Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands
Renner, Andreas; Romanova, Julia; Ferko, Boris; Schmutz, Helmut; Nebolsin, Vladimir; Müller, Meike; Badorrek, Philipp; Marth, Katharina; Pohl, Wolfgang
Journal Article
2018A computational framework for complex disease stratification from multiple large-scale datasets
Meulder, Bertrand de; Lefaudeux, Diane; Bansal, Aruna T.; Mazein, Alexander; Chaiboonchoe, Amphun; Ahmed, Hassan; Balaur, Irina; Saqi, Mansoor; Pellet, Johann; Ballereau, Stephane; Lemonnier, Nathanaël; Sun, Kai; Pandis, Ioannis; Yang, Xian; Batuwitage, Manohara; Kretsos, Kosmas; Eyll, Jonathan van; Bedding, Alun; Davison, Timothy; Dodson, Paul; Larminie, Christopher; Postle, Anthony; Corfield, Julie; Djukanović, Ratko; Chung, Kian Fan; Adcock, Ian M.; Guo, Yi-Ke; Sterk, Peter J.; Manta, Alexander; Rowe, Anthony; Baribaud, Frédéric; Auffray, Charles; Badorrek, Philipp; Faulenbach, Cornelia; Braun, Armin; Hohlfeld, Jens; Krug, Norbert
Journal Article
2018Phase 1 pharmacokinetics and phase 3 efficacy of testosterone nasal gel in subjects with seasonal allergies
Rogol, Alan D.; Tkachenko, Natalia; Badorrek, Philipp; Hohlfeld, Jens M.; Bryson, Nathan
Journal Article
2017Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure
Badorrek, Philipp; Müller, Meike; Koch, Wolfgang; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2016Prevalence of ragweed sensitization at a clinical trial unit in northern Germany
Badorrek, P.; Krug, N.; Hohlfeld, J.M.
Abstract
2016Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber
Lüer, Katrin; Biller, Heike; Casper, Anja; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, A.; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Journal Article
2016Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
Loza, M.J.; Djukanovic, R.; Chung, K.F.; Horowitz, D.; Ma, K.; Branigan, P.; Barnathan, E.S.; Susulic, V.S.; Silkoff, P.E.; Sterk, P.J.; Baribaud, F.; Badorrek, P.; Faulenbach, C.; Braun, A.; Hohlfeld, J.; Krug, N.; et. al.
Journal Article
2015Controlled exposure to grass pollen in an environmental challenge chamber induces a worsening of cutaneous symptoms in patients with atopic dermatitis
Heratizadeh, A.; Badorrek, P.; Kapp, A.; Niebuhr, M.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Loesche, C.; Jung, T.; Krug, N.; Hohlfeld, J.M.; Werfel, T.
Abstract
2015Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis
Badorrek, Philipp; Hohlfeld, Jens M.; Krug, Norbert; Joshi, Abhijeet; Raut, Atul
Journal Article
2015Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
Werfel, T.; Heratizadeh, A.; Niebuhr, M.; Kapp, A.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Lösche, C.; Jung, T.; Krug, N.; Badorrek, P.; Hohlfeld, J.M.
Journal Article
2015A novel universal allergen challenge technique for efficacy testing of immunotherapy
Schwarz, K.; Lueer, K.; Biller, H.; Windt, H.; Badorrek, P.; Hafner, D.; Koch, A.; Krug, N.; Koch, W.; Hohlfeld, J.
Abstract
2014Dose-range finding of natural birch pollen exposure in patients with seasonal allergic rhinitis in the Fraunhofer Environmental Challenge Chamber
Lüer, Katrin; Windt, Horst; Schwarz, Katharina; Badorrek, Philipp; Sebastian, Ramona; Haefner, Dietrich; Koch, Wolfgang; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014The effect of controlled exposure to grass pollen in an environmental challenge chamber on dermal symptoms in patients with atopic dermatitis
Heratizadeh, Annice; Badorrek, Philipp; Niebuhr, Margarete; Erpenbeck, Veit Johannes; Lösche, C.; Krug, Norbert; Hohlfeld, Jens Michael; Werfel, Thomas
Abstract
2014Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis
Krug, Norbert; Gupta, Abhy; Badorrek, Philipp; Koennen, Ruediger; Mueller, Meike; Pivovarova, Anna; Hilbert, James; Wetzel, Kristiane; Hohlfeld, Jens M.; Wood, Chester
Journal Article
2012CRTH2 antagonist, BI 671800 (BI), reduces nasal symptoms and inhibits nasal cytokines and eosinophils in SAR patients exposed to grass pollen in an environmental challenge chamber (ECC)
Krug, Norbert; Gupta, A.; Badorrek, Philipp; Müller, Meike; Casper, Anja; Pivovarova, A.; Hilbert, J.; Koenen, R.; Hohlfeld, Jens M.; Wood, C.
Abstract
2012Experience with an allergen challenge chamber for clinical trials in allergic rhinitis
Krug, Norbert; Badorrek, Phillipp; Hohlfeld, Jens Michael
Journal Article, Conference Paper
2012Pollen starch granules in bronchial inflammation
Badorrek, Philipp; Dick, Melanie; Emmert, Lorenz; Schaumann, Frank; Koch, Wolfgang; Hecker, Hartmut; Murdoch, Robert; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2012Safety and efficacy of house dust mite allergen challenge in patients with allergic rhinitis using a novel technique for inhalation studies in the Fraunhofer environmental challenge chamber
Lueer, Katrin; Biller, Heike; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, Armin; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Abstract
2011Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Schaumann, F.; Hohlfeld, J.M.; Krug, N.; Sousa, A.R.; Murdoch, R.
Journal Article
2009A combination of cetirizine and pseudoephedrine has therapeutic benefits when compared to single drug treatment in allergic rhinitis
Badorrek, P.; Dick, M.; Schauerte, A.; Hecker, H.; Murdoch, R.; Luettig, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2009Efficacy of a rush immunotherapy with a depigmented polymerised extract of grass pollen assessed in an environmental challenge chamber
Biller, H.; Badorrek, P.; Hohlfeld, J.; Krug, N.; Sager, A.
Abstract
2008Efficacy of a rush immunotherapy with a depigmented polymerized extract of grass pollen using an enviromental challenge chamber (ECC)
Sager, A.; Braeutigam, M.; Badorrek, P.; Krug, N.
Abstract
2008The role of pollen starch granules in bronchial inflammation
Badorrek, P.; Larbig, M.; Dick, M.; Koch, W.; Hecker, H.; Hohlfeld, J.; Krug, N.
Abstract
2008Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis following pollen exposure in the Fraunhofer Environmental Challenge Chamber (ECC)
Badorrek, P.; Dick, M.; Hoffmann, M.; Hecker, H.; Hohlfeld, J.; Krug, N.
Abstract
2008The therapeutic effect of a combination of cetirizine and pseudoephedrine compared to placebo is equivalent when tested in an environmental challenge chamber both within and out of the grass pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Murdoch, R.; Sousa, A.; Hohlfeld, J.; Krug, N.
Abstract
2007The combination therapy with cetirizine and pseudoephedrine is more effective than the treatment with single substances in patients with allergic rhinitis
Badorrek, P.; Bennack, M.; Buckow, K.; Schauerte, A.; Hoffmann, M.; Hecker, H.; Murdoch, R.; Hohlfeld, J.; Krug, N.
Conference Paper, Journal Article
2005Pulmonale Sicherheitsaspekte bei Patienten mit allergischer Rhinitis während Gräserpollenprovokation in einem kontrollierten Expositionsraum
Badorrek, P.
: Krug, N. (Prüfer)
Dissertation
2003Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis
Krug, N.; Loedding, H.; Hohlfeld, J.M.; Larbig, M.; Buckendahl, A.; Badorrek, P.; Geldmacher, H.; Behnke, W.; Dunkhorst, W.; Windt, H.; Luettig, B.; Koch, W.
Journal Article
2002A pilot study to assess the efficacy of loteprednol etabonate nasal spray as a treatment for allergic rhinitis in an environmental exposure unit (eeu)
Geldmacher, H.; Buckendahl, A.; Badorrek, P.; Nguyen, D.; Lavallee, N.; Petzold, U.; Hermann, R.; Hohlfeld, J.M.; Krug, N.
Journal Article