Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Computer-Aided Selective Optimization of Side Activities of Talinolol
Hiesinger, K.; Kramer, J.S.; Achenbach, J.; Moser, D.; Weber, J.; Wittmann, S.K.; Morisseau, C.; Angioni, C.; Geisslinger, G.; Kahnt, A.S.; Kaiser, A.; Proschak, A.; Steinhilber, D.; Pogoryelov, D.; Wagner, K.; Hammock, B.D.; Proschak, E.
Journal Article
2019Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
Schwarzkopf, K.M.; Queck, A.; Thomas, D.; Angioni, C.; Cai, C.; Freygang, Y.; Rüschenbaum, S.; Geisslinger, G.; Zeuzem, S.; Welsch, C.; Lange, C.M.
Journal Article
2019Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ
Göbel, T.; Diehl, O.; Heering, J.; Merk, D.; Angioni, C.; Wittmann, S.K.; Buscato, E. la; Kottke, R.; Weizel, L.; Schader, T.; Maier, T.J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Steinhilber, D.; Proschak, E.; Kahnt, A.S.
Journal Article
2018Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
Ringleb, J.; Strack, E.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Weigert, A.; Brüne, B.
Journal Article
2018Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase
Roos, J.; Peters, M.; Maucher, I.V.; Kühn, B.; Fettel, J.; Hellmuth, N.; Brat, C.; Sommer, B.; Urbschat, A.; Piesche, M.; Vogel, A.; Proschak, E.; Blöcher, R.; Buscató, E.; Häfner, A.-K.; Matrone, C.; Werz, O.; Heidler, J.; Wittig, I.; Angioni, C.; Geisslinger, G.; Parnham, M.J.; Zacharowski, K.; Steinhilber, D.; Maier, T.J.
Journal Article
2018Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains
Bruin, N. de; Ferreirós, N.; Schmidt, M.; Hofmann, M.; Angioni, C.; Geisslinger, G.; Parnham, M.J.
Journal Article
2018The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain
Zimmer, B.; Angioni, C.; Osthues, T.; Toewe, A.; Thomas, D.; Pierre, S.C.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
2017CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages
Kern, K.; Pierre, S.; Schreiber, Y.; Angioni, C.; Thomas, D.; Ferreirós, N.; Geisslinger, G.; Scholich, K.
Journal Article
2017Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles
Kretschmer, S.B.M.; Woltersdorf, S.; Vogt, D.; Lillich, F.F.; Rühl, M.; Karas, M.; Maucher, I.V.; Roos, J.; Häfner, A.-K.; Kaiser, A.; Wurglics, M.; Schubert-Zsilavecz, M.; Angioni, C.; Geisslinger, G.; Stark, H.; Steinhilber, D.; Hofmann, B.
Journal Article
2017Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase
Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Blöcher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fürst, R.; Proschak, E.
Journal Article
2017The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers
Janas, C.; Mast, M.P.; Kirsamer, L.; Angioni, C.; Gao, F.; Mäntele, W.; Dressman, J.; Wacker, M.G.
Journal Article
2017A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter nonalcoholic steatohepatitis
Schmidt, J.; Rotter, M.; Weiser, T.; Wittmann, S.; Weizel, L.; Kaiser, A.; Heering, J.; Goebel, T.; Angioni, C.; Wurglics, M.; Paulke, A.; Geisslinger, G.; Kahnt, A.; Steinhilber, D.; Proschak, E.; Merk, D.
Journal Article
2017Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis
Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Knape, T.; Angioni, C.; Ferreiros, N.; Schmidt, M.V.; Weigert, A.; Brüne, B.; Knethen, A. von
Journal Article
2017The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity
Hohmann, S.W.; Angioni, C.; Tunaru, S.; Lee, S.; Woolf, C.J.; Offermanns, S.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
2017The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons
Zinn, S.; Sisignano, M.; Kern, K.; Pierre, S.; Tunaru, S.; Jordan, H.; Suo, J.; Treutlein, E.M.; Angioni, C.; Ferreiros, N.; Leffler, A.; DeBruin, N.; Offermanns, S.; Geisslinger, G.; Scholich, K.
Journal Article
2017R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4
Wobst, I.; Ebert, L.; Birod, K.; Wegner, M.-S.; Hoffmann, M.; Thomas, D.; Angioni, C.; Parnham, M.J.; Steinhilber, D.; Tegeder, I.; Geisslinger, G.; Grösch, S.
Journal Article
2016Epigenetic Control of Microsomal Prostaglandin E Synthase-1 by HDAC Mediated Recruitment of p300
Fork, C.; Vasconez, A.E.; Janetzko, P.; Angioni, C.; Schreiber, Y.; Ferreiros, N.; Geisslinger, G.; Leisegang, M.S.; Steinhilber, D.; Brandes, R.P.
Journal Article
2016N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators
Blöcher, R.; Lamers, C.; Wittmann, S.K.; Merk, D.; Hartmann, M.; Weizel, L.; Diehl, O.; Brüggerhoff, A.; Boss, M.; Kaiser, A.; Schader, T.; Gobel, T.; Grundmann, M.; Angioni, C.; Heering, J.; Geisslinger, G.; Wurglics, M.; Kostenis, E.; Brüne, B.; Steinhilber, D.; Schubert-Zsilavecz, M.; Kahnt, A.S.; Proschak, E.
Journal Article
2016PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells
Josipovic, I.; Fork, C.; Preussner, J.; Prior, K.-K.; Iloska, D.; Vasconez, A.E.; Labocha, S.; Angioni, C.; Thomas, D.; Ferreirós, N.; Looso, M.; Pullamsetti, S.S.; Geisslinger, G.; Steinhilber, D.; Brandes, R.P.; Leisegang, M.S.
Journal Article
2016Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain
Sisignano, M.; Angioni, C.; Park, C.-K.; Santos, S.M.D.; Jordan, H.; Kuzikov, M.; Liu, D.; Zinn, S.; Hohman, S.W.; Schreiber, Y.; Zimmer, B.; Schmidt, M.; Lu, R.; Suo, J.; Zhang, D.-D.; Schäfer, S.M.G.; Hofmann, M.; Yekkirala, A.S.; De Bruin, N.; Parnham, M.J.; Woolf, C.J.; Ji, R.-R.; Scholich, K.; Geisslinger, G.
Journal Article
2015AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages
Namgaladze, D.; Snodgrass, R.G.; Angioni, C.; Grossmann, N.; Dehne, N.; Geisslinger, G.; Brüne, B.
Journal Article
2015Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein
Lehmann, C.; Homann, J.; Ball, A.-K.; Blöcher, R.; Kleinschmidt, T.K.; Basavarajappa, D.; Angioni, C.; Ferreirós, N.; Häfner, A.-K.; Radmark, O.; Proschak, E.; Haeggström, J.Z.; Geisslinger, G.; Parnham, M.J.; Steinhilber, D.; Kahnt, A.S.
Journal Article
2015MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer
Olesch, C.; Sha, W.; Angioni, C.; Sha, L.K.; Acaf, E.; Patrignani, P.; Jakobsson, P.-J.; Radeke, H.H.; Grösch, S.; Geisslinger, G.; Knethen, A. von; Weigert, A.; Brüne, B.
Journal Article
2014Prostacyclin Regulates Spinal Nociceptive Processing through Cyclic Adenosine Monophosphate–induced Translocation of Glutamate Receptors
Schuh, C.D.; Brenneis, C.; Zhang, D.D.; Angioni, C.; Schreiber, Y.; Ferreiros-Bouzas, N.; Pierre, S.; Henke, M.; Linke, B.; Nüsing, R.; Scholich, K.; Geisslinger, G.
Journal Article
2014Similar Maximum Systemic but not Local Cyclooxygenase-2 Inhibition by 50 mg Lumiracoxib and 90 mg Etoricoxib
Felden, L.; Walter, C.; Angioni, C.; Schreiber, Y.; Hentig, N. von; Ferreiros, N.; Geisslinger, G.; Lötsch, J.
Journal Article
2013Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity
Kahnt, A.S.; Rörsch, F.; Diehl, O.; Hofmann, B.; Lehmann, C.; Steinbrink, S.D.; Angioni, C.; Geisslinger, G.; Grösch, S.; Steinhilber, D.; Maier, T.J.
Journal Article