dechering, K.J.; Hermsen, C.C.; Sauerwein, R.W.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Application of a scalable plant transient gene expression platform for malaria vaccine development
Spiegel, H.; Boes, A.; Voepel, N.; Beiss, V.; Edgue, G.; Rademacher, T.; Sack, M.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits
Boes, A.; Spiegel, H.; Edgue, G.; Kapelski, S.; Scheuermayer, M.; Fendel, R.; Remarque, E.; Altmann, F.; Maresch, D.; Reimann, A.; Pradel, G.; Schillberg, S.; Fischer, R.
Journal Article
2015Fast track antibody V-gene rescue, recombinant expression in plants and characterization of a PfMSP4-specific antibody
Kapelski, S.; Boes, A.; Spiegel, H.; Almeida, M. de; Klockenbring, T.; Reimann, A.; Fischer, R.; Barth, S.; Fendel, R.
Journal Article
2015From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants
Sack, M.; Rademacher, T.; Spiegel, H.; Boes, A.; Hellwig, S.; Drossard, J.; Stoger, E.; Fischer, R.
Journal Article
2015Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein
Beiss, V.; Spiegel, H.; Boes, A.; Kapelski, S.; Scheuermayer, M.; Edgue, G.; Sack, M.; Fendel, R.; Reimann, A.; Schillberg, S.; Pradel, G.; Fischer, R.
Journal Article
2015Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10
Maskus, DJ.; Bethke, S.; Seidel, M.; Kapelski, S.; Addai-Mensah, O.; Boes, A.; Edgu, G.; Spiegel, H.; Reimann, A.; Fischer, R.; Barth, S.; Klockenbring, T.; Fendel, R.
Journal Article
2015Optimization of a multi-stage, multi-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites
Spiegel, H.; Schinkel, H.; Kastilan, R.; Dahm, P.; Boes, A.; Scheuermayer, M.; Chudobova, I.; Maskus, D.; Fendel, R.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Plant expression and characterization of the transmission-blocking vaccine candidate PfGAP50
Beiss, V.; Spiegel, H.; Boes, A.; Scheuermayer, M.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2015The stage-specific in vitro efficacy of a malaria antigen cocktail provides valuable insights into the development of effective multi-stage vaccines
Spiegel, H.; Boes, A.; Kastilan, R.; Kapelski, S.; Edgue, G.; Beiss, V.; Chubodova, I.; Scheuermayer, M.; Pradel, G.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2014Malaria vaccine candidate antigen targeting the pre-erythrocytic stage of Plasmodium falciparum produced at high level in plants
Voepel, N.; Boes, A.; Edgue, G.; Beiss, V.; Kapelski, S.; Reimann, A.; Schillberg, S.; Pradel, G.; Fendel, R.; Scheuermayer, M.; Spiegel, H.; Fischer, R.
Journal Article
2014Novel vaccines against apicomplexan pathoges
Boes, Alexander; Edgü, Güven; Beiß, Véronique; Sack, Markus; Reimann, Andreas; Fischer, Rainer
Patent
2014Rational design of a host cell protein heat precipitation step simplifies the subsequent purification of recombinant proteins from tobacco
Buyel, J.F.; Gruchow, H.M.; Boes, A.; Fischer, R.
Journal Article
2012Monoclonal tobacco cell lines with enhanced recombinant protein yields can be generated from heterogeneous cell suspension cultures by flow sorting
Kirchhoff, Janina; Raven, Nicole; Boes, Alexander; Roberts, Jean L.; Russell, Sean; Treffenfeldt, Wiltrud; Fischer, Rainer; Schinkel, Helga; Schiermeyer, Andreas; Schillberg, Stefan
Journal Article
2011Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco
Boes, A.; Spiegel, H.; Delbrück, H.; Fischer, R.; Schillberg, S.; Sack, M.
Journal Article