Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Analyses of association of psoriatic arthritis and psoriasis vulgaris with functional NCF1 variants
Löhr, S.; Ekici, A.B.; Uebe, S.; Büttner, C.; Köhm, M.; Behrens, F.; Böhm, B.; Sticherling, M.; Schett, G.; Simon, D.; Mössner, R.; Nimeh, A.; Oji, V.; Assmann, G.; Rech, J.; Holmdahl, R.; Burkhardt, H.; Reis, A.; Hüffmeier, U.
Journal Article
2019Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab
Mojtahed Poor, S.; Ulshöfer, T.; Gabriel, L.A.; Henke, M.; Köhm, M.; Behrens, F.; Geisslinger, G.; Parnham, M.J.; Burkhardt, H.; Schiffmann, S.
Journal Article
2018Efficacy and safety of tregalizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate
Vollenhoven, R.F. van; Keystone, E.C.; Strand, V.; Pacheco-Tena, C.; Vencovský, J.; Behrens, F.; Racewicz, A.; Zipp, D.; Rharbaoui, F.; Wolter, R.; Knierim, L.; Schmeidl, R.; Zhou, X.; Aigner, S.; Dälken, B.; Wartenberg-Demand, A.
Journal Article
2018Ixekizumab is efficacious when used alone or when added to conventional synthetic disease-modifying antirheumatic drugs (cDMARDs) in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor inhibitors
Nash, P.; Behrens, F.; Orbai, A.-M.; Rathmann, S.S.; Adams, D.H.; Benichou, O.; Deodhar, A.
Journal Article
2018S2e-Leitlinie: Therapie der rheumatoiden Arthritis mit krankheitsmodifizierenden Medikamenten
Fiehn, C.; Holle, J.; Iking-Konert, C.; Leipe, J.; Weseloh, C.; Frerix, M.; Alten, R.; Behrens, F.; Baerwald, C.; Braun, J.; Burkhardt, H.; Burmester, G.; Detert, J.; Gaubitz, M.; Gause, A.; Gromnica-Ihle, E.; Kellner, H.; Krause, A.; Kuipers, J.; Lorenz, H.-M.; Müller-Ladner, U.; Nothacker, M.; Nüsslein, H.; Rubbert-Roth, A.; Schneider, M.; Schulze-Koops, H.; Seitz, S.; Sitter, H.; Specker, C.; Tony, H.-P.; Wassenberg, S.; Wollenhaupt, J.; Krüger, K.
Journal Article
2018Sicherheit und Wirksamkeitshinweise zum Off-label-Einsatz von Biologikatherapien nach Versagen konventioneller Therapien bei Patienten mit entzündlich rheumatischen Erkrankungen
Proft, F.; Schulze-Koops, H.; Grunke, M.; Schrezenmeier, E.; Halleck, F.; Henes, J.; Unger, L.; Schmidt, E.; Fiehn, C.; Jacobi, A.; Iking-Konert, C.; Kneitz, C.; Schmidt, R.E.; Bannert, B.; Voll, R.E.; Fischer-Betz, R.; Kötter, I.; Tony, H.P.; Holle, J.; Aringer, M.; Erler, A.; Behrens, F.; Burmester, G.R.; Dörner, T.
Journal Article
2018Simultaneous response in several domains in patients with psoriatic disease treated with etanercept as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs
Behrens, F.; Meier, L.; Prinz, J.C.; Jobst, J.; Lippe, R.; Löschmann, P.-A.; Lorenz, H.-M.
Journal Article
2018Stellenwert der Kombination von Biologika mit Methotrexat in der Behandlung der Psoriasisarthritis - Fragen bleiben offen
Dauth, S.; Köhm, M.; Rossmanith, T.; Herrmann, E.; Lehn, A.; Burkhardt, H.; Behrens, F.
Journal Article
2017Comparative Analysis of Achievement of Individual Important Response Measured By DAS28dcrit in a Randomized Head-to-Head Trial of Tocilizumab Vs. Adalimumab in Active Rheumatoid Arthritis
Koehm, M.; Hofmann, M.; Lüthje, R.; McIntosh, M.; Abraham, V.; Gabay, C.; Kavanaugh, A.; Burkhardt, H.; Behrens, F.
Abstract
2017Detection of Clinical Signs of Arthritis and Subclinical Evidence of Inflammation in Psoriasis Patients with Risk for Arthritis: Value of Clinical Examination, Ultrasound and Fluorescence-Optical Imaging - Results from the Prospective Multicentre Xciting Study
Koehm, M.; Rossmanith, T.; Langer, H.E.; Backhaus, M.; Burmester, G.R.; Wassenberg, S.; Köhler, B.; Burkhardt, H.; Behrens, F.
Abstract
2017Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients
Uebe, S.; Ehrlicher, M.; Ekici, A.B.; Behrens, F.; Böhm, B.; Homuth, G.; Schurmann, C.; Völker, U.; Jünger, M.; Nauck, M.; Völzke, H.; Traupe, H.; Krawczak, M.; Burkhardt, H.; Reis, A.; Hüffmeier, U.
Journal Article
2017Impact of rituximab in combination with leflunomide and rituximab retreatment with two different dosages on patient-reported outcomes: results from a multicenter randomized placebo controlled investigator initiated clinical trial in active rheumatoid arthritis (AMARA-STUDY)
Köhm, M.; Rossmanith, T.; Dauth, S.; Alten, R.; Aringer, M.; Backhaus, M.; Burmester, G.; Feist, E.; Kellner, H.; Krüger, K.; Müller-Ladner, U.; Rubbert-Roth, A.; Tony, H.P.; Wassenberg, S.; Burkhardt, H.; Behrens, F.
Abstract
2017OP0202 Efficacy and safety of tofacitinib, an oral janus kinase inhibitor, in patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors
Gladman, D.D.; Rigby, W.F.C.; Azevedo, V.F.; Behrens, F.; Blanco, R.; Kaszuba, A.; Kudlacz, E.; Wang, C.; Menon, S.; Hendrikx, T.; Kanik, K.S.
Abstract
2017Psoriasisarthritis Übersicht medikamentöser Therapieoptionen und Anwendungsbesonderheiten
Behrens, F.; Thaci, D.; Wollenhaupt, J.; Krüger, K.
Journal Article
2017Psoriasisarthritis. Aktuelle therapeutische Standards
Köhm, M.; Behrens, F.
Journal Article
2017Tofacitinib for psoriatic arthritis in patients with an inadequate response to TNF inhibitors
Gladman, D.; Rigby, W.; Azevedo, V.F.; Behrens, F.; Blanco, R.; Kaszuba, A.; Kudlacz, E.; Wang, C.; Menon, S.; Hendrikx, T.; Kanik, K.S.
Journal Article
2017Ustekinumab for the treatment of psoriatic arthritis – results of the first interim analysis of the non-interventional study sustain
Wendler, J.; Schwarze, I.; Schwenke, H.; Behrens, J.; Gruppe, T.; Behrens, F.
Abstract
2016Achievement of individual important response measured by Das28dcrit in active rheumatoid arthritis when treated with tocilizumab
Behrens, F.; Köhm, M.; Hofmann, M.; Fliedner, G.; Specker, C.; Burkhardt, H.
Abstract
2016Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis
Behrens, F.; Koehm, M.; Thaci, D.; Gnann, H.; Greger, G.; Wittig, B.M.; Burkhardt, H.
Journal Article
2016Association analysis of psoriasis vulgaris and psoriatic arthritis with loss-of-function mutations in IL36RN in German patients
Löhr, S.; Uebe, S.; Behrens, F.; Böhm, B.; Köhm, M.; Traupe, H.; Oji, V.; Burkhardt, H.; Reis, A.; Hüffmeier, U.
Journal Article
2016Association of Improvement in Pain with Therapeutic Response as Determined by Individual Improvement Criteria in Patients with Rheumatoid Arthritis
Scharbatke, E.C.; Behrens, F.; Schmalzing, M.; Koehm, M.; Greger, G.; Gnann, H.; Burkhardt, H.; Tony, H.-P.
Journal Article
2016Characterization of Ra patients with a DAS28 response to adalimumab therapy by improvement in pain: A german nonintervention study
Köhm, M.; Scharbatke, E.; Stemmler, E.; Greger, G.; Behrens, F.; Wittig, B.
Abstract
2016Comparison of etanercept monotherapy and combination therapy with methotrexate in psoriatic arthritis: Results from 2 clinical trials
Combe, B.; Behrens, F.; McHugh, N.; Brock, F.; Kerkmann, U.; Kola, B.; Gallo, G.
Journal Article
2016Detection of psoriatic arthritis in patients with psoriasis in daily routine care using questionnaires for diagnosis of psoriatic arthritis and fluorescence-optical imaging technique
Köhm, M.; Rossmanith, T.; Langer, H.E.; Burmester, G.; Wassenberg, S.; Kaesser, U.; Backhaus, M.; Burkhardt, H.; Behrens, F.
Abstract
2016Does concomitant methotrexate with adalimumab influence treatment outcomes in patients with psoriatic arthritis? Data from a large observational study
Behrens, F.; Koehm, M.; Arndt, U.; Wittig, B.M.; Greger, G.; Thaci, D.; Scharbatke, E.; Tony, H.-P.; Burkhardt, H.
Journal Article
2016Monotherapy with biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis
Choy, E.; Aletaha, D.; Behrens, F.; Finckh, A.; Gomez-Reino, J.; Gottenberg, J.E.; Schuch, F.; Rubbert-Roth, A.
Journal Article
2016Psoriasisarthritis: Übersicht medikamentöser Therapieoptionen und Anwendungsbesonderheiten
Behrens, F.; Thaci, D.; Wollenhaupt, J.; Krüger, K.
Journal Article
2016Psoriatic arthritis
Koehm, M.; Behrens, F.
Book Article
2016Replication of a distinct psoriatic arthritis risk variant at IL23R
Budu-Aggrey, A.; Bowes, J.; Lohr, S.; Uebe, S.; Zervou, M.I.; Helliwell, P.; Ryan, A.W.; Kane, D.; Korendowych, E.; Giardina, E.; Packham, J.; McManus, R.; FitzGerald, O.; McHugh, N.; Behrens, F.; Burkhardt, H.; Huffmeier, U.; Ho, P.; Martin, J.; Castaneda, S.; Goulielmos, G.; Reis, A.; Barton, A.
Abstract
2016Replication of a distinct psoriatic arthritis risk variant at the IL23R locus
Budu-Aggrey, A.; Bowes, J.; Loehr, S.; Uebe, S.; Zervou, M.I.; Helliwell, P.; Ryan, A.W.; Kane, D.; Korendowych, E.; Giardina, E.; Packham, J.; McManus, R.; Fitzgerald, O.; McHugh, N.; Behrens, F.; Burkhardt, H.; Huffmeier, U.; Ho, P.; Martin, J.; Castaneda, S.; Goulielmos, G.; Reis, A.; Barton, A.
Journal Article
2016Rituximab in combination with leflunomide: Results from a multicenter randomized placebo controlled investigator initiated clinical trial in active rheumatoid arthritis (Amara-Study)
Behrens, F.; Rossmanith, T.; Köhm, M.; Alten, R.; Aringer, M.; Backhaus, M.; Baerwald, C.; Burmester, G.; Feist, E.; Kellner, H.; Krüger, K.; Müller-Ladner, U.; Rubbert-Roth, A.; Tony, H.P.; Wassenberg, S.; Burkhardt, H.
Abstract
2016Severe obesity is frequent in patients with psoriatic arthritis and is accompanied by increased cardiovascular risk
Huscher, D.; Albrecht, K.; Bischoff, S.; Thiele, K.; Behrens, F.; Hoese, G.; Ochs, W.; Zink, A.
Abstract
2016Validation of a distinct psoriatic arthritis risk variant at IL23R
Budu-Aggrey, A.; Bowes, J.; Loehr, S.; Uebe, S.; Zervou, M.I.; Helliwell, P.; Ryan, A.W.; Kane, D.; Korendowych, E.; Giardina, E.; Packham, J.; McManus, R.; FitzGerald, O.; McHugh, N.; Behrens, F.; Burkhardt, H.; Huffmeier, U.; Ho, P.; Martin, J.; Castaneda, S.; Goulielmos, G.; Reis, A.; Barton, A.
Abstract
2015 Association between Skin and Joint Involvement in Patients with Psoriatic Arthritis Treated with Adalimumab: Analysis of Data from a German Non-Interventional Study
Thaci, D.; Behrens, F.; Greger, G.; Burkhardt, H.; Gnann, H.; Schopf, R.; Wittig, B.M.
Journal Article
2015Anti-TNF-α therapy as an evidence-based treatment option for different clinical manifestations of psoriatic arthritis
Köhm, M.; Burkhardt, H.; Behrens, F.
Journal Article
2015Brauchen wir noch klinische Studien in der Rheumatologie?
Henkemeier, U.; Alten, R.; Bannert, B.; Baraliakos, X.; Behrens, F.; Heldmann, F.; Kiltz, U.; Köhm, M.; König, R.; Leipe, J.; Müller-Ladner, U.; Rech, J.; Riechers, E.; Rubbert-Roth, A.; Schmidt, R.E.; Schulze-Koops, H.; Specker, C.; Tausche, A.-K.; Wassenberg, S.; Witt, M.; Witte, T.; Zernicke, J.; Burkhardt, H.
Journal Article
2015Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Bowes, J.; Budu-Aggrey, A.; Huffmeier, U.; Uebe, S.; Steel, K.; Hebert, H.L.; Wallace, C.; Massey, J.; Bruce, I.N.; Bluett, J.; Feletar, M.; Morgan, A.W.; Marzo-Ortega, H.; Donohoe, G.; Morris, D.W.; Helliwell, P.; Ryan, A.R.; Kane, D.; Warren, R.B.; Korendowych, E.; Alenius, G.-M.; Giardina, E.; Packham, J.; McManus, R.; FitzGerald, O.; McHugh, N.; Brown, M.A.; Ho, P.; Behrens, F.; Burkhardt, H.; Reis, A.; Barton, A.
Journal Article
2015Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Bowes, J.; Budu-Aggrey, A.; Huffmeier, U.; Uebe, S.; Steel, K.; Hebert, H.L.; Wallace, C.; Massey, J.; Bruce, I.N.; Bluett, J.; Feletar, M.; Morgan, A.W.; Marzo-Ortega, H.; Donohoe, G.; Morris, D.W.; Helliwell, P.; Ryan, A.W.; Kane, D.; Warren, R.B.; Korendowych, E.; Alenius, G.-M.; Giardina, E.; Packham, J.; McManus, R.; Fitzgerald, O.; McHugh, N.; Brown, M.A.; Ho, P.; Behrens, F.; Burkhardt, H.; Reis, A.; Barton, A.
Journal Article
2015MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis
Behrens, F.; Tak, P.P.; Østergaard, M.; Stoilov, R.; Wiland, P.; Huizinga, T.W.; Berenfus, V.Y.; Vladeva, S.; Rech, J.; Rubbert-Roth, A.; Korkosz, M.; Rekalov, D.; Zupanets, I.A.; Ejbjerg, B.J.; Geiseler, J.; Fresenius, J.; Korolkiewicz, R.P.; Schottelius, A.J.; Burkhardt, H.
Journal Article
2015Non-response to Antitnf treatment in psoriatic arthritis can be predicted by an objective automated measurement of fluorescence-signal intensities in fluorescence-optical imaging technique - the first interims analysis of the xplore-study
Koehm, M.; Rossmanith, T.; Henkemeier, U.; Aries, P.; Alten, R.; Langer, H.-E.; Burkhardt, H.; Behrens, F.
Abstract
2015Patients with psoriatic arthritis and oligoarthritic subtype report higher disease burden than patients with a polyarthritic pattern - data from the german collaborative arthritis centres
Huscher, D.; Albrecht, K.; Bischoff, S.; Thiele, K.; Behrens, F.; Fischer, K.; Hinüber, U. von; Späthling-Mestekemper, S.; Wassenberg, S.; Zink, A.
Abstract
2015Pharmakotherapie der Psoriasisarthritis
Köhm, M.; Behrens, F.
Journal Article
2015A phase 2b study evaluating the efficacy and safety of subcutaneously administered tregalizumab in subjects with active Rheumatoid Arthritis (RA) despite treatment with Methotrexate (MTX)
Vollenhoven, R.F. van; Keystone, E.C.; Strand, V.; Pacheco-Tena, C.; Vencovsky, J.; Behrens, F.; Zipp, D.; Rharbaoui, F.; Wolter, R.; Tiemann, R.-D.; Knierim, L.; Schmeidl, R.; Zhou, X.; Aigner, S.; Daelken, B.; Wartenberg-Demand, A.
Abstract
2015Predictors of therapeutic response in ankylosing spondylitis patients initiating therapy with adalimumab in a german non-interventional study
Koehm, M.; Behrens, F.; Scharbatke, E.C.; Schmalzing, M.; Gnann, H.; Greger, G.; Wittig, B.; Tony, H.P.; Burkhardt, H.
Abstract
2015PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: Evidence for a further PsA-specific risk locus
Bowes, J.; Loehr, S.; Budu-Aggrey, A.; Uebe, S.; Bruce, I.N.; Feletar, M.; Marzo-Ortega, H.; Helliwell, P.; Ryan, A.W.; Kane, D.; Korendowych, E.; Alenius, G.-M.; Giardina, E.; Packham, J.; McManus, R.; FitzGerald, O.; Brown, M.A.; Behrens, F.; Burkhardt, H.; McHugh, N.; Huffmeier, U.; Ho, P.; Reis, A.; Barton, A.
Journal Article
2015Validation of a distinct psoriatic arthritis risk variant at IL23R
Budu-Aggrey, A.; Bowes, J.; Lohr, S.; Zervou, M.I.; Helliwell, P.S.; Ryan, A.W.; Kane, D.; Korendowych, E.; Giardina, E.; Packham, J.; McManus, R.; FitzGerald, O.; McHugh, N.J.; Behrens, F.; Burkhardt, H.; Huffmeier, U.; Martin, J.; Goulielmos, G.; Ho, P.; Reis, A.; Barton, A.
Abstract
2014Effects of methotrexate on anti-TNF treatment in rheumatoid arthritis
Schmalzing, M.; Behrens, F.; Scharbatke, E.C.; Koehm, M.; Wittig, B.; Greger, G.; Burkhardt, H.; Tony, H.P.
Abstract
2014Rheumatoid factor status is a predictor of osteoporosis in patients with psoriatic arthritis
Behrens, F.; Koehm, M.; Scharbatke, E.C.; Wittig, B.; Schmalzing, M.; Gnann, H.; Lorenz, H.M.; Thaci, D.; Burkhardt, H.
Abstract
2014SAT0358 impact of methotrexate on anti-TNF treatment in psoriatic arthritis? An in-depth analysis of a large prospective observational study with adalimumab
Behrens, F.; Köhm, M.; Arndt, U.; Wittig, B.; Greger, G.; Thaci, D.; Scharbatke, E.; Tony, H.P.; Burkhardt, H.
Abstract
2014Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA
Behrens, F.; Cañete, J.D.; Olivieri, I.; Kuijk, A.W. van; McHugh, N.; Combe, B.
Journal Article
2014Validity of additional use of optical immunofluorescence imaging technique (Xiralite®) in detection of active psoriatic arthritis and measurement of disease activity in patients with psoriasis and psoriatic arthritis
Köhm, M.; Roßmanith, T.; Burkhardt, H.; Behrens, F.
Abstract
2013Development and validation of a new disease activity score in 28 joints–based treatment response criterion for rheumatoid arthritis
Behrens, F.; Tony, H.-P.; Alten, R.; Kleinert, S.; Scharbatke, E.C.; Köhm, M.; Gnann, H.; Tams, J.; Greger, G.; Burkhardt, H.
Journal Article
2013DMARD-Versager vs. TNF-Versager bei aktiver Psoriasis-Arthritis: Vergleichende Untersuchung zu Krankheitscharakteristika aus einer großen prospektiven Observationsstudie vor Einleitung einer Therapie mit Adalimumab
Behrens, F.; Köhm, M.; Thaci, D.; Krummel-Lorenz, B.; Greger, G.; Wittig, B.; Burkhardt, H.
Abstract
2013Gibt es eine Assoziation zwischen Haut- und Gelenkmanifestation bei Patienten mit Psoriasis-Arthritis? – Datenanalyse einer deutschen nichtinterventionellen Studie mit Adalimumab bei aktiver Psoriasis-Arthritis
Köhm, M.; Behrens, F.; Thaci, D.; Krummel-Lorenz, B.; Greger, G.; Wittig, B.; Burkhardt, H.
Abstract
2013Leflunomide in psoriatic arthritis: Results from a large European prospective observational study
Behrens, F.; Finkenwirth, C.; Pavelka, K.; S̆tolfa, J.; S̆ipek-Dolnicar, A.; Thaçi, D.; Burkhardt, H.
Journal Article
2013Personalisierte Medizin bei Zytokin-gerichteten Therapien
Behrens, F.; Köhm, M.
Journal Article
2013Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics
Mease, P.; Gladman, D.; Papp, K.; Khraishi, M.; Thaci, D.; Behrens, F.; Northington, R.; Fuiman, J.; Bananis, E.; Boggs, R.; Alvarez, D.
Journal Article
2013Variants in RUNX3 contribute to susceptibility to psoriatic arthritis, exhibiting further common ground with ankylosing spondylitis
Apel, M.; Uebe, S.; Bowes, J.; Giardina, E.; Korendowych, E.; Juneblad, K.; Pasutto, F.; Ekici, A.B.; McManus, R.; Ho, P.; Bruce, I.N.; Ryan, A.W.; Behrens, F.; Böhm, B.; Traupe, H.; Lohmann, J.; Gieger, C.; Wichmann, H.-E.; Padyukov, L.; FitzGerald, O.; Alenius, G.-M.; McHugh, N.J.; Novelli, G.; Burkhardt, H.; Barton, A.; Reis, A.; Hüffmeier, U.
Journal Article
2013Wirksamkeit von Adalimumab bei aktiver Psoriasis-Arthritis und unzureichendem Ansprechen auf bis zu drei Anti-TNF-Vortherapien
Köhm, M.; Behrens, F.; Thaci, D.; Krummel-Lorenz, B.; Greger, G.; Wittig, B.; Burkhardt, H.
Abstract